Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, et al. A guiding map for inflammation. Nat Immunol. 2017;18:826–31.
PubMed
PubMed Central
CAS
Google Scholar
Furman D, Campisi J, Verdin E. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25:1822–32.
PubMed
PubMed Central
CAS
Google Scholar
Kushner I, Samols D, Magrey M. A unifying biologic explanation for “high-sensitivity” C-reactive protein and “low-grade” inflammation. Arthritis care & research. 2010;62:442–6.
CAS
Google Scholar
Leon-Pedroza JI, Gonzalez-Tapia LA, del Olmo-Gil E, Castellanos-Rodriguez D, Escobedo G, Gonzalez-Chavez A. Low-grade systemic inflammation and the development of metabolic diseases: from the molecular evidence to the clinical practice. Cir Cir. 2015;83:543–51.
PubMed
Google Scholar
Calder PC, Bosco N, Bourdet-Sicard R, Capuron L, Delzenne N, Dore J, et al. Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. Ageing Res Rev. 2017;40:95–119.
PubMed
CAS
Google Scholar
Kolb H, Mandrup-Poulsen T. The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation. Diabetologia. 2010;53:10–20.
PubMed
CAS
Google Scholar
Tamakoshi K, Yatsuya H, Kondo T, Hori Y, Ishikawa M, Zhang H, et al. The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state. Int J Obes Relat Metab Disord. 2003;27:443–9.
PubMed
CAS
Google Scholar
Ridker PM. High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation. 2001;103:1813–8.
PubMed
CAS
Google Scholar
Tao Q, Ang TFA, DeCarli C, Auerbach SH, Devine S, Stein TD, et al. Association of Chronic low-grade Inflammation with Risk of Alzheimer disease in ApoE4 carriers. JAMA Netw Open. 2018;1:e183597.
PubMed
PubMed Central
Google Scholar
Lasselin J, Capuron L. Chronic low-grade inflammation in metabolic disorders: relevance for behavioral symptoms. Neuroimmunomodulation. 2014;21:95–101.
PubMed
CAS
Google Scholar
Otani T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S. Group JPHCBPS: plasma C-reactive protein and risk of colorectal cancer in a nested case-control study: Japan public health center–based prospective study. Cancer Epidemiology and Prevention Biomarkers. 2006;15:690–5.
CAS
Google Scholar
Giovannini S, Onder G, Liperoti R, Russo A, Carter C, Capoluongo E, et al. Interleukin-6, C-reactive protein, and tumor necrosis factor-alpha as predictors of mortality in frail, community-living elderly individuals. J Am Geriatr Soc. 2011;59:1679–85.
PubMed
PubMed Central
Google Scholar
Bonaccio M, Di Castelnuovo A, Pounis G, De Curtis A, Costanzo S, Persichillo M, et al. A score of low-grade inflammation and risk of mortality: prospective findings from the Moli-sani study. Haematologica. 2016;101:1434–41.
PubMed
PubMed Central
CAS
Google Scholar
Zhou Z, Xu MJ, Gao B. Hepatocytes: a key cell type for innate immunity. Cell Mol Immunol. 2016;13:301–15.
PubMed
CAS
Google Scholar
Rhodes B, Fürnrohr BG, Vyse TJ. C-reactive protein in rheumatology: biology and genetics. Nat Rev Rheumatol. 2011;7:282–9.
PubMed
CAS
Google Scholar
Devaraj S, Jialal I. C-reactive protein polarizes human macrophages to an M1 phenotype and inhibits transformation to the M2 phenotype. Arterioscler Thromb Vasc Biol. 2011;31:1397–402.
PubMed
PubMed Central
CAS
Google Scholar
Devaraj S, Davis B, Simon SI, Jialal I. CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human aortic endothelial cells under static and shear flow conditions. Am J Physiol Heart Circ Physiol. 2006;291:H1170–6.
PubMed
CAS
Google Scholar
Markiewski MM, Lambris JD. The role of complement in inflammatory diseases from behind the scenes into the spotlight. Am J Pathol. 2007;171:715–27.
PubMed
PubMed Central
CAS
Google Scholar
Davalos D, Akassoglou K. Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol. 2012;34:43–62.
PubMed
CAS
Google Scholar
Nadar SK, Lip GY. New insights into complement C3 and inflammation in hypertension. J Hum Hypertens. 2007;21:261–3.
PubMed
CAS
Google Scholar
Sabour H, Latifi S, Soltani Z, Shakeri H, Norouzi Javidan A, Ghodsi SM, et al. C-reactive protein as an available biomarker determining mental component of health-related quality of life among individuals with spinal cord injury. J Spinal Cord Med. 2017;40:329–37.
PubMed
Google Scholar
Suarez EC. C-reactive protein is associated with psychological risk factors of cardiovascular disease in apparently healthy adults. Psychosom Med. 2004;66:684–91.
PubMed
CAS
Google Scholar
Boyle SH, Jackson WG, Suarez EC. Hostility, anger, and depression predict increases in C3 over a 10-year period. Brain Behav Immun. 2007;21:816–23.
PubMed
PubMed Central
CAS
Google Scholar
Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives–a review. J Tradit Complement Med. 2017;7:205–33.
PubMed
Google Scholar
Aggarwal BB, Yuan W, Li S, Gupta SC. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: identification of novel components of turmeric. Mol Nutr Food Res. 2013;57:1529–42.
PubMed
CAS
Google Scholar
Mehra KS, Mikuni I, Gupta U, Gode KD. Curcuma longa (Linn) drops in corneal wound healing. Tokai J Exp Clin Med. 1984;9:27–31.
PubMed
CAS
Google Scholar
Yu ZF, Kong LD, Chen Y. Antidepressant activity of aqueous extracts of Curcuma longa in mice. J Ethnopharmacol. 2002;83:161–5.
PubMed
CAS
Google Scholar
Li Y, Shi X, Zhang J, Zhang X, Martin RC. Hepatic protection and anticancer activity of curcuma: a potential chemopreventive strategy against hepatocellular carcinoma. Int J Oncol. 2014;44:505–13.
PubMed
CAS
Google Scholar
Anandakumar S, Joseph JA, Bethapudi B, Agarwal A, Jung E-B. Anti-inflammatory effects of turmeric (Curcuma longa L.) extract on acute and chronic inflammation models. Journal of the Korean Society of Food Science and Nutrition. 2014;43:612–7.
CAS
Google Scholar
Sengupta M, Sharma GD, Chakraborty B. Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice. Asian Pac J Trop Biomed. 2011;1:193–9.
PubMed
PubMed Central
CAS
Google Scholar
Uchio R, Murosaki S, Ichikawa H. Hot water extract of turmeric (Curcuma longa) prevents non-alcoholic steatohepatitis in mice by inhibiting hepatic oxidative stress and inflammation. J Nutr Sci. 2018;7:e36.
PubMed
PubMed Central
CAS
Google Scholar
Mun J, Kim S, Yoon HG, You Y, Kim OK, Choi KC. Water extract of Curcuma longa L. Ameliorates Non-Alcoholic Fatty Liver Disease. Nutrients. 2019;11:2536.
PubMed Central
CAS
Google Scholar
Nagavekar N, Singhal RS. Supercritical fluid extraction of Curcuma longa and Curcuma amada oleoresin: optimization of extraction conditions, extract profiling, and comparison of bioactivities. Ind Crop Prod. 2019;134:134–45.
CAS
Google Scholar
Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMC Med. 2010;8:18.
PubMed
PubMed Central
Google Scholar
Shiwaku K, Anuurad E, Enkhmaa B, Nogi A, Kitajima K, Shimono K, et al. Overweight Japanese with body mass indexes of 23.0-24.9 have higher risks for obesity-associated disorders: a comparison of Japanese and Mongolians. Int J Obes Relat Metab Disord. 2004;28:152–8.
PubMed
CAS
Google Scholar
Uchio R, Muroyama K, Okuda-Hanafusa C, Kawasaki K, Yamamoto Y, Murosaki S. Hot Water Extract of Curcuma longa L. Improves Serum Inflammatory Markers and General Health in Subjects with Overweight or Prehypertension/Mild Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2019;11:1822.
PubMed Central
CAS
Google Scholar
Kawasaki K, Muroyama K, Yamamoto N, Murosaki S. A hot water extract of Curcuma longa inhibits adhesion molecule protein expression and monocyte adhesion to TNF-alpha-stimulated human endothelial cells. Biosci Biotechnol Biochem. 2015;79:1654–9.
PubMed
CAS
Google Scholar
Su JY, Tan LR, Lai P, Liang HC, Qin Z, Ye MR, et al. Experimental study on anti-inflammatory activity of a TCM recipe consisting of the supercritical fluid CO2 extract of Chrysanthemum indicum, patchouli oil and zedoary turmeric oil in vivo. J Ethnopharmacol. 2012;141:608–14.
PubMed
CAS
Google Scholar
Fukuhara S, Bito S, Green J, Hsiao A, Kurokawa K. Translation, adaptation, and validation of the SF-36 health survey for use in Japan. J Clin Epidemiol. 1998;51:1037–44.
PubMed
CAS
Google Scholar
Fukuhara S, Ware JE Jr, Kosinski M, Wada S, Gandek B. Psychometric and clinical tests of validity of the Japanese SF-36 health survey. J Clin Epidemiol. 1998;51:1045–53.
PubMed
CAS
Google Scholar
Heuchert JP. McNair DM: profile of mood states, POMS-2. North Tonawanda: Multi-Health Systems Inc; 2012.
Google Scholar
Yokoyama K, Watanabe K. Translation of POMS 2: profile of mode states second edition (in Japanese). Tokyo, Japan: Kaneko Shobo; 2015.
Google Scholar
Bogdanski P, Suliburska J, Szulinska M, Stepien M, Pupek-Musialik D, Jablecka A. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients. Nutr Res. 2012;32:421–7.
PubMed
CAS
Google Scholar
Kucukerdonmez O, Rakıcıoglu N. The effect of seasonal variations on food consumption, dietary habits, anthropometric measurements and serum vitamin levels of university students. Prog Nutr. 2018;20:165–75.
CAS
Google Scholar
Iwao T, Sakai K, Ando E. Seasonal fluctuations of glycated hemoglobin levels in Japanese diabetic patients: effect of diet and physical activity. Diabetol Int. 2013;4:173–8.
Google Scholar
Blüher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019;15:288–98.
Google Scholar
Kim JH, Kim OK, Yoon HG, Park J, You Y, Kim K, et al. Anti-obesity effect of extract from fermented Curcuma longa L through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats. Food Nutr Res. 2016;60:30428.
PubMed
Google Scholar
Song WY, Choi JH. Korean Curcuma longa L. induces lipolysis and regulates leptin in adipocyte cells and rats. Nutr Res Pract. 2016;10:487–93.
PubMed
PubMed Central
CAS
Google Scholar
Yoshizumi T, Nakamura T, Yamane M, Islam AH, Menju M, Yamasaki K, et al. Abdominal fat: standardized technique for measurement at CT. Radiology. 1999;211:283–6.
PubMed
CAS
Google Scholar
Ryo M, Maeda K, Onda T, Katashima M, Okumiya A, Nishida M, et al. A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance. Diabetes Care. 2005;28:451–3.
PubMed
Google Scholar
Sung KC. Seasonal variation of C-reactive protein in apparently healthy Koreans. Int J Cardiol. 2006;107:338–42.
PubMed
Google Scholar
Liu B, Taioli E. Seasonal variations of complete blood count and inflammatory biomarkers in the US population - analysis of NHANES data. PLoS One. 2015;10:e0142382.
PubMed
PubMed Central
Google Scholar
Kumae T, Sugawara K, Machida K, Shimaoka A. Seasonal changes in immune function. 1. Seasonal changes in the levels of immunoglobulins, complements and some proteins. Jpn J Biometeor. 1986;23:19–27.
Google Scholar
Arima H, Kubo M, Yonemoto K, Doi Y, Ninomiya T, Tanizaki Y, et al. High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study. Arterioscler Thromb Vasc Biol. 2008;28:1385–91.
PubMed
CAS
Google Scholar
Iso H, Noda H, Ikeda A, Yamagishi K, Inoue M, Iwasaki M, et al. The impact of C-reactive protein on risk of stroke, stroke subtypes, and ischemic heart disease in middle-aged Japanese: the Japan public health center-based study. J Atheroscler Thromb. 2012;19:756–66.
PubMed
CAS
Google Scholar
Doi Y, Kiyohara Y, Kubo M, Ninomiya T, Wakugawa Y, Yonemoto K, et al. Elevated C-reactive protein is a predictor of the development of diabetes in a general Japanese population: the Hisayama study. Diabetes Care. 2005;28:2497–500.
PubMed
CAS
Google Scholar
Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997;336:973–9.
PubMed
CAS
Google Scholar
Mizoguchi M, Tahara N, Tahara A, Nitta Y, Kodama N, Oba T, et al. Pioglitazone attenuates atherosclerotic plaque inflammation in patients with impaired glucose tolerance or diabetes a prospective, randomized, comparator-controlled study using serial FDG PET/CT imaging study of carotid artery and ascending aorta. JACC Cardiovasc Imaging. 2011;4:1110–8.
PubMed
Google Scholar
Rothwell PM, Price JF, Fowkes FG, Zanchetti A, Roncaglioni MC, Tognoni G, et al. Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials. Lancet. 2012;379:1602–12.
PubMed
CAS
Google Scholar
Vaishnaw AK, Mitchell TJ, Rose SJ, Walport MJ, Morley BJ. Regulation of transcription of the TATA-less human complement component C4 gene. J Immunol. 1998;160:4353–60.
PubMed
CAS
Google Scholar
Mizuguchi J, Hu CH, Cao Z, Loeb KR, Chung DW, Davie EW. Characterization of the 5′-flanking region of the gene for the gamma chain of human fibrinogen. J Biol Chem. 1995;270:28350–6.
PubMed
CAS
Google Scholar
Dalmon J, Laurent M, Courtois G. The human beta fibrinogen promoter contains a hepatocyte nuclear factor 1-dependent interleukin-6-responsive element. Mol Cell Biol. 1993;13:1183–93.
PubMed
PubMed Central
CAS
Google Scholar
Duan HO, Simpson-Haidaris PJ. Functional analysis of interleukin 6 response elements (IL-6REs) on the human gamma-fibrinogen promoter: binding of hepatic Stat3 correlates negatively with transactivation potential of type II IL-6REs. J Biol Chem. 2003;278:41270–81.
PubMed
CAS
Google Scholar
Falus A, Rokita H, Walcz E, Brozik M, Hidvégi T, Merétey K. Hormonal regulation of complement biosynthesis in human cell lines--II. Upregulation of the biosynthesis of complement components C3, factor B and C1 inhibitor by interleukin-6 and interleukin-1 in human hepatoma cell line. Mol Immunol. 1990;27:197–201.
PubMed
CAS
Google Scholar
Sartain SE, Turner NA, Moake JL. TNF regulates essential alternative complement pathway components and impairs activation of protein C in human glomerular endothelial cells. J Immunol. 2016;196:832–45.
PubMed
CAS
Google Scholar
Rein-Smith CM, Anderson NW, Farrell DH. Differential regulation of fibrinogen γ chain splice isoforms by interleukin-6. Thromb Res. 2013;131:89–93.
PubMed
CAS
Google Scholar
Okuda-Hanafusa C, Uchio R, Fuwa A, Kawasaki K, Muroyama K, Ymamoto Y, et al. Turmeronol a and turmeronol B from Curcuma longa prevent inflammatory mediator production by lipopolysaccharide-stimulated RAW264.7 macrophages, partially via reduced NF-κB signaling. Food Funct. 2019;10:5779–88.
PubMed
CAS
Google Scholar
Testa MA, Simonson DC. Assessment of quality-of-life outcomes. N Engl J Med. 1996;334:835–40.
PubMed
CAS
Google Scholar
Garvin P, Nilsson E, Ernerudh J, Kristenson M. The joint subclinical elevation of CRP and IL-6 is associated with lower health-related quality of life in comparison with no elevation or elevation of only one of the biomarkers. Qual Life Res. 2016;25:213–21.
PubMed
Google Scholar
Lacourt TE, Vichaya EG, Chiu GS, Dantzer R, Heijnen CJ. The high costs of low-grade inflammation: persistent fatigue as a consequence of reduced cellular-energy availability and non-adaptive energy expenditure. Front Behav Neurosci. 2018;12:78.
PubMed
PubMed Central
Google Scholar
Liukkonen T. Low-grade inflammation in depression, Anxiety and Sleep Disturbances: University of Oulu; 2011.
Seiler A, Murdock KW, Fagundes CP. Impaired mental health and low-grade inflammation among fatigued bereaved individuals. J Psychosom Res. 2018;112:40–6.
PubMed
Google Scholar
Cho HJ, Kivimäki M, Bower JE, Irwin MR. Association of C-reactive protein and interleukin-6 with new-onset fatigue in the Whitehall II prospective cohort study. Psychol Med. 2013;43:1773–83.
PubMed
CAS
Google Scholar
Al-Hakeim HK. Serum cortisol, immunoglobulins and some complements among depressed patients. Indian J Clin Biochem. 2008;23:76–80.
PubMed
PubMed Central
CAS
Google Scholar
Boix-Castejón M, Herranz-López M, Gago AP, Olivares-Vicente M, Caturla N, Roche E, et al. Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial. Food Funct. 2018;9:3173–84.
PubMed
Google Scholar
Morita H, Ikeda T, Kajita K, Fujioka K, Mori I, Okada H, et al. Effect of royal jelly ingestion for six months on healthy volunteers. Nutr J. 2012;11:77.
PubMed
PubMed Central
CAS
Google Scholar
Miller GE, Rohleder N, Stetler C, Kirschbaum C. Clinical depression and regulation of the inflammatory response during acute stress. Psychosom Med. 2005;67:679–87.
PubMed
CAS
Google Scholar
Childs E, Van Dam NT, de Wit H. Effects of acute progesterone administration upon responses to acute psychosocial stress in men. Exp Clin Psychopharmacol. 2010;18:78–86.
PubMed
PubMed Central
CAS
Google Scholar
Slavich GM, Irwin MR. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull. 2014;140:774–815.
PubMed
PubMed Central
Google Scholar
Jin SE, Ha H, Shin HK. Effects of herbal formulas Bojungikgi-tang and Palmijihwang-hwan on inflammation in RAW 264.7 cells and the activities of drug-metabolizing enzymes in human hepatic Microsomes. J Med Food. 2018;21:1173–87.
PubMed
CAS
Google Scholar
Satoh N, Sakai S, Kogure T, Tahara E, Origasa H, Shimada Y, et al. A randomized double blind placebo-controlled clinical trial of Hochuekkito, a traditional herbal medicine, in the treatment of elderly patients with weakness N of one and responder restricted design. Phytomedicine. 2005;12:549–54.
PubMed
CAS
Google Scholar
Felger JC. Imaging the role of inflammation in mood and anxiety-related disorders. Curr Neuropharmacol. 2018;16:533–58.
PubMed
PubMed Central
CAS
Google Scholar
Réus GZ, Fries GR, Stertz L, Badawy M, Passos IC, Barichello T, et al. The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders. Neuroscience. 2015;300:141–54.
PubMed
Google Scholar
Hopper AT, Jones KA, Campbell BM, Li G. Neuroinflammation in mood disorders: mechanisms and drug targets. Annu Rep Med Chem. 2013;48:317–31.
CAS
Google Scholar
Rosenblat JD, McIntyre RS. Efficacy and tolerability of minocycline for depression: a systematic review and meta-analysis of clinical trials. J Affect Disord. 2018;227:219–25.
PubMed
CAS
Google Scholar
Kim JE, Shrestha AC, Kim HS, Ham HN, Kim JH, Kim YJ, et al. WS-5 extract of Curcuma longa, Chaenomeles sinensis, and Zingiber officinale contains anti-AChE compounds and improves β-amyloid-induced memory impairment in mice. Evid Based Complement Alternat Med. 2019;2019:5160293.
PubMed
PubMed Central
Google Scholar
Xu J, Ji F, Kang J, Wang H, Li S, Jin DQ, et al. Absolute configurations and NO inhibitory activities of Terpenoids from Curcuma longa. J Agric Food Chem. 2015;63:5805–12.
PubMed
CAS
Google Scholar
Vasileva LV, Saracheva K, Ivanovska MV, Petrova AP, Sucouglu E, Murdjeva MA, et al. Beneficial Effect of Chronic Treatment with Extracts from Rhodiola Rosea L. and Curcuma Longa L. on the Immunoreactivity of Animals Subjected to a Chronic Mild Stress Model. Folia Med (Plovdiv). 2017;59:443–53.
CAS
Google Scholar
Ibironke G, Alemonu O. Effects of ethanol extract of curcuma longa rhizome on Neurobehavioural activities in stressed rats. Afr J Biomed Res. 2013;16:193–7.
Google Scholar
Kumar A, Singh A. Possible nitric oxide modulation in protective effect of (Curcuma longa, Zingiberaceae) against sleep deprivation-induced behavioral alterations and oxidative damage in mice. Phytomedicine. 2008;15:577–86.
PubMed
CAS
Google Scholar