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Table 5 Effect of Curcuma longa extract (CLE) on serum inflammatory markersa

From: Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial

  Change from baseline Repeated measures two-way ANOVA
Week 4 Week 8 Week 12 Group Time Interaction
Mean SD Mean SD Mean SD
CRP, mg/dL
 Placebo 0.019 0.044 0.036 0.091 0.016 0.047 0.057 0.363 0.302
 CLE 0.021 0.089 0.002 0.032 −0.007* 0.035
C3, mg/dL
 Placebo 4.13 7.94 0.10 9.33 7.26 9.00 0.514 < 0.001 0.138
 CLE 4.00 8.14 1.41 11.90 2.66* 8.20
C4, mg/dL
 Placebo 0.06 2.78 0.71 3.57 1.48 3.47 0.366 0.094 0.135
 CLE 0.28 2.58 −0.07 3.42 0.34 2.69
Fibrinogen, mg/dL
 Placebo 9.0 27.9 11.4 46.3 15.1 35.5 0.648 0.371 0.950
 CLE 5.3 50.6 3.7 29.7 12.0 37.8
  1. CRP: C-reactive protein; C3: complement component 3; C4: complement component 4
  2. aValues represent the means and standard deviations at 4, 8, and 12 weeks for n = 31, 31, and 31 (placebo group) or n = 29, 27, and 29 (CLE group), respectively. *p < 0.05: Significant difference from the placebo group by repeated measures two-way ANOVA, followed by the two-tailed unpaired Student’s t test when variance was homogeneous or the Aspin-Welch t test when variance was heterogeneous