Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial

Table 6 Effect of Curcuma longa extract (CLE) on the MOS 36-Item Short-Form Health Survey (SF-36) scores^a

	Change from baseline						Repeated measures two-way ANOVA
	Week 4		Week 8		Week 12		Group	Time	Interaction
	Mean	SD	Mean	SD	Mean	SD	Group	Time	Interaction
Physical functioning (PF)
Placebo	1.00	7.18	0.38	7.20	0.25	6.20	0.768	0.081	0.343
CLE	0.77	5.91	1.71	5.61	0.64	7.18	0.768	0.081	0.343
Role physical (RP)
Placebo	1.25	10.60	0.78	12.10	1.87	8.27	0.719	0.158	0.538
CLE	−0.65	12.40	0.16	9.36	2.24	10.08	0.719	0.158	0.538
Bodily pain (BP)
Placebo	−0.8	14.0	−2.0	14.3	−2.1	11.4	0.544	0.612	0.999
CLE	−2.4	14.9	−3.1	13.9	−3.7	15.6	0.544	0.612	0.999
General health (GH)
Placebo	−0.30	10.99	0.18	13.35	0.63	11.71	0.121	0.881	0.884
CLE	−3.08	9.73	−3.58	10.91	−3.05	12.80	0.121	0.881	0.884
Vitality (VT)
Placebo	−2.51	14.36	−0.94	11.88	1.71	10.49	0.692	0.040	0.734
CLE	−2.56	13.28	−1.32	11.99	−0.32	11.99	0.692	0.040	0.734
Social functioning (SF)
Placebo	−0.94	13.69	0.31	14.57	−0.63	13.56	0.438	0.221	0.749
CLE	0.32	18.02	3.95	14.85	1.92	12.35	0.438	0.221	0.749
Role emotional (RE)
Placebo	0.63	11.99	0.84	12.20	1.04	12.27	0.924	0.648	0.850
CLE	−0.21	13.04	0.88	11.76	1.49	11.78	0.924	0.648	0.850
Mental health (MH)
Placebo	−3.63	10.50	−3.38	11.29	−1.75	9.37	0.032	0.127	0.416
CLE	−0.90	9.86	2.89*	10.24	1.92	10.68	0.032	0.127	0.416
Physical component summary (PCS)
Placebo	1.22	4.85	0.77	4.66	0.54	3.67	0.574	0.836	0.491
CLE	0.23	4.97	0.28	4.02	0.52	4.63	0.574	0.836	0.491
Mental component summary (MCS)
Placebo	−1.76	5.10	−1.18	5.33	−0.38	4.39	0.618	0.144	0.766
CLE	−1.21	5.72	−0.10	4.55	−0.37	5.24	0.618	0.144	0.766

^aValues represent the means and standard deviations for n = 40 (placebo group) or n = 39 (CLE group). *p < 0.05: Significant difference from the placebo group by repeated measures two-way ANOVA, followed by the two-tailed unpaired Student’s t test when variance was homogeneous or the Aspin-Welch t test when variance was heterogeneous

ISSN: 1475-2891