Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial

Table 7 Effect of Curcuma longa extract (CLE) on the Profile of Mood States (POMS) scores^a

	Change from baseline						Repeated measures two-way ANOVA
	Week 4		Week 8		Week 12		Group	Time	Interaction
	Mean	SD	Mean	SD	Mean	SD	Group	Time	Interaction
Anger-hostility (AH)
Placebo	1.95	4.76	1.55	6.02	1.75	5.29	0.022	0.706	0.472
CLE	−0.69*	5.37	0.16	6.01	−1.10*	5.40	0.022	0.706	0.472
Confusion-bewilderment (CB)
Placebo	−0.10	4.80	0.82	6.16	0.00	4.54	0.885	0.956	0.367
CLE	−0.64	4.37	0.71	5.93	−0.97	4.49	0.885	0.956	0.367
Depression-dejection (DD)
Placebo	0.90	4.42	0.53	4.86	0.35	5.37	0.312	0.287	0.285
CLE	−0.64	4.37	0.71	5.93	−0.97	4.49	0.312	0.287	0.285
Fatigue-inertia (FI)
Placebo	−0.03	4.81	−0.70	4.87	−0.25	5.23 6.82	0.900	0.433	0.294
CLE	−0.05	6.73	0.11	7.05	−1.46	5.23 6.82	0.900	0.433	0.294
Tension-anxiety (TA)
Placebo	−1.70	7.77	−2.58	6.00	−1.48	6.99	0.331	0.469	0.108
CLE	0.10	7.36	−0.18	7.00	−1.90	6.69	0.331	0.469	0.108
Vigor-activity (VA)
Placebo	1.58	7.19	1.08	8.23	2.10	8.74	0.141	0.184	0.841
CLE	−0.23	5.94	−1.55	6.20	0.13	7.81	0.141	0.184	0.841
Friendliness (F)
Placebo	0.05	8.19	−0.63	9.62	− 0.33	8.46	0.983	0.706	0.989
CLE	0.00	7.19	−0.45	7.83	−0.15	8.79	0.983	0.706	0.989
Total mood disturbance (TMD)
Placebo	−0.05	4.62	−0.65	4.15	−0.28	3.89	0.894	0.374	0.109
CLE	−0.23	5.04	0.68	6.54	−1.08	5.48	0.894	0.374	0.109

^aValues represent the means and standard deviations for n = 40 (placebo group) or n = 39 (CLE group). *p < 0.05: Significant difference from the placebo group by repeated measures two-way ANOVA, followed by the two-tailed unpaired Student’s t test when variance was homogeneous or the Aspin-Welch t test when variance was heterogeneous

ISSN: 1475-2891