Yki-Järvinen H. Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome. Lancet Diabetes Endocrinol. 2014;2(11):901–10. https://doi.org/10.1016/S2213-8587(14)70032-4.
Article
CAS
PubMed
Google Scholar
Zhou F, Zhou J, Wang W, Zhang XJ, Ji YX, Zhang P, et al. Unexpected rapid increase in the burden of NAFLD in China from 2008 to 2018: a systematic review and meta-analysis. Hepatology. 2019;70(4):1119–33. https://doi.org/10.1002/hep.30702.
Article
PubMed
Google Scholar
Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2018;67(1):328–57. https://doi.org/10.1002/hep.29367.
Article
PubMed
Google Scholar
Degasperi E, Colombo M. Distinctive features of hepatocellular carcinoma in non-alcoholic fatty liver disease. Lancet Gastroenterol Hepatol. 2016;1(2):156–64. https://doi.org/10.1016/S2468-1253(16)30018-8.
Article
PubMed
Google Scholar
Hagström H, Nasr P, Ekstedt M, Hammar U, Stål P, Askling J, et al. Cardiovascular risk factors in non-alcoholic fatty liver disease. Liver Int. 2019;39(1):197–204. https://doi.org/10.1111/liv.13973.
Article
PubMed
Google Scholar
Jarvis H, Craig D, Barker R, Spiers G, Stow D, Anstee QM, et al. Metabolic risk factors and incident advanced liver disease in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of population-based observational studies. PLoS Med. 2020;17(4):e1003100. https://doi.org/10.1371/journal.pmed.1003100.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li H, Hu B, Wei L, Zhou L, Zhang L, Lin Y, et al. Non-alcoholic fatty liver disease is associated with stroke severity and progression of brainstem infarctions. Eur J Neurol. 2018;25(3):577–e34. https://doi.org/10.1111/ene.13556.
Article
CAS
PubMed
Google Scholar
Adams LA, Anstee QM, Tilg H, Targher G. Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases. Gut. 2017;66(6):1138–53. https://doi.org/10.1136/gutjnl-2017-313884.
Article
PubMed
Google Scholar
Younossi ZM. Non-alcoholic fatty liver disease - a global public health perspective. J Hepatol. 2019;70(3):531–44. https://doi.org/10.1016/j.jhep.2018.10.033.
Article
PubMed
Google Scholar
Polyzos SA, Kountouras J, Mantzoros CS. Obesity and nonalcoholic fatty liver disease: from pathophysiology to therapeutics. Metabolism. 2019;92:82–97. https://doi.org/10.1016/j.metabol.2018.11.014.
Article
CAS
PubMed
Google Scholar
Zou B, Yeo YH, Nguyen VH, Cheung R, Ingelsson E, Nguyen MH. Prevalence, characteristics and mortality outcomes of obese, nonobese and lean NAFLD in the United States, 1999-2016. J Intern Med. 2020;288(1):139–51. https://doi.org/10.1111/joim.13069.
Article
CAS
PubMed
Google Scholar
Fan JG, Kim SU, Wong VW. New trends on obesity and NAFLD in Asia. J Hepatol. 2017;67(4):862–73. https://doi.org/10.1016/j.jhep.2017.06.003.
Article
PubMed
Google Scholar
Xu C, Yu C, Ma H, Xu L, Miao M, Li Y. Prevalence and risk factors for the development of nonalcoholic fatty liver disease in a nonobese Chinese population: the Zhejiang Zhenhai study. Am J Gastroenterol. 2013;108(8):1299–304. https://doi.org/10.1038/ajg.2013.104.
Article
PubMed
Google Scholar
Hagström H, Nasr P, Ekstedt M, Hammar U, Stål P, Hultcrantz R, et al. Risk for development of severe liver disease in lean patients with nonalcoholic fatty liver disease: a long-term follow-up study. Hepatol Commun. 2018;2(1):48–57. https://doi.org/10.1002/hep4.1124.
Article
CAS
PubMed
Google Scholar
Zeng J, Yang RX, Sun C, Pan Q, Zhang RN, Chen GY, et al. Prevalence, clinical characteristics, risk factors, and indicators for lean Chinese adults with nonalcoholic fatty liver disease. World J Gastroenterol. 2020;26(15):1792–804. https://doi.org/10.3748/wjg.v26.i15.1792.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liu S, Liu Y, Wan B, Zhang H, Wu S, Zhu Z, et al. Association between vitamin D status and non-alcoholic fatty liver disease: a population-based study. J Nutr Sci Vitaminol. 2019;65(4):303–8. https://doi.org/10.3177/jnsv.65.303.
Article
CAS
PubMed
Google Scholar
Zhai HL, Wang NJ, Han B, Li Q, Chen Y, Zhu CF, et al. Low vitamin D levels and non-alcoholic fatty liver disease, evidence for their independent association in men in East China: a cross-sectional study (survey on prevalence in East China for metabolic diseases and risk factors (SPECT-China)). Brit J Nutr. 2016;115(8):1352–9. https://doi.org/10.1017/S0007114516000386.
Article
CAS
PubMed
Google Scholar
Bhatt SP, Nigam P, Misra A, Guleria R, Qadar Pasha MA. Independent associations of low 25 hydroxy vitamin D and high parathyroid hormonal levels with nonalcoholic fatty liver disease in Asian Indians residing in North India. Atherosclerosis. 2013;230(1):157–63. https://doi.org/10.1016/j.atherosclerosis.2013.07.006.
Article
CAS
PubMed
Google Scholar
Ha Y, Hwang SG, Rim KS. The association between vitamin D insufficiency and nonalcoholic fatty liver disease: a population-based study. Nutrients. 2017;9(8):806.
Article
PubMed Central
Google Scholar
Hao YP, Ma XJ, Luo YQ, Ni J, Dou JX, Hu YQ, et al. Serum vitamin D is associated with non-alcoholic fatty liver disease in Chinese males with normal weight and liver enzymes. Acta Pharmacol Sin. 2014;35(9):1150–6. https://doi.org/10.1038/aps.2014.48.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cordeiro A, Pereira S, Saboya CJ, Ramalho A. Relationship between nonalcoholic fatty liver disease and vitamin D nutritional status in extreme obesity. Can J Gastroenterol Hepatol. 2017;2017:9456897.
Article
PubMed
PubMed Central
Google Scholar
Zhang H, Shen Z, Lin Y, Zhang J, Zhang Y, Liu P, et al. Vitamin D receptor targets hepatocyte nuclear factor 4α and mediates protective effects of vitamin D in nonalcoholic fatty liver disease. J Biol Chem. 2020;295(12):3891–905. https://doi.org/10.1074/jbc.RA119.011487.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lorvand Amiri H, Agah S, Tolouei Azar J, Hosseini S, Shidfar F, Mousavi SN. Effect of daily calcitriol supplementation with and without calcium on disease regression in non-alcoholic fatty liver patients following an energy-restricted diet: randomized, controlled, double-blind trial. Clin Nutr. 2017;36(6):1490–7. https://doi.org/10.1016/j.clnu.2016.09.020.
Article
CAS
PubMed
Google Scholar
Papapostoli I, Lammert F, Stokes CS. Effect of short-term vitamin D correction on hepatic Steatosis as quantified by controlled attenuation parameter (CAP). J Gastrointestin Liver Dis. 2016;25(2):175–81. https://doi.org/10.15403/jgld.2014.1121.252.cap.
Article
PubMed
Google Scholar
Lu ZY, Cen C, Shao Z, Chen XH, Xu CF, Li YM. Association between serum α-L-fucosidase and non-alcoholic fatty liver disease: cross-sectional study. World J Gastroenterol. 2016;22(5):1884–90. https://doi.org/10.3748/wjg.v22.i5.1884.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lu Z, Ma H, Xu C, Shao Z, Cen C, Li Y. Serum Sialic acid level is significantly associated with nonalcoholic fatty liver disease in a nonobese Chinese population: a cross-sectional study. Biomed Res Int. 2016;2016:5921589.
PubMed
PubMed Central
Google Scholar
WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363(9403):157–63.
Article
Google Scholar
Holick M. Vitamin D deficiency. New Engl J Med. 2007;357(3):266–81. https://doi.org/10.1056/NEJMra070553.
Article
CAS
PubMed
Google Scholar
Alberti KG, Zimmet P, Shaw J. Metabolic syndrome--a new world-wide definition. A consensus statement from the international diabetes federation. Diabet Med. 2006;23(5):469–80. https://doi.org/10.1111/j.1464-5491.2006.01858.x.
Article
CAS
PubMed
Google Scholar
Fan JG, Wei L, Zhuang H. Guidelines of prevention and treatment of nonalcoholic fatty liver disease (2018, China). J Dig Dis. 2019;20(4):163–73. https://doi.org/10.1111/1751-2980.12685.
Article
PubMed
Google Scholar
Rhee EJ, Kim MK, Park SE, Park CY, Baek KH, Lee WY, et al. High serum vitamin D levels reduce the risk for nonalcoholic fatty liver disease in healthy men independent of metabolic syndrome. Endocr J. 2013;60(6):743–52. https://doi.org/10.1507/endocrj.EJ12-0387.
Article
CAS
PubMed
Google Scholar
Jablonski KL, Jovanovich A, Holmen J, Targher G, McFann K, Kendrick J, et al. Low 25-hydroxyvitamin D level is independently associated with non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis. 2013;23(8):792–8. https://doi.org/10.1016/j.numecd.2012.12.006.
Article
CAS
PubMed
PubMed Central
Google Scholar
Eliades M, Spyrou E, Agrawal N, Lazo M, Brancati FL, Potter JJ, et al. Meta-analysis: vitamin D and non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2013;38(3):246–54. https://doi.org/10.1111/apt.12377.
Article
CAS
PubMed
Google Scholar
Nobili V, Giorgio V, Liccardo D, Bedogni G, Morino G, Alisi A, et al. Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease. Eur J Endocrinol. 2014;170(4):547–53. https://doi.org/10.1530/EJE-13-0609.
Article
CAS
PubMed
Google Scholar
Targher G, Bertolini L, Scala L, Cigolini M, Zenari L, Falezza G, et al. Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis. 2007;17(7):517–24. https://doi.org/10.1016/j.numecd.2006.04.002.
Article
CAS
PubMed
Google Scholar
Keane JT, Elangovan H, Stokes RA, Gunton JE. Vitamin D and the liver-correlation or cause? Nutrients. 2018;10(4):496. https://doi.org/10.3390/nu10040496.
Article
CAS
PubMed Central
Google Scholar
Pereira-Santos M, Costa PR, Assis AM, Santos CA, Santos DB. Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obes Rev. 2015;16(4):341–9. https://doi.org/10.1111/obr.12239.
Article
CAS
PubMed
Google Scholar
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30. https://doi.org/10.1210/jc.2011-0385.
Article
CAS
PubMed
Google Scholar
Kwok RM, Torres DM, Harrison SA. Vitamin D and nonalcoholic fatty liver disease (NAFLD): is it more than just an association? Hepatology. 2013;58(3):1166–74. https://doi.org/10.1002/hep.26390.
Article
CAS
PubMed
Google Scholar
Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. 2013;10(2):e1001383. https://doi.org/10.1371/journal.pmed.1001383.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chakraborty A, Choudhury A, Saha A. Development of non-alcoholic fatty liver disease (NAFLD) in young obese tribal subjects of Tripura: link between low 25 (OH) vitamin-D levels and immune modulators. J Assoc Physicians India. 2019;67(8):52–6.
PubMed
Google Scholar
Kong M, Zhu L, Bai L, Zhang X, Chen Y, Liu S, et al. Vitamin D deficiency promotes nonalcoholic steatohepatitis through impaired enterohepatic circulation in animal model. Am J Physiol Gastrointest Liver Physiol. 2014;307(9):G883–93. https://doi.org/10.1152/ajpgi.00427.2013.
Article
CAS
PubMed
PubMed Central
Google Scholar
Barchetta I, Angelico F, Del Ben M, Baroni MG, Pozzilli P, Morini S, et al. Strong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes. BMC Med. 2011;9(1):85. https://doi.org/10.1186/1741-7015-9-85.
Article
CAS
PubMed
PubMed Central
Google Scholar
Akyuz U, Yesil A, Yilmaz Y. Characterization of lean patients with nonalcoholic fatty liver disease: potential role of high hemoglobin levels. Scand J Gastroenterol. 2015;50(3):341–6. https://doi.org/10.3109/00365521.2014.983160.
Article
CAS
PubMed
Google Scholar
Younossi ZM, Stepanova M, Negro F, Hallaji S, Younossi Y, Lam B, et al. Nonalcoholic fatty liver disease in lean individuals in the United States. Medicine. 2012;91(6):319–27. https://doi.org/10.1097/MD.0b013e3182779d49.
Article
PubMed
Google Scholar
Wang AY, Dhaliwal J, Mouzaki M. Lean non-alcoholic fatty liver disease. Clin Nutr. 2019;38(3):975–81. https://doi.org/10.1016/j.clnu.2018.08.008.
Article
CAS
PubMed
Google Scholar