Evans M, Wilson D, Guthrie N. A randomized, double-blind, placebo-controlled, pilot study to evaluate the effect of whole grape extract on antioxidant status and lipid profile. J Funct Foods. 2014;7:680–91.
Article
CAS
Google Scholar
Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K. Oxidative stress, prooxidants, and antioxidants: the interplay. Biomed Res Int. 2014;2014:1–19.
Trachootham D, Lu W, Ogasawara MA, Valle NR-D, Huang P. Redox regulation of cell survival. Antioxid Redox Signal. 2008;10:1343–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ray PD, Huang B-W, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. 2012;24:981–90.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sies H. Role of reactive oxygen species in biological processes. Klin Wochenschr. 1991;69:965–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Knutson MD. Non-transferrin-bound iron transporters. Free Radic Biol Med. 2019;133:101–11.
Article
CAS
PubMed
Google Scholar
Stoian I, Oros A, Moldoveanu E. Apoptosis and free radicals. Biochem Mol Med. 1996;59:93–7.
Article
CAS
PubMed
Google Scholar
Fu S, DAVIES MJ, STOCKER R, DEAN RT. Evidence for roles of radicals in protein oxidation in advanced human atherosclerotic plaque. Biochem J. 1998;333:519–25.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rani V, Deep G, Singh RK, Palle K, Yadav UC. Oxidative stress and metabolic disorders: pathogenesis and therapeutic strategies. Life Sci. 2016;148:183–93.
Article
CAS
PubMed
Google Scholar
Belli R, Amerio P, Brunetti L, Orlando G, Toto P, Proietto G, Vacca M, Tulli A. Elevated 8-isoprostane levels in basal cell carcinoma and in UVA irradiated skin. Int J Immunopathol Pharmacol. 2005;18:497–502.
Article
CAS
PubMed
Google Scholar
Chen J, Zeng L, Xia T, Li S, Yan T, Wu S, Qiu G, Liu Z. Toward a biomarker of oxidative stress: a fluorescent probe for exogenous and endogenous malondialdehyde in living cells. Anal Chem. 2015;87:8052–6.
Article
CAS
PubMed
Google Scholar
Riggins JN, Pratt DA, Voehler M, Daniels JS, Marnett LJ. Kinetics and mechanism of the general-acid-catalyzed ring-closure of the malondialdehyde− DNA adduct, N 2-(3-Oxo-1-propenyl) deoxyguanosine (N 2 OPdG-), to 3-(2 ‘-Deoxy-β-d-erythro-pentofuranosyl) pyrimido [1, 2-α] purin-10 (3 H)-one (M1dG). J Am Chem Soc. 2004;126:10571–81.
Article
CAS
PubMed
Google Scholar
Khoubnasabjafari M, Ansarin K, Jouyban A. Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders. BioImpacts: BI. 2015;5:123.
CAS
PubMed
PubMed Central
Google Scholar
Huang D, Ou B, Hampsch-Woodill M, Flanagan JA. Prior RL: high-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format. J Agric Food Chem. 2002;50:4437–44.
Article
CAS
PubMed
Google Scholar
Cao G. Prior RL: comparison of different analytical methods for assessing total antioxidant capacity of human serum. Clin Chem. 1998;44:1309–15.
Article
CAS
PubMed
Google Scholar
Nagy G, Ward J, Mosser DD, Koncz A, Gergely P, Stancato C, Qian Y, Fernandez D, Niland B, Grossman CE. Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection. J Biol Chem. 2006;281:34574–91.
Article
CAS
PubMed
Google Scholar
Woodford F, Whitehead T. Is measuring serum antioxidant capacity clinically useful? Ann Clin Biochem. 1998;35:48–56.
Article
PubMed
Google Scholar
Albers AR, Varghese S, Vitseva O, Vita JA, Freedman JE. The antiinflammatory effects of purple grape juice consumption in subjects with stable coronary artery disease. Arterioscler Thromb Vasc Biol. 2004;24:e179–80.
Article
CAS
PubMed
Google Scholar
Coimbra S, Lage S, Brandizzi L, Yoshida V, Da Luz P. The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients. Braz J Med Biol Res. 2005;38:1339–47.
Article
CAS
PubMed
Google Scholar
Freedman JE, Parker Iii C, Li L, Perlman JA, Frei B, Ivanov V, Deak LR, Iafrati MD, Folts JD. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation. 2001;103:2792–8.
Article
CAS
PubMed
Google Scholar
O'Byrne DJ, Devaraj S, Grundy SM, Jialal I. Comparison of the antioxidant effects of Concord grape juice flavonoids α-tocopherol on markers of oxidative stress in healthy adults. Am J Clin Nutr. 2002;76:1367–74.
Article
CAS
PubMed
Google Scholar
Zern TL, Wood RJ, Greene C, West KL, Liu Y, Aggarwal D, Shachter NS, Fernandez ML. Grape polyphenols exert a cardioprotective effect in pre-and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr. 2005;135:1911–7.
Article
CAS
PubMed
Google Scholar
Kar P, Laight D, Rooprai H, Shaw K, Cummings M. Effects of grape seed extract in type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabetic Med. 2009;26:526–31.
Article
CAS
PubMed
Google Scholar
Hokayem M, Blond E, Vidal H, Lambert K, Meugnier E, Feillet-Coudray C, Coudray C, Pesenti S, Luyton C, Lambert-Porcheron S. Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients. Diabetes Care. 2013;36:1454–61.
Article
CAS
PubMed
PubMed Central
Google Scholar
Moreno-Indias I, Sánchez-Alcoholado L, Pérez-Martínez P, Andrés-Lacueva C, Cardona F, Tinahones F, Queipo-Ortuño MI. Red wine polyphenols modulate fecal microbiota and reduce markers of the metabolic syndrome in obese patients. Food Funct. 2016;7:1775–87.
Article
PubMed
CAS
Google Scholar
Sano A, Uchida R, Saito M, Shioya N, Komori Y, Tho Y, Hashizume N. Beneficial effects of grape seed extract on malondialdehyde-modified LDL. J Nutr Sci Vitaminol. 2007;53:174–82.
Article
CAS
PubMed
Google Scholar
Krikorian R, Boespflug EL, Fleck DE, Stein AL, Wightman JD, Shidler MD, Sadat-Hossieny S. Concord grape juice supplementation and neurocognitive function in human aging. J Agric Food Chem. 2012;60:5736–42.
Article
CAS
PubMed
Google Scholar
Akhtar S, Meeran SM, Katiyar N, Katiyar SK. Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting insulin-like growth factor binding protein-3, tumor cell proliferation, and angiogenic factors. Clin Cancer Res. 2009;15:821–31.
Article
CAS
PubMed
Google Scholar
Hudson TS, Hartle DK, Hursting SD, Nunez NP, Wang TT, Young HA, Arany P, Green JE. Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms. Cancer Res. 2007;67:8396–405.
Article
CAS
PubMed
Google Scholar
Singletary KW, Jung K-J, Giusti M. Anthocyanin-rich grape extract blocks breast cell DNA damage. J Med Food. 2007;10:244–51.
Article
CAS
PubMed
Google Scholar
Kay CD. The future of flavonoid research. Br J Nutr. 2010;104:S91–5.
Article
CAS
PubMed
Google Scholar
Lu M-C, Yang M-D, Li P-C, Fang H-Y, Huang H-Y, Chan Y-C, Bau D-T. Effect of oligomeric proanthocyanidin on the antioxidant status and lung function of patients with chronic obstructive pulmonary disease. in vivo. 2018;32:753–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Farhadi K, Esmaeilzadeh F, Hatami M, Forough M, Molaie R. Determination of phenolic compounds content and antioxidant activity in skin, pulp, seed, cane and leaf of five native grape cultivars in West Azerbaijan province, Iran. Food Chem. 2016;199:847–55.
Article
CAS
PubMed
Google Scholar
Xia E-Q, Deng G-F, Guo Y-J, Li H-B. Biological activities of polyphenols from grapes. Int J Mol Sci. 2010;11:622–46.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yilmaz Y, Göksel Z, Erdoğan SS, Öztürk A, Atak A, Özer C. Antioxidant activity and phenolic content of seed, skin and pulp parts of 22 grape (V itis vinifera L.) cultivars (4 common and 18 registered or candidate for registration). J Food Processing Preservation. 2015;39:1682–91.
Article
CAS
Google Scholar
Saldanha JF, Leal VO, Rizzetto F, Grimmer GH, Ribeiro-Alves M, Daleprane JB, Carraro-Eduardo JC, Mafra D. Effects of resveratrol supplementation in Nrf2 and NF-κB expressions in nondialyzed chronic kidney disease patients: a randomized, double-blind, placebo-controlled, crossover clinical trial. J Ren Nutr. 2016;26:401–6.
Article
CAS
PubMed
Google Scholar
Hollis JH, Houchins JA, Blumberg JB, Mattes RD. Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults. J Am Coll Nutr. 2009;28:574–82.
Article
CAS
PubMed
Google Scholar
Zunino SJ, Peerson JM, Freytag TL, Breksa AP, Bonnel EL, Woodhouse LR, Storms DH. Dietary grape powder increases IL-1β and IL-6 production by lipopolysaccharide-activated monocytes and reduces plasma concentrations of large LDL and large LDL-cholesterol particles in obese humans. Br J Nutr. 2014;112:369–80.
Article
CAS
PubMed
Google Scholar
Rankin J, Andreae M, Oliver Chen CY, O’keefe S. Effect of raisin consumption on oxidative stress and inflammation in obesity. Diabetes Obes Metab. 2008;10:1086–96.
Article
CAS
PubMed
Google Scholar
Amoutzopoulos B, Löker GB, Samur G, Çevikkalp SA, Yaman M, Köse T, Pelvan E. Effects of a traditional fermented grape-based drink ‘hardaliye’on antioxidant status of healthy adults: a randomized controlled clinical trial. J Sci Food Agric. 2013;93:3604–10.
Article
CAS
PubMed
Google Scholar
El-Dakroory SA, El-Ashry R, Mesbah A, El-Farahaty RM. Doxorubicin Cardiotoxicity in acute lymphoblastic leukemia: possible protective role of grape seed extract Proanthocyanidins. J Advanc Medicine Med Res. 2014:2555–67.
Taghizadeh M, Malekian E, Memarzadeh MR, Mohammadi AA, Asemi Z. Grape seed extract supplementation and the effects on the biomarkers of oxidative stress and metabolic profiles in female volleyball players: a randomized, double-blind, placebo-controlled clinical trial. Iran Red Crescent Med J. 2016;18:1–9.
Kanellos PT, Kaliora AC, Protogerou AD, Tentolouris N, Perrea DN, Karathanos VT. The effect of raisins on biomarkers of endothelial function and oxidant damage; an open-label and randomized controlled intervention. Food Res Int. 2017;102:674–80.
Article
CAS
PubMed
Google Scholar
Pourghassem-Gargari B, Abedini S, Babaei H, Aliasgarzadeh A, Pourabdollahi P. Effect of supplementation with grape seed (Vitis vinifera) extract on antioxidant status and lipid peroxidation in patient with type diabetes. J Medicinal Plants Res. 2011;5:2029–34.
Google Scholar
Macedo R, Vieira A, Marin D, Otton R. Effects of chronic resveratrol supplementation in military firefighters undergo a physical fitness test–a placebo-controlled, double blind study. Chemico-biological interactions. 2015;227:89–95.
Article
CAS
PubMed
Google Scholar
Janiques AGPR, Leal VO, Stockler-Pinto MB, Moreira NX, Mafra D. Effects of grape powder supplementation on inflammatory and antioxidant markers in hemodialysis patients: a randomized double-blind study. Brazilian J Nephrol. 2014;36:496–501.
Article
Google Scholar
Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1.
Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, Savović J, Schulz KF, Weeks L, Sterne JA. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. Bmj. 2011;343:d5928.
Article
PubMed
PubMed Central
Google Scholar
DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.
Article
CAS
PubMed
Google Scholar
Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. Bmj. 2003;327:557–60.
Article
PubMed
PubMed Central
Google Scholar
Hassimotto NMA, Moreira V, Nascimento NG, Souto PCMC, Teixeira C, Lajolo FM. Inhibition of carrageenan-induced acute inflammation in mice by oral administration of anthocyanin mixture from wild mulberry and cyanidin-3-glucoside. Biomed Res Int. 2013;2013:1–10.
Amiot MJ, Riva C, Vinet A. Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review. Obes Rev. 2016;17:573–86.
Article
CAS
PubMed
Google Scholar
Castelli T, Russo GI, Reale G, Privitera S, Chisari M, Fragala E, Favilla V, Cimino S, Morgia G. Metabolic syndrome and prostatic disease: potentially role of polyphenols in preventive strategies. A review. International Braz J Urol. 2016;42:422–30.
Article
PubMed
PubMed Central
Google Scholar
Guasch-Ferré M, Merino J, Sun Q, Fitó M, Salas-Salvadó J. Dietary polyphenols, Mediterranean diet, Prediabetes, and type 2 diabetes: a narrative review of the evidence. Oxidative Med Cell Longev. 2017;2017:1–16.
Chiva-Blanch G, Badimon L. Effects of polyphenol intake on metabolic syndrome: current evidences from human trials. Oxidative Med Cell Longev. 2017;2017:1–19.
Li SH, Tian HB, Zhao HJ, Chen LH, Cui LQ. The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials. PLoS One. 2013;8:1–10.
Li SH, Zhao P, Tian HB, Chen LH, Cui LQ. Effect of grape polyphenols on blood pressure: a meta-analysis of randomized controlled trials. PLoS One. 2015;10:1–12.
Li Y, Li S, Meng X, Gan R-Y, Zhang J-J, Li H-B. Dietary natural products for prevention and treatment of breast cancer. Nutrients. 2017;9:728.
Article
PubMed Central
CAS
Google Scholar
Santhakumar AB, Battino M, Alvarez-Suarez JM. Dietary polyphenols: structures, bioavailability and protective effects against atherosclerosis. Food Chem Toxicol. 2018;113:49–65.
Article
CAS
PubMed
Google Scholar
Marx W, Kelly J, Marshall S, Nakos S, Campbell K, Itsiopoulos C. The effect of polyphenol-rich interventions on cardiovascular risk factors in Haemodialysis: a systematic review and meta-analysis. Nutrients. 2017;9:1–24.
Yasueda A, Urushima H, Ito T. Efficacy and interaction of antioxidant supplements as adjuvant therapy in Cancer treatment: a systematic review. Integrative Cancer Therapies. 2016;15:17–39.
Article
CAS
PubMed
Google Scholar
Suen J, Thomas J, Kranz A, Vun S, Miller M. Effect of flavonoids on oxidative stress and inflammation in adults at risk of cardiovascular disease: a systematic review. Healthcare. 2016;4:1–23.
Sequeira IR, Poppitt SD. Unfolding novel mechanisms of polyphenol flavonoids for better glycaemic control: targeting pancreatic islet amyloid polypeptide (IAPP). Nutrients. 2017;9:788.
Article
PubMed Central
CAS
Google Scholar
Bonnefont-Rousselot D. Resveratrol and cardiovascular diseases. Nutrients. 2016;8:1–24.
Sahebkar A. Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2013;71:822–35.
Article
PubMed
Google Scholar
Malhotra A, Bath S, Elbarbry F. An organ system approach to explore the antioxidative, anti-inflammatory, and cytoprotective actions of resveratrol. Oxidative Med Cell Longev. 2015;2015:1–15.
Pannu N, Bhatnagar A. Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases. Biomed Pharmacother. 2019;109:2237–51.
Article
CAS
PubMed
Google Scholar
Huang J, Wang X, Zhang Y. Specific types of alcoholic beverage consumption and risk of type 2 diabetes: a systematic review and meta-analysis. J Diab Investigation. 2017;8:56–68.
Article
Google Scholar
Barbhaiya M, Lu B, Sparks JA, Malspeis S, Chang SC, Karlson EW, Costenbader KH. Influence of alcohol consumption on the risk of systemic lupus erythematosus among women in the nurses’ health study cohorts. Arthritis care & research. 2017;69:384–92.
Article
Google Scholar
Di Castelnuovo A, Costanzo S, Di Giuseppe R, De Gaetano G, Iacoviello L. Alcohol consumption and cardiovascular risk: mechanisms of action and epidemiologic perspectives. Futur Cardiol. 2009;5:467–77.
Article
Google Scholar
Jung S, Wang M, Anderson K, Baglietto L, Bergkvist L, Bernstein L, van den Brandt PA, Brinton L, Buring JE, Heather Eliassen A. Alcohol consumption and breast cancer risk by estrogen receptor status: in a pooled analysis of 20 studies. Int J Epidemiol. 2016;45:916–28.
Article
PubMed
Google Scholar
Peters R, Peters J, Warner J, Beckett N, Bulpitt C. Alcohol, dementia and cognitive decline in the elderly: a systematic review. Age Ageing. 2008;37:505–12.
Article
PubMed
Google Scholar
Rimm EB, Williams P, Fosher K, Criqui M, Stampfer MJ. Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. Bmj. 1999;319:1523–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shen Z, Li Y-M, Yu C-H, Shen Y, Xu L, Xu C-F, Chen J-J, Ye H, Xu G-Y. Risk factors for alcohol-related liver injury in the island population of China: a population-based case-control study. World J Gastroenterol: WJG. 2008;14:2255.
Article
PubMed
PubMed Central
Google Scholar
Van de Wiel A, De Lange D. Cardiovascular risk is more related to drinking pattern than to the type of alcoholic drinks. Neth J Med. 2008;66:467–73.
PubMed
Google Scholar
Wang PL, Xiao FT, Gong BC, Liu FN. Alcohol drinking and gastric cancer risk: a meta-analysis of observational studies. Oncotarget. 2017;8:99013–23.
Article
PubMed
PubMed Central
Google Scholar
Xu W, Wang H, Wan Y, Tan C, Li J, Tan L. Yu JT: alcohol consumption and dementia risk: a dose–response meta-analysis of prospective studies. Eur J Epidemiol. 2017;32:31–42.
Article
PubMed
Google Scholar
Briggs NC, Levine RS, Bobo LD, Haliburton WP, Brann EA, Hennekens CH. Wine drinking and risk of non-Hodgkin’s lymphoma among men in the United States: a population-based case-control study. Am J Epidemiol. 2002;156:454–62.
Article
PubMed
Google Scholar
Rodrigo R, Miranda A, Vergara L. Modulation of endogenous antioxidant system by wine polyphenols in human disease. Clin Chim Acta. 2011;412:410–24.
Article
CAS
PubMed
Google Scholar
Cueva C, Gil-Sánchez I, Ayuda-Durán B, González-Manzano S, González-Paramás AM, Santos-Buelga C, Bartolomé B, Moreno-Arribas M. An integrated view of the effects of wine polyphenols and their relevant metabolites on gut and host health. Molecules. 2017;22:99.
Article
PubMed Central
CAS
Google Scholar
Petersen K, Smith C. Ageing-associated oxidative stress and inflammation are alleviated by products from grapes. Oxidative Med Cell Longev. 2016;2016:1–12.
Rasines-Perea Z, Teissedre PL. Grape Polyphenols' effects in human cardiovascular diseases and diabetes. Molecules. 2017;22:1–19.
Zhang H, Liu S, Li L, Liu S, Liu S, Mi J, Tian G. The impact of grape seed extract treatment on blood pressure changes: a meta-analysis of 16 randomized controlled trials. Medicine. 2016;95:1–7.
Wightman JD, Heuberger RA. Effect of grape and other berries on cardiovascular health. J Sci Food Agric. 2015;95:1584–97.
Article
CAS
PubMed
Google Scholar
Pérez-Jiménez J, Saura-Calixto F. Grape products and cardiovascular disease risk factors. Nutr Res Rev. 2008;21:158–73.
Article
PubMed
CAS
Google Scholar
Di Lorenzo C, de Sousa LP, Pastor RF, Colombo F, Frigerio G, Restani P. Beneficial effects of non-alcoholic grape-derived products on human health: a literature review. In: BIO Web of Conferences. EDP Sciences; 2015. p. 04002.
Google Scholar
Akaberi M, Hosseinzadeh H. Grapes (Vitis vinifera) as a potential candidate for the therapy of the metabolic syndrome. Phytother Res. 2016;30:540–56.
Article
CAS
PubMed
Google Scholar
Zheng J, Zhou Y, Li S, Zhang P, Zhou T, Xu D-P, Li H-B. Effects and mechanisms of fruit and vegetable juices on cardiovascular diseases. Int J Mol Sci. 2017;18:555.
Article
PubMed Central
CAS
Google Scholar
Alipour M, Davoudi P, Davoudi Z. Effects of unripe grape juice (verjuice) on plasma lipid profile, blood pressure, malondialdehyde and total antioxidant capacity in normal, hyperlipidemic and hyperlipidemic with hypertensive human volunteers. J Medicinal Plants Res. 2012;6:5677–83.
CAS
Google Scholar
Apostolidou C, Adamopoulos K, Iliadis S, Kourtidou-Papadeli C. Alterations of antioxidant status in asymptomatic hypercholesterolemic individuals after resveratrol intake. Int J Food Sci Nutr. 2016;67:541–52.
Article
CAS
Google Scholar
Barona J, Blesso CN, Andersen CJ, Park Y, Lee J, Fernandez ML. Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome. Nutrients. 2012;4:1945–57.
Article
CAS
PubMed
PubMed Central
Google Scholar
Copetti C, Franco FW, EdR M, Soquetta MB, Quatrin A, VdM R, JCF M, Emanuelli T, Sautter CK, Penna NG. Acute consumption of bordo grape juice and wine improves serum antioxidant status in healthy individuals and inhibits reactive oxygen species production in human neuron-like cells. J nutri metabol. 2018;2018:1–11.
de Rijke YB, Demacker P, Assen NA, Sloots LM, Katan MB, Stalenhoef A. Red wine consumption does not affect oxidizability of low-density lipoproteins in volunteers. Am J Clin Nutr. 1996;63:329–34.
Article
PubMed
Google Scholar
Di Renzo L, Carraro A, Valente R, Iacopino L, Colica C, De Lorenzo A. Intake of red wine in different meals modulates oxidized LDL level, oxidative and inflammatory gene expression in healthy people: a randomized crossover trial. Oxidative Med Cell Longev. 2014:2014:1–9.
Fuhrman B, Lavy A, Aviram M. Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation. Am J Clin Nutr. 1995;61:549–54.
Article
CAS
PubMed
Google Scholar
Kalfin R, Righi A, Del Rosso A, Bagchi D, Generini S, Guiducci S, Matucci Cerinic M, Das DK. Activin, a grape seed-derived proanthocyanidin extract, reduces plasma levels of oxidative stress and adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in systemic sclerosis. Free Radic Res. 2002;36:819–25.
Article
CAS
Google Scholar
Micallef M, Lexis L, Lewandowski P. Red wine consumption increases antioxidant status and decreases oxidative stress in the circulation of both young and old humans. Nutr J. 2007;6:27.
Article
PubMed
PubMed Central
CAS
Google Scholar
Neto MM, da Silva TF, de Lima FF, Siqueira TM, Toscano LT, de Moura SK, Silva AS. Whole red grape juice reduces blood pressure at rest and increases post-exercise hypotension. J Am Coll Nutr. 2017;36:533–40.
Article
PubMed
CAS
Google Scholar
Paller CJ, Zhou XC, Heath EI, Taplin M-E, Mayer T, Stein MN, Bubley GJ, Pili R, Hudson T, Kakarla R. Muscadine grape skin extract (MPX) in men with biochemically recurrent prostate cancer: a randomized, multicenter, placebo-controlled clinical trial. Clin Cancer Res. 2018;24:306–15.
Article
CAS
PubMed
Google Scholar
Safaei N, Babaei H, Azarfarin R, Jodati A-R, Yaghoubi A, Sheikhalizadeh M-A. Comparative effect of grape seed extract (Vitis vinifera) and ascorbic acid in oxidative stress induced by on-pump coronary artery bypass surgery. Ann Card Anaesth. 2017;20:45.
Article
PubMed
PubMed Central
Google Scholar
Toaldo IM, Cruz FA, da Silva EL, Bordignon-Luiz MT. Acute consumption of organic and conventional tropical grape juices (Vitis labrusca L.) increases antioxidants in plasma and erythrocytes, but not glucose and uric acid levels, in healthy individuals. Nutr Res. 2016;36:808–17.
Article
CAS
PubMed
Google Scholar
Toscano LT, Silva AS, Toscano LT, Tavares RL, Biasoto ACT, de Camargo AC, da Silva CSO. Gonçalves MdCR, Shahidi F: Phenolics from purple grape juice increase serum antioxidant status and improve lipid profile and blood pressure in healthy adults under intense physical training. J Funct Foods. 2017;33:419–24.
Article
CAS
Google Scholar
Toscano LT, Tavares RL, Toscano LT, Silva CSO, AEMd A, ACT B, MdCR G, Silva AS. Potential ergogenic activity of grape juice in runners. Appl Physiol Nutr Metab. 2015;40:899–906.
Article
CAS
PubMed
Google Scholar
Turki K, Charradi K, Boukhalfa H, Belhaj M, Limam F, Aouani E. Grape seed powder improves renal failure of chronic kidney disease patients. EXCLI J. 2016;15:424.
PubMed
PubMed Central
Google Scholar
Yubero N, Sanz-Buenhombre M, Guadarrama A, Villanueva S, Carrion JM, Larrarte E, Moro C. LDL cholesterol-lowering effects of grape extract used as a dietary supplement on healthy volunteers. Int J Food Sci Nutr. 2013;64:400–6.
Article
CAS
PubMed
Google Scholar
Durak İ, Burak Cimen M, Büyükkogak S, Kaçpmaz M, Serdar Öztürk H. The effect of red wine on blood antioxidant potential. Curr Med Res Opin. 1999;15:208–13.
Article
CAS
PubMed
Google Scholar
Agte VV, Pathare P, Nilegaonkar S, Tupe R, Adesara K, Mali A, Padwal M, Melinkeri R. Effect of phytonutrient rich juice blends on antioxidant status and lipid profile in Young adults: a randomised trial. J Clin Diagnostic Res. 2018;12:6–10.
Díaz-Rubio ME, Pérez-Jiménez J, Martínez-Bartolomé MÁ, Álvarez I, Saura-Calixto F. Regular consumption of an antioxidant-rich juice improves oxidative status and causes metabolome changes in healthy adults. Plant Foods Hum Nutr. 2015;70:9–14.
Article
PubMed
CAS
Google Scholar
Novembrino C, Cighetti G, De Giuseppe R, Vigna L, de Liso F, Pellegatta M, Gregori D, Maiavacca R, Bamonti F. Effects of encapsulated fruit and vegetable juice powder concentrates on oxidative status in heavy smokers. J Am Coll Nutr. 2011;30:49–56.
Article
CAS
PubMed
Google Scholar
Spormann TM, Albert FW, Rath T, Dietrich H, Will F, Stockis J-P, Eisenbrand G, Janzowski C. Anthocyanin/polyphenolic–rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis. Cancer Epidemiology and Prevention. Biomarkers. 2008;17:3372–80.
CAS
Google Scholar
Urquiaga I, Troncoso D, Mackenna MJ, Urzúa C, Pérez D, Dicenta S, De la Cerda PM, Amigo L, Carreño JC, Echeverría G. The consumption of beef burgers prepared with wine grape pomace flour improves fasting glucose, plasma antioxidant levels, and oxidative damage markers in humans: a controlled trial. Nutrients. 2018;10:1388.
Article
PubMed Central
CAS
Google Scholar
Yuan L, Meng L, Ma W, Xiao Z, Zhu X, Feng JF, Yu H, Xiao R. Impact of apple and grape juice consumption on the antioxidant status in healthy subjects. Int J Food Sci Nutr. 2011;62:844–50.
Article
CAS
PubMed
Google Scholar
Sattarinezhad A, Roozbeh J, Yeganeh BS, Omrani G, Shams M. Resveratrol reduces albuminuria in diabetic nephropathy: a randomized double-blind placebo-controlled clinical trial. Diabetes Metab. 2019;45:53–9.
Article
CAS
PubMed
Google Scholar
Avellone G, Di Garbo V, Campisi D, De Simone R, Raneli G, Scaglione R, Licata G. Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis. Eur J Clin Nutr. 2006;60:41–7.
Article
CAS
PubMed
Google Scholar
Estruch R, Sacanella E, Mota F, Chiva-Blanch G, Antúnez E, Casals E, Deulofeu R, Rotilio D, Andres-Lacueva C, Lamuela-Raventos R. Moderate consumption of red wine, but not gin, decreases erythrocyte superoxide dismutase activity: a randomised cross-over trial. Nutr Metab Cardiovasc Dis. 2011;21:46–53.
Article
CAS
PubMed
Google Scholar
Lafay S, Jan C, Nardon K, Lemaire B, Ibarra A, Roller M, Houvenaeghel M, Juhel C, Cara L. Grape extract improves antioxidant status and physical performance in elite male athletes. J Sports Sci Med. 2009;8:468.
PubMed
PubMed Central
Google Scholar
Noguer M, Cerezo AB, Navarro ED, Garcia-Parrilla M. Intake of alcohol-free red wine modulates antioxidant enzyme activities in a human intervention study. Pharmacol Res. 2012;65:609–14.
Article
CAS
PubMed
Google Scholar
Torres A, Cachofeiro V, Millán J, Lahera V, Nieto M, Martín R, Bello E, Alvarez-Sala L. Red wine intake but not other alcoholic beverages increases total antioxidant capacity and improves pro-inflammatory profile after an oral fat diet in healthy volunteers. Revista Clinica Espanola. 2015;215:486–94.
Article
CAS
PubMed
Google Scholar
Mellen PB, Daniel KR, Brosnihan KB, Hansen KJ, Herrington DM. Effect of muscadine grape seed supplementation on vascular function in subjects with or at risk for cardiovascular disease: a randomized crossover trial. J Am Coll Nutr. 2010;29:469–75.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chuang C-C, McIntosh MK. Potential mechanisms by which polyphenol-rich grapes prevent obesity-mediated inflammation and metabolic diseases. Annu Rev Nutr. 2011;31:155–76.
Article
CAS
PubMed
Google Scholar
Woerdeman J, Van Poelgeest E, Ket J, Eringa E, Serné E, Smulders Y. Do grape polyphenols improve metabolic syndrome components? A systematic review. Eur J Clin Nutri. 2017;71:1381–92.
Article
CAS
Google Scholar
Feringa HH, Laskey DA, Dickson JE, Coleman CI. The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials. J Am Diet Assoc. 2011;111:1173–81.
Article
CAS
PubMed
Google Scholar
Vaisman N, Niv E. Daily consumption of red grape cell powder in a dietary dose improves cardiovascular parameters: a double blind, placebo-controlled, randomized study. Int J food Sci Nutri. 2015;66:342–9.
Article
CAS
Google Scholar
Kubyshkin A, Avidzba A, Borisyuk V, Stoyanov V, Fomochkina I, Ogai YA, Chernousova I, Zaitsev G, Guguchkina T, Markosov V. Polyphenols of red grapes in wine and concentrates for use in rehabilitation technologies. Agricultural Biol. 2017;52:622–30.
Google Scholar
Castilla P, Dávalos A, Teruel JL, Cerrato F, Fernández-Lucas M, Merino JL, Sánchez-Martín CC, Ortuño J, Lasunción MA. Comparative effects of dietary supplementation with red grape juice and vitamin E on production of superoxide by circulating neutrophil NADPH oxidase in hemodialysis patients. Am J Clin Nutr. 2008;87:1053–61.
Article
CAS
PubMed
Google Scholar
Castilla P, Echarri R, Dávalos A, Cerrato F, Ortega H, Teruel JL, Lucas MF, Gómez-Coronado D, Ortuño J, Lasunción MA. Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects. Am J Clin Nutr. 2006;84:252–62.
Article
CAS
PubMed
Google Scholar
Razavi S-M, Gholamin S, Eskandari A, Mohsenian N, Ghorbanihaghjo A, Delazar A, Rashtchizadeh N, Keshtkar-Jahromi M, Argani H. Red grape seed extract improves lipid profiles and decreases oxidized low-density lipoprotein in patients with mild hyperlipidemia. J Med Food. 2013;16:255–8.
Article
CAS
PubMed
Google Scholar
Bo S, Ciccone G, Castiglione A, Gambino R, De Michieli F, Villois P, Durazzo M, Cavallo-Perin P, Cassader M. Anti-inflammatory and antioxidant effects of resveratrol in healthy smokers a randomized, double-blind, placebo-controlled, cross-over trial. Curr Med Chem. 2013;20:1323–31.
Article
CAS
PubMed
Google Scholar
Park YK, Lee SH, Park E, Kim J-S, Kang M-H. Changes in antioxidant status, blood pressure, and lymphocyte DNA damage from grape juice supplementation. Ann New York Acad Sci. 2009;1171:385.
Article
CAS
Google Scholar
Bloomer R, Davis PG, Consitt L, Wideman L. Plasma protein carbonyl response to increasing exercise duration in aerobically trained men and women. Int J Sports Med. 2007;28:21–5.
Article
CAS
PubMed
Google Scholar
Goto C, Higashi Y, Kimura M, Noma K, Hara K, Nakagawa K, Kawamura M, Chayama K, Yoshizumi M, Nara I. Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress. Circulation. 2003;108:530–5.
Article
PubMed
Google Scholar
Smoliga JM, Colombo ES, Campen MJ. A healthier approach to clinical trials evaluating resveratrol for primary prevention of age-related diseases in healthy populations. Aging (Albany NY). 2013;5:495.
Article
CAS
Google Scholar
Joseph JA, Shukitt-Hale B, Casadesus G. Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr. 2005;81:313S–6S.
Article
CAS
PubMed
Google Scholar
Meyer AS, Yi O-S, Pearson DA, Waterhouse AL, Frankel EN. Inhibition of human low-density lipoprotein oxidation in relation to composition of phenolic antioxidants in grapes (Vitis vinifera). J Agric Food Chem. 1997;45:1638–43.
Article
CAS
Google Scholar
Sato M, Ramarathnam N, Suzuki Y, Ohkubo T, Takeuchi M, Ochi H. Varietal differences in the phenolic content and superoxide radical scavenging potential of wines from different sources. J Agric Food Chem. 1996;44:37–41.
Article
CAS
Google Scholar
Dohadwala MM, Vita JA. Grapes and cardiovascular disease. J Nutr. 2009;139:1788S–93S.
Article
CAS
PubMed
PubMed Central
Google Scholar
Folts JD. Potential health benefits from the flavonoids in grape products on vascular disease. In: Flavonoids in cell function: Springer; 2002. p. 95–111.
Chapter
Google Scholar
Reinisalo M, Kårlund A, Koskela A, Kaarniranta K, Karjalainen RO. Polyphenol stilbenes: molecular mechanisms of defence against oxidative stress and aging-related diseases. Oxidative Med Cell Longev. 2015;2015:1–24.
Eggler AL, Gay KA, Mesecar AD. Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2. Mol Nutr Food Res. 2008;52:S84–94.
PubMed
Google Scholar
Natella F, Belelli F, Gentili V, Ursini F, Scaccini C. Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. J Agric Food Chem. 2002;50:7720–5.
Article
CAS
PubMed
Google Scholar
Aviram M, Rosenblat M, Bisgaier CL, Newton RS, Primo-Parmo SL, La Du BN. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J Clin Invest. 1998;101:1581–90.
Article
CAS
PubMed
PubMed Central
Google Scholar
Williamson G, Manach C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr. 2005;81:243S–55S.
Article
CAS
PubMed
Google Scholar
Dani C, Oliboni LS, Vanderlinde R, Pra D, Dias JF, Yoneama ML, Bonatto D, Salvador M, Henriques JA. Antioxidant activity and phenolic and mineral content of rose grape juice. J Med Food. 2009;12:188–92.
Article
CAS
PubMed
Google Scholar
Chiva-Blanch G, Urpi-Sarda M, Ros E, Valderas-Martinez P, Casas R, Arranz S, Guillén M, Lamuela-Raventós RM, Llorach R, Andres-Lacueva C. Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: a randomized clinical trial. Clin Nutr. 2013;32:200–6.
Article
CAS
PubMed
Google Scholar
Das S, Vasisht S, Das N, Srivastava L, Dubey K, Watal G. Correlation between total antioxidant status and lipid peroxidation in hypercholesterolemia. Current Sci-Bangalore. 2000;78:486.
CAS
Google Scholar