Reply to: vitamin D supplementation and hemoglobin: dosing matters in prevention/treatment of anemia
Nutrition Journal volume 20, Article number: 33 (2021)
We thank Professor Lena Napolitano for her insightful comments on our study. One of the concerns raised was regarding the correct interpretation of several words, such as the “length of intervention” mentioned in table 1; therefore, we have changed the duration of studies to intervention in order to include all of the items used in this manuscript. Furthermore, regarding two of the studies, namely by Smith et al., We used the publication years mentioned in the articles themselves, which are different from their citation years [1, 2].
In our subgroup analysis, we divided the studies based on the general health conditions. However, per your recommendations, we also performed the analysis separately in anemic and non-anemic patients. As shown in Fig. 1, the effect of vitamin D was not significant in any of these groups.
Smith EM, Alvarez JA, Kearns MD, Hao L, Sloan JH, Konrad RJ, et al. High-dose vitamin D3 reduces circulating hepcidin concentrations: a pilot, randomized, double-blind, placebo-controlled trial in healthy adults. Clin Nutr. 2017;36(4):980–5.
Smith EM, Jones JL, Han JE, Alvarez JA, Sloan JH, Konrad RJ, et al. High-dose vitamin D3 administration is associated with increases in hemoglobin concentrations in mechanically ventilated critically ill adults: a pilot double-blind, randomized, placebo-controlled trial. J Parenter Enter Nutr. 2018;42(1):87–94.
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Arabi, S.M., Ranjbar, G., Bahrami, L.S. et al. Reply to: vitamin D supplementation and hemoglobin: dosing matters in prevention/treatment of anemia. Nutr J 20, 33 (2021). https://doi.org/10.1186/s12937-021-00683-8