O’Connor DMA, Laird EJ, Carey D, O’Halloran AM, Clarke R, Kenny RA, et al. Plasma concentrations of vitamin B12 and folate and global cognitive function in an older population: cross-sectional findings from the Irish longitudinal study on ageing (TILDA). Br J Nutr. 2020:1–25. https://doi.org/10.1017/S0007114520001427 [Epub ahead of print].
Doets EL, Ueland PM, Tell GS, Vollset SE, Nygård OK, Van't Veer P, et al. Interactions between plasma concentrations of folate and markers of vitamin B (12) status with cognitive performance in elderly people not exposed to folic acid fortification: the Hordaland health study. Br J Nutr. 2014;111(6):1085–95. https://doi.org/10.1017/S000711451300336X.
Article
CAS
PubMed
Google Scholar
Triantafyllou NI, Nikolaou C, Boufidou F, Angelopoulos E, Rentzos M, Kararizou E, et al. Folate and vitamin B12 levels in levodopa-treated Parkinson's disease patients: their relationship to clinical manifestations, mood and cognition. Parkinsonism Relat Disord. 2008;14(4):321–5.
Article
Google Scholar
Ates Bulut E, Soysal P, Aydin AE, Dokuzlar O, Kocyigit SE, Isik AT. Vitamin B12 deficiency might be related to sarcopenia in older adults. Exp Gerontol. 2017;95:136–40. https://doi.org/10.1016/j.exger.2017.05.017.
Article
CAS
PubMed
Google Scholar
Matteini AM, Walston JD, Fallin MD, Bandeen-Roche K, Kao WH, Semba RD, et al. Markers of B-vitamin deficiency and frailty in older women. J Nutr Health Aging. 2008;12(5):303–8. https://doi.org/10.1007/BF02982659.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sanchez H, Hossain MB, Lera L, Hirsch S, Albala C, Uauy R, et al. High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans. Clin Epigenetics. 2017;9:74. https://doi.org/10.1186/s13148-017-0374-y.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mc Auley MT, Mooney KM, Salcedo-Sora JE. Computational modelling folate metabolism and DNA methylation: implications for understanding health and ageing. Brief Bioinform. 2018;19(2):303–17. https://doi.org/10.1093/bib/bbw116.
Article
CAS
PubMed
Google Scholar
Zhang W, Song M, Qu J, Liu GH. Epigenetic modifications in cardiovascular aging and diseases. Circ Res. 2018;123(7):773–86. https://doi.org/10.1161/CIRCRESAHA.118.312497.
Article
CAS
PubMed
Google Scholar
Mandaviya PR, Joehanes R, Brody J, Castillo-Fernandez JE, Dekkers KF, Do AN, et al. Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals. Am J Clin Nutr. 2019;110(2):437–50. https://doi.org/10.1093/ajcn/nqz031.
Article
PubMed
Google Scholar
Shane B, Stokstad EL. Vitamin B12-folate interrelationships. Annu Rev Nutr. 1985;5:115–41. https://doi.org/10.1146/annurev.nu.05.070185.000555.
Article
CAS
PubMed
Google Scholar
EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific opinion on dietary reference values for folate. EFSA J. 2014;12(11):3893. https://doi.org/10.2903/j.efsa.2014.3893.
Article
CAS
Google Scholar
Brosnan JT, Brosnan ME. Creatine: endogenous metabolite, dietary, and therapeutic supplement. Annu Rev Nutr. 2007;27:241–61. https://doi.org/10.1146/annurev.nutr.27.061406.093621.
Article
CAS
PubMed
Google Scholar
Mudd SH, Brosnan JT, Brosnan ME, Jacobs RL, Stabler SP, Allen RH, et al. Methyl balance and transmethylation fluxes in humans. Am J Clin Nutr. 2007;85(1):19–25. https://doi.org/10.1093/ajcn/85.1.19.
Article
CAS
PubMed
Google Scholar
Paul L, Selhub J. Interaction between excess folate and low vitamin B12 status. Mol Asp Med. 2017;53:43–7. https://doi.org/10.1016/j.mam.2016.11.004.
Article
CAS
Google Scholar
Hughes CF, Ward M, Hoey L, McNulty H. Vitamin B12 and ageing: current issues and interaction with folate. Ann Clin Biochem. 2013;50(Pt 4):315–29. https://doi.org/10.1177/0004563212473279.
Article
CAS
PubMed
Google Scholar
Wahlin A, Bäckman L, Hultdin J, Adolfsson R, Nilsson LG. Reference values for serum levels of vitamin B12 and folic acid in a population-based sample of adults between 35 and 80 years of age. Public Health Nutr. 2002;5(3):505–11. https://doi.org/10.1079/PHNPHN200167.
Article
PubMed
Google Scholar
Refsum H, Johnston C, Guttormsen AB, Nexo E. Holotranscobalamin and total transcobalamin in human plasma: determination, determinants, and reference values in healthy adults. Clin Chem. 2006;52(1):129–37. https://doi.org/10.1373/clinchem.2005.054619.
Article
CAS
PubMed
Google Scholar
Andrew T, Gill R, Gillham-Nasenya I, Ahmadi KR. Unravelling the basis of variability in cobalamin levels in the general population. Br J Nutr. 2013;110(9):1672–9. https://doi.org/10.1017/S0007114513000974.
Article
CAS
PubMed
Google Scholar
De Bruyn E, Gulbis B, Cotton F. Serum and red blood cell folate testing for folate deficiency: new features? Eur J Haematol. 2014;92(4):354–9. https://doi.org/10.1111/ejh.12237.
Article
CAS
PubMed
Google Scholar
Gaskins AJ, Chiu YH, Williams PL, Ford JB, Toth TL, Hauser R. Chavarro JE; EARTH study team. Association between serum folate and vitamin B-12 and outcomes of assisted reproductive technologies. Am J Clin Nutr. 2015;102(4):943–50. https://doi.org/10.3945/ajcn.115.112185.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jungert A, Neuhäuser-Berthold M. Predictors of serum cobalamin and its association with homocysteine in community-dwelling older adults. Eur J Clin Nutr. 2019;73(9):1307–15. https://doi.org/10.1038/s41430-018-0367-8.
Article
CAS
PubMed
Google Scholar
Allen LH. How common is vitamin B-12 deficiency? Am J Clin Nutr. 2009;89(2):693S–6S. https://doi.org/10.3945/ajcn.2008.26947A.
Article
CAS
PubMed
Google Scholar
Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev. 2000;80(3):1107–213. https://doi.org/10.1152/physrev.2000.80.3.1107.
Article
CAS
PubMed
Google Scholar
Jungert A, Neuhäuser-Berthold M. The lower vitamin C plasma concentrations in elderly men compared with elderly women can partly be attributed to a volumetric dilution effect due to differences in fat-free mass. Br J Nutr. 2015;113(5):859–64. https://doi.org/10.1017/S0007114515000240.
Article
CAS
PubMed
Google Scholar
Lührmann PM, Herbert BM, Gaster C, Neuhäuser-Berthold M. Validation of a self-administered 3-day estimated dietary record for use in the elderly. Eur J Nutr. 1999;38(5):235–40.
Article
Google Scholar
Seelig HP, Wüst H. Die Kreatininbestimmung mit der Jaffé Reaktion. Ärztl Lab. 1969;15:34–9.
CAS
Google Scholar
EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2015. Scientific opinion on dietary reference values for cobalamin (vitamin B12). EFSA J. 2015;13(7):4150. https://doi.org/10.2903/j.efsa.2015.4150.
Article
CAS
Google Scholar
Ströhle A, Richter M, González-Gross M, Neuhäuser-Berthold M, Wagner KH, Leschik-Bonnet E, et al. German nutrition society (DGE). The revised D-A-CH-reference values for the intake of vitamin B12: prevention of deficiency and beyond. Mol Nutr Food Res. 2019;63(6):e1801178. https://doi.org/10.1002/mnfr.201801178.
Article
CAS
PubMed
Google Scholar
Krawinkel MB, Strohm D, Weissenborn A, Watzl B, Eichholzer M, Bärlocher K, et al. Revised D-A-CH intake recommendations for folate: how much is needed? Eur J Clin Nutr. 2014;68(6):719–23. https://doi.org/10.1038/ejcn.2014.45.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pinheiro J, Bates D, DebRoy S, Sarkar D, R Core Team. Nlme: linear and nonlinear mixed effects models. R package version 3.1–145; 2019.
Google Scholar
Hothorn T, Bretz F, Westfall P. Simultaneous inference in general parametric models. Version 1.4–13; 2020. https://cran.r-project.org/web/packages/multcomp/multcomp.pdf. Accessed 10 May 2020.
Google Scholar
Max Rubner-Institute (MRI). Nationale Verzehrsstudie: Ergebnisbericht Teil 2. Bundesministerium für Ernährung, Landwirtschaft und Verbraucherschutz; 2008. https://www.bmel.de/SharedDocs/Downloads/Ernaehrung/NVS_ErgebnisberichtTeil2.pdf?__blob=publicationFile [German]. Accessed 15 Aug 2019.
Google Scholar
Pfeiffer CM, Sternberg MR, Fazili Z, Lacher DA, Zhang M, Johnson CL, et al. Folate status and concentrations of serum folate forms in the US population: National Health and Nutrition Examination Survey 2011-2. Br J Nutr. 2015;113(12):1965–77. https://doi.org/10.1017/S0007114515001142.
Rycyna KJ, Bacich DJ, O'Keefe DS. Divergence between dietary folate intake and concentrations in the serum and red blood cells of aging males in the United States. Clin Nutr. 2016;35(4):928–34. https://doi.org/10.1016/j.clnu.2015.07.002.
Article
CAS
PubMed
Google Scholar
Bailey RL, Fulgoni VL, Taylor CL, Pfeiffer CM, Thuppal SV, McCabe GP, et al. Correspondence of folate dietary intake and biomarker data. Am J Clin Nutr. 2017;105(6):1336–43. https://doi.org/10.3945/ajcn.116.148775.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chanarin I. The megaloblastic anaemias. Oxford: Blackwell Scientific Publications; 1969.
Google Scholar
Bor MV, von Castel-Roberts KM, Kauwell GP, Stabler SP, Allen RH, Maneval DR, et al. Daily intake of 4 to 7 microg dietary vitamin B-12 is associated with steady concentrations of vitamin B-12-related biomarkers in a healthy young population. Am J Clin Nutr. 2010;91:571–7. https://doi.org/10.3945/ajcn.2009.28082.
Article
CAS
PubMed
Google Scholar
Andrès E, Loukili NH, Noel E, Kaltenbach G, Abdelgheni MB, Perrin AE, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. 2004;171(3):251–9. https://doi.org/10.1503/cmaj.1031155.
Article
PubMed
PubMed Central
Google Scholar
Andrès E, Serraj K, Zhu J, Vermorken AJ. The pathophysiology of elevated vitamin B12 in clinical practice. QJM. 2013;106(6):505–15. https://doi.org/10.1093/qjmed/hct051.
Article
CAS
PubMed
Google Scholar
Wang H, Li L, Qin LL, Song Y, Vidal-Alaball J, Liu TH. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018;3:CD004655. https://doi.org/10.1002/14651858.CD004655.pub3.
Article
PubMed
Google Scholar
Risch M, Meier DW, Sakem B, Medina Escobar P, Risch C, Nydegger U, et al. Vitamin B12 and folate levels in healthy Swiss senior citizens: a prospective study evaluating reference intervals and decision limits. BMC Geriatr. 2015;15:82. https://doi.org/10.1186/s12877-015-0060-x.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tosato M, Marzetti E, Cesari M, Savera G, Miller RR, Bernabei R, et al. Measurement of muscle mass in sarcopenia: from imaging to biochemical markers. Aging Clin Exp Res. 2017;29(1):19–27. https://doi.org/10.1007/s40520-016-0717-0.
Article
PubMed
Google Scholar
Gamble MV, Ahsan H, Liu X, Factor-Litvak P, Ilievski V, Slavkovich V, et al. Folate and cobalamin deficiencies and hyperhomocysteinemia in Bangladesh. Am J Clin Nutr. 2005;81(6):1372–7. https://doi.org/10.1093/ajcn/81.6.1372.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dinning JS, Day PL. Creatinuria during recovery from aminopterin-induced folic acid deficiency in the monkey. J Biol Chem. 1949;181(2):897–903.
CAS
PubMed
Google Scholar
Fatterpaker P, Marfatia U, Sreenivasan A. Influence of folic acid and vitamin B12 on formation of creatine in vitro and in vivo. Nature. 1951;167(4261):1067–8. https://doi.org/10.1038/1671067a0.
Article
CAS
PubMed
Google Scholar
Turner CE, Byblow WD, Gant N. Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation. J Neurosci. 2015;35(4):1773–80. https://doi.org/10.1523/JNEUROSCI.3113-14.2015.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gouspillou G, Bourdel-Marchasson I, Rouland R, Calmettes G, Biran M, Deschodt-Arsac V, et al. Mitochondrial energetics is impaired in vivo in aged skeletal muscle. Aging Cell. 2014;13(1):39–48. https://doi.org/10.1111/acel.12147.
Article
CAS
PubMed
Google Scholar
Varadhan R, Russ DW, Gabr RE, Huang J, Kalyani RR, Xue QL, et al. Relationship of physical frailty to phosphocreatine recovery in muscle after mild exercise stress in the oldest-old women. J Frailty Aging. 2019;8(4):162–8. https://doi.org/10.14283/jfa.2019.21.
Article
CAS
PubMed
Google Scholar
Reutzel M, Grewal R, Dilberger B, Silaidos C, Joppe A, Eckert GP. Cerebral mitochondrial function and cognitive performance during aging: a longitudinal study in NMRI mice. Oxid Med Cell Longev. 2020;2020:4060769. https://doi.org/10.1155/2020/4060769.
Clarke R, Grimley Evans J, Schneede J, Nexo E, Bates C, Fletcher A, et al. Vitamin B12 and folate deficiency in later life. Age Ageing. 2004;33(1):34–41. https://doi.org/10.1093/ageing/afg109.
Article
PubMed
Google Scholar
Pfeiffer CM, Sternberg MR, Schleicher RL, Rybak ME. Dietary supplement use and smoking are important correlates of biomarkers of water-soluble vitamin status after adjusting for sociodemographic and lifestyle variables in a representative sample of U.S. adults. J Nutr. 2013;143(6):957S–65S. https://doi.org/10.3945/jn.112.173021.
Article
CAS
PubMed
PubMed Central
Google Scholar
Grimes DA, Schulz KF. Descriptive studies: what they can and cannot do. Lancet. 2002;359(9301):145–9. https://doi.org/10.1016/S0140-6736(02)07373-7.
Article
PubMed
Google Scholar
Ulvik A, Ebbing M, Hustad S, Midttun Ø, Nygård O, Vollset SE, et al. Long- and short-term effects of tobacco smoking on circulating concentrations of B vitamins. Clin Chem. 2010;56(5):755–63. https://doi.org/10.1373/clinchem.2009.137513.
Article
CAS
PubMed
Google Scholar
Mahabir S, Ettinger S, Johnson L, Baer DJ, Clevidence BA, Hartman TJ, et al. Measures of adiposity and body fat distribution in relation to serum folate levels in postmenopausal women in a feeding study. Eur J Clin Nutr. 2008;62(5):644–50. https://doi.org/10.1038/sj.ejcn.1602771.
Article
CAS
PubMed
Google Scholar
Soysal P, Smith L, Capar E, Kalan U, Arik F, Isik AT. Vitamin B12 and folate deficiencies are not associated with nutritional or weight status in older adults. Exp Gerontol. 2019;116:1–6. https://doi.org/10.1016/j.exger.2018.12.007.
Article
CAS
PubMed
Google Scholar
Hvas AM, Nexo E. Holotranscobalamin – a first choice assay for diagnosing early vitamin B deficiency? J Intern Med. 2005;257:289–98. https://doi.org/10.1111/j.1365-2796.2004.01437.x.
Article
CAS
PubMed
Google Scholar
Farrell CJ, Kirsch SH, Herrmann M. Red cell or serum folate: what to do in clinical practice? Clin Chem Lab Med. 2013;51(3):555–69. https://doi.org/10.1515/cclm-2012-0639.
Article
CAS
PubMed
Google Scholar