Skip to main content

Advertisement

Higher dietary magnesium intake is associated with lower body mass index, waist circumference and serum glucose in Mexican adults

Nutrition Journalvolume 17, Article number: 114 (2018) | Download Citation

Abstract

Background

Obesity and diabetes mellitus (DM) are public health concerns in Mexico of top-level priority due to their high prevalence and their growth rate in recent decades. The accumulation of adipose tissue leads to an unbalanced release of pro-oxidant factors, which causes cellular damage and favors the development of comorbidities. Recent evidence suggests that oxidative stress also promotes the accumulation of adipose tissue and the development of insulin resistance. The objective of this study is to evaluate the association between usual intake of antioxidant nutrients, specifically vitamins A, C, E and magnesium with body mass index (BMI), waist circumference (WC) and serum glucose concentrations in a representative sample of Mexican adults.

Methodology

We analyzed data on diet, BMI, WC and serum glucose from the Mexican National Health and Nutrition Survey 2012. Analysis included 20- to 65-year-old adults without a known diagnosis of DM (n = 1573). Dietary information was obtained using the five-step multiple-pass method developed by the United States Department of Agriculture and adapted to the Mexican context. Nutrient usual intake distributions were estimated using the Iowa State University method, through the “Software for Intake Distribution Estimation” (PC-Side) v.1.02. Associations were analyzed using multivariate regression models.

Results

Higher dietary magnesium intake was associated with lower markers of adiposity, so that an increase in 10 mg per 1000 kcal/day of magnesium was associated with an average decrease in BMI of 0.72% (95% CI: -1.36, − 0.08) and 0.49 cm (95% CI: -0.92, − 0.07) of WC. Additionally, in women with normal glucose concentrations, an increase in magnesium intake was associated with an average decrease in serum glucose by 0.59% (95% CI: -1.08, − 0.09).

Conclusion

The results suggest that magnesium intake is associated with lower BMI, WC and serum glucose in Mexican population. However, more studies are required to elucidate the nature of this association.

Open Peer Review reports

Background

Obesity and its comorbidities, including diabetes mellitus (DM), are public health concerns worldwide. In the last decades, they received top-level priority due to their high prevalence and speed of growth [1]. In Mexico, in the year 2016, the estimated prevalence of overweight and obesity in adults was 72.5%, showing a marked increase from a prevalence of 56% in the year 2000 [2, 3]. Furthermore, unpublished data estimated that in 2012, 22% of the Mexican adult population were glucose intolerant, and 13% of women and 14% of men had DM [S. Villalpando, personal communication, January 2018].

The accumulation of adipose tissue favors the presence of systemic oxidative stress (OS), which can be a trigger for the development of alterations in glucose metabolism [4,5,6,7,8]. However, recent evidence suggests that this mechanism may also occur inversely, where OS can favor the accumulation of adipose tissue. It has been observed that treatment with antioxidant nutrients prevents in vitro formation of adipocytes from pre-adipocytes [9], and in animal models prevents the excessive accumulation of adipose tissue associated with diet [10, 11]. In addition, OS causes a disruption in the production of cytokines [4], which together with a high production of reactive oxygen species (ROS), decreases glucose uptake in muscular and adipose tissue [6, 7] and decreases insulin secretion in pancreatic beta cells [8].

Antioxidant nutrients mitigate the damage caused by OS through different mechanisms. Vitamin A inhibits lipid peroxidation by trapping free radicals in cell membranes [12], regulates leptin mRNA in adipose tissue and also exerts an inhibitory effect on adipogenesis [13]. Vitamin C is a redox catalyst that neutralizes ROS [14], while vitamin E in its alfa-tocopherol form reacts with ROS produced in lipid peroxidation, protecting the cell membranes [15, 16]. Magnesium is involved in energy metabolism since intracellular adenosine triphosphate (ATP) is in the form of ATP-Mg [17] and it is also a cofactor of several antioxidant enzymes, including superoxide dismutase (SOD), one of the most important antioxidant enzymes [17, 18].

According to the results from the 2012 Mexican National Health and Nutrition Survey (ENSANUT) there is a high prevalence of inadequate intake of several nutrients with antioxidant function including vitamin A, C, E and magnesium, in the adult Mexican population [19, 20]. However, this prevalence has not been characterized by body weight status or serum glucose concentrations in this population. Additionally, since previous studies have shown a relationship between antioxidant nutrients intake, adiposity and insulin resistance [10, 21,22,23,24,25,26], the objective of this study is to evaluate the association between dietary intake of vitamins A, C, E, magnesium, and body mass index (BMI), waist circumference (WC), and serum glucose concentrations in a representative sample of 20- to 65-year-old Mexican adults.

Methods

Study design

The ENSANUT 2012 is a population-based multistage probabilistic survey representative of the Mexican population at a national, regional and state level, for urban and rural areas. The main objective of the survey was to quantify the distribution of health and nutrition parameters among the Mexican population as well as their determinants. Information from 96,031 individuals belonging to 50,528 randomly selected households was collected by face-to-face interviews carried out between October 2011 and May 2012. The complete methodology has been previously described elsewhere [27].

Participants

For this study, we considered 20- to 65-year-old nonpregnant nonlactating participants with diet, serum glucose, and anthropometric information (n = 1739). Pregnant or lactating women were not included because their nutritional needs and body composition are different from the rest of the women. We excluded from the analysis subjects with low weight (n = 14), defined as a BMI < 18.5 kg/m2, or with known diagnosis of DM (n = 152). The final study sample included 1573 participants. Reporting was conducted in accordance with the STROBE statement [see Additional file 1].

Diet

Detailed diet information was obtained with a 24-h dietary recall applied by trained personnel to a randomly selected subsample of ∼11% (n = 10,886) of the total respondents of the ENSANUT 2012 using the five-step multiple-pass method developed by the United States Department of Agriculture (USDA) [28] and adapted to the Mexican context [29]. A second 24-h recall was applied to a ∼ 9% (n = 981) random subsample. For this study, 9.3% (n = 162) of the 1573 participants answered a second 24-h recall. Interviews were performed between Monday and Sunday, and repeated measurements were obtained on non-consecutive days with an average of 2.4 (± 1.2) days between each other. The detailed methodology for the collection of dietary information is described elsewhere [29].

Intake of vitamins A, C, E and magnesium were estimated using the food composition table compiled by the National Institute of Public Health (INSP) of Mexico [30]. Nutrient intake values higher than 1.5 times the 99th percentile were considered excessive, for vitamin A (n = 8), vitamin C (n = 9), vitamin E (n = 4), and magnesium (n = 3), and were replaced with random values between the 95th percentile and 1.5 times de 99th percentile of a uniform distribution.

Anthropometric measurements

Information on weight, height and waist circumference measurements were obtained by trained and standardized personnel using conventional and internationally accepted protocols [31, 32]. Height values between 1.3 and 2.0 m, and BMI values below 58 kg/m2 were considered as valid data. All observations in the eligible sample were valid data. BMI categorization was based on the criterion proposed by the World Health Organization (WHO) [33]. The WC cut-off points used are the ones proposed by the International Diabetes Federation (IDF) (94 cm in men and 80 cm in women) [34].

Serum glucose

Serum glucose concentrations were analyzed in a sample of venous blood drawn from the antecubital vein and obtained after a minimum 8-h fast. It was collected in tubes without anticoagulant and was centrifuged in situ. Samples were stored in cryovials, placed in liquid nitrogen and stored at − 70 °C until assay. Measurements were performed at the laboratory of the Center for Nutrition and Health Research, INSP using an automatized glucose oxidase method performed in an Abbot ARCHITECT Analyzer.

Categorization was performed using the cut-off points proposed by the American Diabetes Association (ADA), which establish that concentrations between 40 and < 100 mg/dL are normal, 100 to < 126 mg/dL indicate glucose intolerance, and ≥ 126 mg/dL indicate DM [35]. To improve precision on the estimates for the prevalence of inadequate intake of nutrients, we combined categories of glucose intolerance and DM into one category of impaired glucose intolerance (serum glucose ≥100 mg/dL).

Physical activity

Physical activity was measured using the validated short form of the International Physical Activity Questionnaire (IPAQ-SF), which includes 9 items that collect information about frequency, duration and intensity of physical activity [36, 37]. An individual estimate of minutes per week of moderate physical activity was obtained adding the reported time spent doing moderate activity and two times the reported time doing vigorous activity. Based on the WHO recommendations for physical activity [38], participants were categorized as active (≥ 300 min per week), moderately active (150 to < 300), and inactive (< 150 min per week).

Statistical analysis

Nutrient usual intake distributions were estimated using the Iowa State University (ISU) method, through the “Software for Intake Distribution Estimation” (PC-Side) v.1.02. This method eliminates the effect of day-to-day variability in intake of each person, which results in a more accurate estimate of the prevalence of nutrient inadequacy. Intakes below the estimated average requirement (EAR) [39, 40] established by the Institute of Medicine of the United States [41,42,43] were considered to be inadequate.

Differences in prevalence of inadequate intake of nutrients between men and women and between groups defined by BMI, WC and serum glucose were analyzed performing Ζ-tests. Null hypotheses were rejected at an α level of 0.05 and Bonferroni corrections for multiple comparisons were applied for BMI groups.

The association between usual nutrient intake and adiposity was evaluated using multivariate multiple regression models, with BMI and WC as outcome variables, and adjusted for sex, age, physical activity and energy intake (kcal/day). The association between nutrient intake and serum glucose was evaluated using multiple regression and adjusted for sex, age, energy intake and BMI. Since BMI and serum glucose did not follow a normal distribution they were transformed to a logarithmic scale. The method used to adjust for energy intake was a multivariate model of nutrient density [44], which considers nutrient density and total energy intake as predictors. Nutrient density is defined as units of the nutrient per kcal of total energy intake.

Nutrient and energy intake for each person were adjusted by measurement error using the ISU method to obtain the best linear unbiased predictor (BLUP) of each person’s intake using PC-Side. Nutrient density was estimated from the ratio of the adjusted values of nutrient intake to energy intake and then multiplied by 100 to improve interpretability. These estimates as well as the BLUPs for energy intake were used in the regression models in place of the unobservable usual intakes.

The descriptive statistics of the study sample and the regression models to evaluate association were fitted using the Data Analysis and Statistical Software STATA v. 13.0. For the multivariate regression and all analysis using PC-Side we considered the sampling weight of each individual. For the descriptive statistics and the multiple regression analysis we considered the sampling weight, sampling strata and primary sample unit to adjust for the complex survey design of the ENSANUT.

Results

Characteristics of the study population are shown in Table 1. Our study sample included 1573 subjects, 46% male and 54% female, who together represent more than 37.5 million Mexican adults between the ages of 20 to 65 years. The observed prevalence of overweight was 39% while obesity was 30%, the latter being higher in women (38%) than in men (21%). Serum glucose concentrations compatible with alterations in glucose metabolism were observed in 28% of individuals (24% with glucose intolerance and 4% with DM).

Table 1 Anthropometric characteristics and serum glucose concentrations of 20- to 65-year-old Mexican adultsa
Full size table

Nutrient intake information from the total sample (consumers and non-consumers) was used to obtain results. The observed prevalence of inadequate intake of nutrients with antioxidant function was 56% for vitamin A, 29% for vitamin C, 94% for vitamin E and 16% for magnesium (Fig. 1). We did not observe any significant difference between men and women. The mean and percentiles of the estimated usual intake of each nutrient in men and women are presented in an additional table [see Additional file 2].

Fig. 1
figure1

Prevalence of inadequate intake of antioxidant nutrients in Mexican adults by serum glucose concentrations1. 1Analysis include 20- to 65-year-old adults. Data are from the Mexican National Health and Nutrition Survey 2012. Normal: 40 to < 100 mg/dL, glucose intolerance: 100 to < 126 mg/dL, diabetes mellitus: ≥126 mg/dL

Full size image

There were no significant differences in the prevalence of inadequate intake between strata of BMI, WC, and serum glucose for any of the analyzed nutrients (Table 2). However, we did observe that the prevalence of inadequate intake of vitamins A and C tended to be lower among persons with higher BMI; in the case of magnesium, the association between BMI and intake appeared to be negative (Table 2).

Table 2 Prevalence of inadequate intake of antioxidant nutrients in 20- to 65-year-old Mexican adultsa
Full size table

A negative association was observed between the intake of magnesium and markers of adiposity, so that an increase of 10 mg per 1000 kcal/day of magnesium was associated with an average decrease in BMI of 0.72% (95% CI: -1.36, − 0.08) and 0.49 cm (95% CI: -0.92, − 0.07) of WC, adjusting by sex, age and energy intake (Table 3). Additionally, an increase in magnesium intake was also associated with an average decrease in serum glucose concentrations of 0.38% (95% CI: -0.74, − 0.02) only in individuals with normal glucose concentrations; when stratifying by sex, this association was only statistically significant in women (− 0.59, 95% CI: -1.08, − 0.09). There were no statistically significant associations between the intake of vitamins A, C, E, and BMI, WC, and serum glucose concentrations.

Table 3 Association between the intake of antioxidant nutrients, BMI, WC and glucose concentrations in Mexican adultsa
Full size table

Discussion

This study analyzed the association between the dietary intake of nutrients with antioxidant function and markers of adiposity and serum glucose concentrations in Mexican adults 20 to 65 years of age. Increased magnesium intake was associated with lower BMI and lower WC. Additionally, increased magnesium intake was associated with lower serum glucose concentrations in individuals with normal glucose. To the best of our knowledge, this is the first study to describe the prevalence of inadequate intake of nutrients with antioxidant function by BMI, WC and serum glucose categories and to evaluate the association between its intake and markers of adiposity and glucose metabolism in this population.

In line with previous reports in Mexican population [45], the prevalence of abdominal obesity in our sample was 65%, being particularly high in women (83%). Mexico has one of the highest reported prevalence of abdominal obesity in adults compared to other countries, such as the United States with 56% (46% in men and 65% in women) [46], Brazil with 30% (20% in men and 38% in women) [47], and China with 37% (28% in men and 46% in women) [48]. In Mexican women, this prevalence has risen from 83% in 2012 [45], to 88% in 2016 [2]. This results highlight the magnitude of the problem of obesity as a public health concern in Mexico.

We did not find significant differences in the prevalence of inadequate intake of nutrients among strata of BMI or WC. These results are in line with the findings of a study involving 580 Mexican women from rural communities, where it was observed that, despite the fact that overweight and obese women reported higher energy intake compared to normal weight women, their intake of vitamins A, C and E did not differ significantly between them [49]. In contrast, a cross-sectional study of 18,177 American adults reported a higher prevalence of inadequate intake of several nutrients, including vitamins A, C, E and magnesium, in obese and overweight adults compared to non-obese [50]. This contrast could be explained because in this study we did not take into account the intake of dietary supplements, hence, total nutrient intake may be underestimated, particularly in normal weight individuals since supplement users are more likely to also have a healthier diet [51]. However, the discrepancies could also be explained by a lack of statistical power in this study sufficient to detect significant differences due to a smaller sample size or a greater variance in the usual intake distribution for the Mexican adults.

Consistent with our findings, other studies have also reported an inverse association between magnesium intake and markers of adiposity. A prospective study following 4637 young American adults found an inverse association between magnesium intake and WC [52]. Additionally, a cross-sectional study involving 11,686 American women found an inverse association between magnesium intake and BMI [53]. However, clinical studies evaluating the effect of magnesium supplementation on the accumulation of adipose tissue are still lacking. In animal models, it has been observed that magnesium supplementation prevents the accumulation of adipose tissue associated with diet [22]. The mechanism that explains this association is not yet fully understood. While one of the functions of magnesium is its antioxidant effect through enzymatic mechanisms, the role of OS in the development of obesity is still unclear.

Furthermore, several studies have reported that a lower magnesium intake is associated with an increased risk of insulin resistance [23, 52,53,54]. A prospective study that followed more than fifty thousand men and women from the United States over a period of 12–18 years found an inverse association between magnesium intake and the risk of developing DM [23]. A recent review identified seven randomized controlled studies (conducted between 1989 and 2014) that evaluated the effect of magnesium supplementation on fasting plasma glucose in prediabetic patients [55]: five studies reported a decrease in fasting plasma glucose after supplementation, while two studies reported no changes. In this study, the association between magnesium intake and serum glucose was only observed in women with normal glucose concentrations. An explanation as to why this association was not observed in glucose intolerants and diabetics could be that in DM, renal excretion of magnesium is increased [56], therefore diabetics may need a higher intake of magnesium to achieve the same concentrations as non-diabetics. The discrepant results between men and women are similar to the findings from a cohort of Japanese adults, in which during a follow-up of 10 years, a higher intake of magnesium was associated with a significantly reduced risk of DM only in women [57]. While the explanation is still not clear, there is evidence that women tend to have lower blood magnesium concentrations than men [58, 59], and thus would be more likely to be deficient and present adverse consequences, including a disrupted glucose metabolism. Additionally, the metabolic pathways involved in the association between magnesium and glucose metabolism may be different between men and women and might be attributed, at least in part, to differences in body composition, such as muscle mass.

This study has several strengths. The data are representative of the Mexican population 20 to 65 years of age. Diet was assessed using the five-step multiple-pass 24-h recall, which more accurately quantifies nutrient intake compared to other dietary assessment instruments [60]. Finally, we used cutting edge statistical methods to estimate usual intake of nutrients, allowing a better estimation of the prevalence of inadequate intake in the groups we considered, by adjusting the distribution of observed intake for within-person variability. However, the standard errors of the quantile estimates obtained using the ISU methodology were approximated using Taylor linearization which only considered the weighting of each individual on the survey and did not consider the strata and the primary sample unit to adjust for the complex survey design of the ENSANUT.

As is the case with any study that relies on self-reported food intake, one limitation is the potential reporting bias that exists with any instrument used to assess diet. It is well known that obese people have a tendency to underreport energy [61], but it is not well understood whether this underreporting is uniform across all dietary components [62, 63]. Since nutrient intake depends on the type of food consumed and not only on the amount of energy consumed, it is still unknown how under-reporting affects the report of specific nutrients. In addition, since this is an observational cross-sectional study, it is not possible to establish causality, for which longitudinal randomized trials are required to confirm these results.

Methods to estimate usual intake distributions rely heavily on the proportion of the variance in intake that is attributable to within-person variability. Most nationwide food consumption surveys (including ENSANUT) collect a second recall on a sub-sample of persons, which affects the precision of the within-person estimates. In our case, the estimated within-person variance in magnesium and vitamin A intake in males was implausibly high, and this had an effect on the accuracy in the prevalence of inadequate intake in these groups. However, a separate analysis using nutrient intake only from the first 24-h recall showed that the direction of the association was maintained and the effect size was attenuated but still significant [see Additional file 3].

Understanding the effect of the intake of a specific nutrient on some health outcome has important biological limitations because diet is a complex entity and there is high correlation and interaction between different nutrients or conditions that can affect their bioavailability. However, considering these limitations, it is striking to observe a strong association between magnesium intake and BMI, WC, and serum glucose concentrations.

On the other hand, we did not observe an association between intake of the rest of the analyzed nutrients and the conditions we considered. The high prevalence of inadequate intake observed, particularly for vitamins A and E, indicates that it is likely that we will observe a high proportion of individuals with deficiencies in the population. Therefore, a possible explanation for the lack of association between intake and health response could be the existence of a threshold above which these nutrients begin to affect the accumulation of adipose tissue and alterations in glucose metabolism. In addition, obese individuals may require a higher intake of antioxidants to achieve the same serum concentrations as normal weight individuals [64] as an increased OS is associated with increased metabolic utilization of antioxidant factors [65, 66]. Finally, the characteristics of vitamin A and E in the diet have to be considered. Vitamin A is a lipid-soluble vitamin found in specific food types that can be consumed sporadically; and oil, an important source of vitamin E, is difficult to quantify. Thus, these nutrients are not fully represented with only two non-consecutive days of intake observations [39, 41, 42]. Furthermore, magnesium may have an effect on adiposity and serum glucose concentrations through other mechanisms not involved in OS, since in addition to its antioxidant function, it is also involved in energy metabolism [17].

Conclusion

The results of this study suggest that increased dietary magnesium intake is associated with lower BMI and WC. In women without impaired glucose metabolism, it is also associated with lower serum glucose concentrations. These results highlight the importance of an adequate dietary magnesium intake. However, more studies are needed to elucidate the nature of this association.

Abbreviations

ATP:

Adenosine Triphosphate

BLUP:

Best Linear Unbiased Predictor

BMI:

Body Mass Index

CONACYT:

National Council of Science and Technology

DM:

Diabetes Mellitus

EAR:

Estimated Average Requirement

ENSANUT:

National Health And Nutrition Survey

IDF:

International Diabetes Federation

INSP:

National Institute Of Public Health

ISU:

Iowa State University

OS:

Oxidative Stress

PC-Side:

Software For Intake Distribution Estimation

ROS:

Reactive Oxygen Species

SOD:

Superoxide Dismutase

USDA:

United States Department Of Agriculture

WC:

Waist Circumference

WHO:

World Health Organization

References

  1. 1.

    Trends in adult body-mass index in 200 countries from 1975 to 2014. A pooled analysis of 1698 population-based measurement studies with 19.2 million participants. Lancet. 2016;387(10026):1377–96.

  2. 2.

    Instituto Nacional de Salud Pública. Encuesta Nacional de Salud y Nutrición de Medio Camino 2016. Informe de resultados, vol. 68-72. México; 2016. p. 46.

  3. 3.

    Barquera Simón, Campos-Nonato Ismael, Hernández-Barrera Lucía, Pedroza Adolfo, Rivera-Dommarco Juan A. Prevalencia de obesidad en adultos mexicanos, 2000–2012. Salud pública Méx. 2013;55 Suppl 2:S151-S160.

  4. 4.

    Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Investig. 2004;114(12):1752–61.

  5. 5.

    Matsuda M, Shimomura I. Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. Obesity Research & Clinical Practice. 2013;7(5):e330–41.

  6. 6.

    Maddux B, See W, Lawrence J, Goldfine A, Goldfine I, Evans J. Protection against oxidative stress--induced insulin resistance in rat L6 muscle cells by micromolar concentrations of -lipoic acid. Diabetes. 2001;50(2):404–10.

  7. 7.

    Rudich A, Tirosh A, Potashnik R, Hemi R, Kanety H, Bashan N. Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes. Diabetes. 1998;47(10):1562–9.

  8. 8.

    Matsuoka T, Kajimoto Y, Watada H, Kaneto H, Kishimoto M, Umayahara Y, et al. Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells. J Clin Investig. 1997;99(1):144–50.

  9. 9.

    Cho K. lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways. J Biol Chem. 2003;278(37):34823–33.

  10. 10.

    Sen Simmons R. Maternal antioxidant supplementation prevents adiposity in the offspring of Western diet-fed rats. Diabetes. 2010;59(12):3058–65.

  11. 11.

    Berniakovich I, Trinei M, Stendardo M, Migliaccio E, Minucci S, Bernardi P, et al. p66Shc-generated oxidative signal promotes fat accumulation. J Biol Chem. 2008;283(49):34283–93.

  12. 12.

    Palozza P, Krinsky N. β-Carotene and α-tocopherol are synergistic antioxidants. Arch Biochem Biophys. 1992;297(1):184–7.

  13. 13.

    Jeyakumar SVajreswari A. Vitamin a as a key regulator of obesity & its associated disorders: evidences from an obese rat model. Indian J Med Res. 2015;141(3):275.

  14. 14.

    Padayatty S, Katz A, Wang Y, Eck P, Kwon O, Lee J, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003;22(1):18–35.

  15. 15.

    Herrera E, Barbas C. Vitamin E: action, metabolism and perspectives. J Physiol Biochem. 2001;57(1):43–56.

  16. 16.

    Traber M, Atkinson J. Vitamin E, antioxidant and nothing more. Free Radic Biol Med. 2007;43(1):4–15.

  17. 17.

    Morais J, Severo J, Santos L, de Sousa Melo S, de Oliveira Santos R, de Oliveira A, et al. Role of magnesium in oxidative stress in individuals with obesity. Biol Trace Elem Res. 2016;176(1):20–6.

  18. 18.

    Insel P, Ross D, McMahon K, Bernstein M. Discovering nutrition. 4th ed. Burlington, MA, USA: Jones & Bartlett Learning; 2003.

  19. 19.

    Pedroza-Tobías A, Hernández-Barrera L, López-Olmedo N, García-Guerra A, Rodríguez-Ramírez S, Ramírez-Silva I, Villalpando S, Carriquiry A, Rivera JA. Usual vitamin intakes by Mexican population. J Nutr. 2016;146(Suppl):18665–735.

  20. 20.

    Sanchez-Pimienta T, Lopez-Olmedo N, Rodriguez-Ramirez S, Garcia-Guerra A, Rivera J, Carriquiry A, et al. High prevalence of inadequate calcium and Iron intakes by Mexican population groups as assessed by 24-hour recalls. J Nutr. 2016;146(9):1874S–80S.

  21. 21.

    Hosseini B, Saedisomeolia A, Allman-Farinelli M. Association between antioxidant intake/status and obesity: a systematic review of observational studies. Biol Trace Elem Res. 2016;175(2):287–97.

  22. 22.

    Devaux S, Adrian M, Laurant P, Berthelot A, Quignard-Boulangé A. Dietary magnesium intake alters age-related changes in rat adipose tissue cellularity. Magnes Res. 2016;29(4):175–83.

  23. 23.

    Lopez-Ridaura R, Willett W, Rimm E, Liu S, Stampfer M, Manson J, et al. Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care. 2003;27(1):134–40.

  24. 24.

    Moctezuma-Velázquez C, Gómez-Sámano M, Cajas-Sánchez M, Reyes-Molina D, Galindo-Guzmán M, Meza-Arana C, et al. High dietary magnesium intake is significantly and independently associated with higher insulin sensitivity in a Mexican-mestizo population: a brief cross-sectional report. Rev Investig Clin. 2017;69(1).

  25. 25.

    Gao M, Zhao Z, Lv P, Li Y, Gao J, Zhang M, et al. Quantitative combination of natural anti-oxidants prevents metabolic syndrome by reducing oxidative stress. Redox Biol. 2015;6:206–17.

  26. 26.

    Sales C, Santos A, Cintra D, Colli C. Magnesium-deficient high-fat diet: effects on adiposity, lipid profile and insulin sensitivity in growing rats. Clin Nutr. 2014;33(5):879–88.

  27. 27.

    Romero-Martínez M, Shamah-Levy T, Franco-Nunez A, Villalpando S, Cuevas-Nasu L, Gutierrez JP, Rivera-Dommarco JA. National Health and nutrition survey 2012: design and coverage. Salud Publica Mex. 2013;55(Suppl 2):S332–40 (in Spanish).

  28. 28.

    Blanton CA, Moshfegh AJ, Baer DJ, Kretsch MJ. The USDA automated multiple-pass method accurately estimates group total energy and nutrient intake. J Nutr. 2006;136:2594–9.

  29. 29.

    López-Olmedo N, Carriquiry AL, Rodríguez-Ramírez S, Ramírez-Silva I, Espinosa-Montero J, Hernández-Barrera L, Campirano F, Martínez-Tapia B, Rivera JA. Usual intake of added sugars and saturated fats is high while dietary fiber is low in Mexican population. J Nutr. 2016;146(Suppl):1856S–65S.

  30. 30.

    Instituto Nacional de Salud Pública. Bases de datos del valor nutritivo de los alimentos. Compilación del Instituto Nacional de Salud Pública. Cuernavaca,México: Instituto Nacional de Salud Publica; 2012.

  31. 31.

    Lohman TG, Roche AF, Martorell R. Anthropometric standardization reference manual. Champaign, IL: Human Kinetics Publishers; 1988.

  32. 32.

    Habicht JP. Standardization of quantitative epidemiological methods in the field. Bol Oficina Sanit Panam. 1974;76(5):375–84.

  33. 33.

    WHO. Physical status: The use and interpretation of anthropometry. Report of a WHO expert committee. WHO technical report series 854. Geneva: World Health Organization; 1995.

  34. 34.

    Zimmet P, Alberti K. Introduction: globalization and the non-communicable disease epidemic. Obesity. 2006;14(1):1–3.

  35. 35.

    Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2010;34(Supplement_1): S62.

  36. 36.

    Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35(8):1381–95.

  37. 37.

    Medina C, Barquera S, Janssen I. Validity and Reliability of the International Physical Activity Questionnaire Among Mexicans. Kingston and National Institute of Public Health. Cuernavaca. Research Report: Queens University; 2012.

  38. 38.

    WHO. Global recommendations on physical activity for health. Switzerland: Geneva; 2010.

  39. 39.

    Shils M, Olson J, Shike M. Modern nutrition in health and disease. Philadelphia: Lea & Febiger; 1994. Criteria of an adequate diet.

  40. 40.

    Carriquiry A. Assessing the prevalence of nutrient inadequacy. Public Health Nutr. 1999;2(01).

  41. 41.

    Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, D.C.: National Academy Press; 2002.

  42. 42.

    Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington, D.C.: National Academy Press; 2000.

  43. 43.

    Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. Washington. D.C.: National Academy Press; 1999.

  44. 44.

    Willet WC, Howe GR, Kushi LW. Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr l997:65(suppl):1220S–8S.

  45. 45.

    Barquera S, Campos-Nonato I, Hernández-Barrera L, Pedroza A, Rivera-Dommarco JA. Prevalence of obesity in Mexican adults, 2000–2012. Salud Pública Méx. 2013;55(2):S151–60.

  46. 46.

    Beltrán-Sánchez H, Harhay MO, Harhay MM, McElligott S. Prevalence and trends of metabolic syndrome in the adult US population, 1999–2010. J Am Coll Cardiol. 2013;62(8):697–703. https://doi.org/10.1016/j.jacc.2013.05.064.

  47. 47.

    Linhares RS, Horta BL, Gigante DP, Dias-da-Costa JS, Olinto MTA. Distribution of general and abdominal obesity in adults in a city in southern Brazil. Cad Saúde Pública. 2012;28(3):438–47. https://doi.org/10.1590/S0102-311X2012000300004.

  48. 48.

    Xi B, Liang Y, He T. Secular trends in the prevalence of general and abdominal obesity among Chinese adults, 1993–2009. Obes Rev. 2012;13(3):287–96. https://doi.org/10.1111/j.1467-789X.2011.00944.

  49. 49.

    García O, Ronquillo D, Caamaño M, Camacho M, Long K, Rosado J. Zinc, vitamin a, and vitamin C status are associated with leptin concentrations and obesity in Mexican women: results from a cross-sectional study. Nutrition & Metabolism. 2012;9(1):59.

  50. 50.

    Agarwal S, Reider C, Brooks J, Fulgoni V. Comparison of prevalence of inadequate nutrient intake based on body weight status of adults in the United States: an analysis of NHANES 2001–2008. J Am Coll Nutr. 2015;34(2):126–34.

  51. 51.

    Sebastian RS, Cleveland LE, Goldman JD, Moshfegh AJ. Older adults who use vitamin/mineral supplements differ from nonusers in nutrient intake adequacy and dietary attitudes. J Am Diet Assoc. 2007;107:1322–32.

  52. 52.

    He K. Magnesium intake and incidence of metabolic syndrome among young adults. Circulation. 2006;113(13):1675–82.

  53. 53.

    Song Y, Ridker P, Manson J, Cook N, Buring J, Liu S. Magnesium intake, C-reactive protein, and the prevalence of metabolic syndrome in middle-aged and older U.S. women. Diabetes Care. 2005;28(6):1438–44.

  54. 54.

    Park S, Kim S, Bae Y. Relationship between serum calcium and magnesium concentrations and metabolic syndrome diagnostic components in middle-aged Korean men. Biol Trace Elem Res. 2011;146(1):35–41.

  55. 55.

    Mooren F. Magnesium and disturbances in carbohydrate metabolism. Diabetes Obes Metab. 2015;17(9):813–23.

  56. 56.

    Pham PC, Pham PA, Pham SV, Pham PT, Pham PM, Pham PT. Hypomagnesemia: a clinical perspective. Int J Nephrol Renovasc Dis. 2014;7:219–30.

  57. 57.

    Konishi K, Wada K, Tamura T, Tsuji M, Kawachi T, Nagata C. Dietary magnesium intake and the risk of diabetes in the Japanese community: results from the Takayama study. Eur J Nutr. 2015;56(2):767–74.

  58. 58.

    Sheehan JP. Magnesium deficiency and diabetes mellitus. Magnes Trace Elem. 1991–1992;10:215–9.

  59. 59.

    Ryschon TW, Rosenstein DL, Rubinow DR, Niemela JE, Elin RJ, Balaban RS. Relationship between skeletal muscle intracellular ionized magnesium and measurements of blood magnesium. J Lab Clin Med. 1996;127:207–13. https://doi.org/10.1016/S0022-2143(96)90080-3.

  60. 60.

    Schatzkin A, Kipnis V, Carroll R, Midthune D, Subar A, Bingham S, et al. A comparison of a food frequency questionnaire with a 24-hour recall for use in an epidemiological cohort study: results from the biomarker-based observing protein and energy nutrition (OPEN) study. Int J Epidemiol. 2003;32(6):1054–62.

  61. 61.

    Orcholski L, Luke A, Plange-Rhule J, Bovet P, Forrester T, Lambert E, et al. Under-reporting of dietary energy intake in five populations of the African diaspora. Br J Nutr. 2015;113(03):464–72.

  62. 62.

    Lafay L, Mennen L, Basdevant A. Does energy intake underreporting involve all kinds of food or only specific food items? Results from the Fleurbaix Laventie Ville Santé (FLVS) study. Int J Obes Relat Metab Disord. 2000;24(11):1500–6.

  63. 63.

    Suchanek P, Poledne R, Hubacek JA. Dietary intake reports fidelity–fact or fiction? Neuro Endocrinol Lett. 2011;32(Suppl 2):29–31.

  64. 64.

    Vioque J, Weinbrenner T, Asensio L, Castelló A, Young I, Fletcher A. Plasma concentrations of carotenoids and vitamin C are better correlated with dietary intake in normal weight than overweight and obese elderly subjects. Br J Nutr. 2007;97(05):977.

  65. 65.

    Weinbrenner T, Schröder H, Escurriol V, Fito M, Elosua R, Vila J, Marrugat J, Covas M-I. Circulating oxidized LDL is associatedwith increased waist circumference independent of body mass index in men and women. Am J Clin Nutr. 2006;83(1):30–5.

  66. 66.

    Saedisomeolia A, Wood LG, Garg ML, Gibson PG, Wark PA. Supplementation of long chain N-3 polyunsaturated fatty acids increase the utilization of lycopene in cultured airway epithelial cells. J Food Lipids. 2008;15(4):421–32.

Download references

Acknowledgments

Not applicable.

Funding

CONACYT contributed with travel expenses for ACG to work with AC and THM at ISU for a period of six weeks.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Author information

Affiliations

  1. Center for Nutrition and Health Research, National Institute of Public Health, Mexico. Av. Universidad 655, Col. Santa María Ahuacatitlán. Cerrada los pinos y caminera. C.P, 62100, Cuernavaca, Morelos, Mexico

    • Analí Castellanos-Gutiérrez
    •  & Tania G. Sánchez-Pimienta

  2. Department of Statistics, Iowa State University, Ames, Iowa, 50011, USA

    • Alicia Carriquiry

  3. Department of Nutrition, School of Health Science, University of Brasilia, Brasilia - DF, CEP, 70910-900, Brazil

    • Teresa H. M. da Costa

  4. National Council of Science and Technology (CONACYT) - Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico

    • Ana Carolina Ariza

Authors

  1. Search for Analí Castellanos-Gutiérrez in:

  2. Search for Tania G. Sánchez-Pimienta in:

  3. Search for Alicia Carriquiry in:

  4. Search for Teresa H. M. da Costa in:

  5. Search for Ana Carolina Ariza in:

Contributions

ACA conceived the study; ACA, ACG, and TGSP designed the study; ACG wrote the first draft of the manuscript and analyzed data; AC, THM and TGSP contributed to the data analysis; ACA, TGSP, AC, and THM reviewed the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Ana Carolina Ariza.

Ethics declarations

Ethics approval and consent to participate

The survey protocol ENSANUT was approved by the Ethics, Research and Biosafety Committees of the INSP (E&RC: 1033, No. 1108; BC: 1024). All adult participants (≥ 18 years) signed a letter of informed consent. Specific protocol was extent of approval since data was secondary to ENSANUT (E&RC: 889).

Competing interests

All authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Additional files

Additional file 1:

Table S1. STROBE-nut: An extension of the STROBE statement for nutritional epidemiology. STROBE and STROBE-nut recommendations, and page(s) number(s) of the manuscript were information on each item can be found. (DOCX 29 kb)

Additional file 2:

Table S2. Distribution of usual intake of antioxidant nutrients in 20- to 65-year-old Mexican adults. Mean and percentiles of usual intake of vitamins A, C, E, and magnesium in men and women. (DOCX 13 kb)

Additional file 3:

Table S3. Association between intake of antioxidant nutrients, BMI, WC and glucose concentrations in 20- to 65-year-old Mexican adults. Association between intake of antioxidant nutrients, BMI, WC and glucose concentrations, using information from one 24-h recall. (DOCX 14 kb)

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Keywords

  • Obesity
  • Magnesium
  • Glucose
  • Mexico
  • Adult

Nutrition Journal

ISSN: 1475-2891

Contact us