Diet in irritable bowel syndrome

Nutrition Journal

Table 1 Abnormalities in the gastrointestinal endocrine cells that regulate appetite in IBS patients

Gastrointestinal segment	Hormone	Cell density			Hormone function
Gastrointestinal segment	Hormone	IBS-D	IBS-M	IBS-C	Hormone function
Stomach	Ghrelin	Increased	Unchanged	Decreased	Orexigenic (increases appetite)
Stomach	Serotonin	Increased	Unchanged	Decreased	Anorexigenic (decreases appetite)
Duodenum	CCK	Decreased	Unchanged	Unchanged	Anorexigenic (decreases appetite)
Duodenum	Serotonin	Unchanged	Unchanged	Unchanged	See above
Ileum	PYY	Unchanged	Unchanged	Increased	Anorexigenic (decreases appetite)
Ileum	Serotonin	Decreased	Decreased	Decreased	See above
Colon	PYY	Decreased	Unknown	Decreased	See above
Colon	Serotonin	Decreased	Unknown	Decreased	See above
Rectum	PYY	Decreased	Decreased	Decreased	See above
	Enteroglucagon	Decreased	Unknown	Decreased	Anorexigenic (decreases appetite)
	Serotonin	Unchanged	Unknown	Unchanged	See above

IBS-D, IBS patients with diarrhoea as the predominant symptom; IBS-M, IBS patients with alternating diarrhea and constipation; IBS-C, IBS patients with constipation as the predominant symptom.

ISSN: 1475-2891