Table 3 Systematic reviews on Vitamin D for prevention or treatment (in chronological order)
Area | Number of studies | Type | Doses | Conclusion | Reference |
|---|---|---|---|---|---|
Cardiovascular events | 17 | Prospective | ~1000IU | S not SS | 162 |
Cardiometabolic outcomes | 31 | Observ/Trial | Range | No effect | 163 |
Fracture prevention | 7 | Randomised | 10-20 mcg + Ca | No effect Reduced risk | 164 164 |
Physical performance | 8 8 | Observational Intervention | - - | Positive (5/8) Mixed | 165 165 |
Kidney disease (-dialysis) | 16 | RCT | - | Uncertain | 166 |
Kidney disease (+dialysis) | 60 | RCT | - | Uncertain | 167 |
Cystic fibrosis | 3 | (q)RCT | 800-1600IU | No effect | 168 |
Risk of falling | 8 | RCT | 700-1000IU 200-600IU | Reduced risk No effect | 169 169 |
Hypertension | 11 | RCT | - | S - SS | 170 |
Risk of falling | 111* | RT or interv. | - | No effect | 171 |
Fracture prevention | 45 | (q)RCT | - +Ca | No effect S not SS | 172 172 |
Risk of Type 1 diabetes | 5 | Observational | - | Uncertain | 136 |
Parathyroid hormone | 52 | Intervention | _ | Decrease | 173 |
Mortality | 18 | RCT | 2300-2000IU | Uncertain | 174 |
Risk of fall/fracture | 9 | - | - | Decrease (trend) | 175 |
Risk of fracture | 12 | RCT | 700-800IU 400IU | Decrease (trend) No effect | 176 176 |
Risk of fall | 10 | RCT | - | Decrease | 177 |
Bone density Fracture | 17 17 | RCT RCT | - - | Uncertain Reduction | 178 |