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Table 3 Association of secondary BAs with CKD and eGFR among newly-diagnosed type 2 diabetes

From: Circulating concentrations of bile acids and prevalent chronic kidney disease among newly diagnosed type 2 diabetes: a cross-sectional study

 

CKD

 

eGFR

 

OR (95% CI)*

P FDR

β (95% CI)*

P FDR

Total secondary BAs

0.88 (0.74, 1.04)

0.75

 

2.05 (0.58, 3.53)

0.05

Unconjugated secondary BAs

     

DCA

0.92 (0.79, 1.08)

0.75

 

1.19 (-0.27, 2.65)

0.20

LCA

1.00 (0.85, 1.18)

0.99

 

1.54 (0.06, 3.03)

0.09

HCA

0.92 (0.78, 1.08)

0.75

 

1.90 (0.44, 3.36)

0.05

UDCA

0.94 (0.81, 1.11)

0.82

 

1.60 (0.14, 3.05)

0.09

Conjugated secondary BAs

     

GDCA

0.92 (0.78, 1.08)

0.75

 

0.83 (-0.63, 2.28)

0.34

TDCA

0.97 (0.82, 1.14)

0.94

 

-0.27 (-1.72, 1.19)

0.75

GUDCA

0.95 (0.81, 1.12)

0.82

 

0.85 (-0.61, 2.31)

0.34

GHCA

1.00 (0.85, 1.18)

0.99

 

0.24 (-1.25, 1.73)

0.75

  1. *Models were adjusted for age, sex, education, body mass index, smoking status, alcohol consumption, physical activity, hypertension, use of lipid-lowering medication, fasting plasma glycose, triglycerides, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol.
  2. Abbreviation: BA, bile acid CKD; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; OR, odd ratio; FDR, false discovery rate
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Nutrition Journal

ISSN: 1475-2891

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