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Table 4 Literature on the effects of dietary patterns involving dairy on acute infections (N=4)

From: The effect of bovine dairy products and their components on the incidence and natural history of infection: a systematic literature review

Author (Year)

Study population

Exposure details

Infectious disease

Measures of infection risk

N

Age, gender, and health status

Darand et al. (2022) [50]

8,801

Adults, healthy

Food frequency questionnaire evaluated intakes in the previous year of the following: Total dairy (total, low-fat and high-fat)

Milk (total, low-fat and high-fat)

Yogurt (total, low-fat and high-fat)

Cheese

COVID-19 seroprevalence

Multivariate logistic regression: Low-fat dairy: Tertile 3=OR=0.51 (95% CI=0.37-0.69)

p-trend (tertiles 2 and 3)=<0.001

High-fat dairy: Tertile 3=OR=1.40 (95% CI=1.09-1.92)

p-trend=0.03

Total dairy: Tertile 3=OR=1.03 (95% CI=0.76-1.39)

p-trend=0.97

Low-fat milk: Tertile 3=OR=0.47 (95% CI=0.35-0.59)

p-trend=<0.001

High-fat milk: Tertile 3=OR=1.54 (95% CI=1.20-1.97)

p-trend=<0.001

Total milk: Tertile 3=OR=0.74 (95% CI=0.54-1.01)

p-trend=0.06

Low-fat yogurt: Tertile 3=OR=1.12 (95% CI=0.82-1.52)

p-trend=0.31

High-fat yogurt: Tertile 3=OR=1.21 (95% CI=0.93-1.59)

p-trend=0.27

Total yogurt: Tertile 3=OR=1.40 (95% CI=1.04-1.89)

p-trend=0.01

Cheese: Tertile 3=OR=1.80 (95% CI=1.27-2.56)

p-trend=0.001

Yogurt drink: Tertile 3=OR=1.37 (95% CI=0.98-1.91)

p-trend=0.12

Deschasaux-Tanguy et al. (2021) [51]

7,766

Adults, healthy

Food frequency diary evaluated intakes in the previous two years of the following:

Total dairy

Milk

Yogurt

Cheese

COVID-19 seroprevalence

Multivariate logistic regression:

Total dairy:

All COVID cases: OR=1.19 (95% CI=1.06-1.33)

Symptomatic COVID cases: OR=1.12 (95% CI=0.96-1.31)

Asymptomatic COVID cases: OR=1.29 (95% CI=1.10-1.50)

Milk: OR=1.15 (95% CI=1.03-1.27)

Yogurt: OR=1.12 (95% CI=1.00-1.25)

Cheese: OR=0.96 (95% CI=0.84,1.09)

Cameron et al. (2004) [52]

Case: 172

Control: 169

Children, healthy

Food frequency questionnaire evaluated intakes in the preceding two months of the following:

Milk

Cheese

Clinically confirmed Campylobacter jejuni infection

Cheese slices: OR=0.33 (95% CI=0.51-0.71)

Block cheese: OR=0.38 (95% CI=0.19-0.76)

Milk (full-cream): OR=0.53 (95% CI=0.29-0.97)

Reduced-fat milk: Differences NSS (no p-value reported) cases vs. control

Yordanov et al. (2017) [53]

294

Adults, healthy

Questionnaire on frequency of yogurt consumption

Seroprevalence of H. pylori

All cases: Difference NSS (p=0.387) frequent yogurt consumers (≥5 days/week) vs. non-frequent yogurt consumers

CagA+ cases: OR=0.560 (95% CI=0.341-0.921)

  1. CagA Cytotoxin-associated gene A, NSS Not statistically significant, OR Odds ratio, SS Statistically significant
  2. Statistical comparisons that were significant at the p=0.05 level are bolded