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Table 4 Subgroup analyses of all-cause mortality for PC patients

From: Prognostic potential of nutritional risk screening and assessment tools in predicting survival of patients with pancreatic neoplasms: a systematic review

Subgroup

No. of studies

Heterogeneity

Meta

I2(%)

Ph

HR(95%CI)

P

CONUT

Sample size<200

2 [24, 37]

82.7

P = 0.003

2.879(1.072–7.731)

P = 0.036

Sample size>200

5 [19, 20, 30, 35, 36]

92.4

P<0.001

1.722(1.116–2.659)

P = 0.014

Follow-up duration ≤ 5 years

3 [19, 24, 35]

0.0

P = 0.722

1.156(1.065–1.254)

P = 0.001

Follow-up duration > 5 years

4 [20, 36,37,38]

83.9

P<0.001

2.712(1.600-4.596)

P<0.001

Cut-off ≤ 3

5 [19, 24, 35, 37, 38]

92.2

P<0.001

1.727(1.063–2.806)

P = 0.027

Cut-off>3

3 [20, 36, 37]

84.4

P = 0.002

2.741(1.195–6.291)

P = 0.017

Surgery

4 [19, 35, 36, 38]

94.1

P<0.001

1.719(1.047–2.877)

P = 0.032

Other theory

3 [20, 24, 37]

75.4

P = 0.007

2.439(1.259–4.726)

P = 0.008

China

2 [35, 38]

97.9

P<0.001

2.116(0.621–7.207)

P = 0.231

Japan

5 [19, 20, 24, 36, 37]

72.4

P = 0.003

1.874(1.285–2.733)

P = 0.001

GPS

Surgery

4 [19, 23, 31, 35]

31.1

P = 0.226

1.462(1.281–1.669)

P<0.001

Other theory

4 [20, 27, 31, 41]

67.3

P = 0.027

1.470(1.115–1.940)

P = 0.006

Sample size ≤ 200

4 [23, 27, 31, 41]

56.3

P = 0.076

1.693(1.405–2.040)

P<0.001

Sample size>200

4 [19, 20, 31, 35]

0.0

P = 0.440

1.323(1.132–1.545)

P<0.001

Cut-off = 1

5 [19, 20, 23, 31, 41]

11.9

P = 0.339

1.478(1.302–1.677)

P<0.001

Cut-off = 2

2 [27, 35]

86.9

P = 0.006

1.351(0.937–1.950)

P = 0.108

Advanced stage

5 [20, 27, 31, 35, 41]

62.4

P = 0.031

1.333(1.062–1.673)

P = 0.013

Early stage

3 [19, 23, 31]

0.0

P = 0.372

1.517(1.318–1.746)

P<0.001

PNI

Cut-off ≤ 45

6 [23, 27, 29, 31, 44, 46, 47]

71.3

P = 0.001

1.740(1.550–1.950)

P<0.001

Cut-off>45

9 [19, 20, 24,25,26, 28, 38, 45]

0.0

P = 0.581

1.480(1.340–1.630)

P<0.001

Advanced stage

9 [20, 24, 26,27,28,29, 31, 44, 46]

71.4

P<0.001

1.430(1.170–1.750)

P<0.001

Early stage

8 [19, 23, 25, 28, 31, 38, 45, 47]

0.0

P = 0.798

1.520(1.340–1.710)

P<0.001

Surgery

5 [19, 23, 25, 31, 38]

76.3

P = 0.001

1.530(1.170–2.020)

P = 0.002

Other theory

11 [20, 24, 26,27,28,29, 31, 44,45,46,47]

0.0

P = 0.713

1.450(1.310–1.600)

P<0.001

Sample size ≤ 200

9 [23,24,25, 27,28,29, 31, 44, 46]

0.0

P = 0.814

1.460(1.270–1.670)

P<0.001

Sample size>200

8 [19, 20, 26, 28, 31, 38, 45, 47]

75.6

P<0.001

1.490(1.230–1.810)

P<0.001