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Table 5 The mean of fold changes of MicroRNAs of study participants at base line and after 12 weeks trial

From: Effects of vitamin D supplementation on liver fibrogenic factors, vitamin D receptor and liver fibrogenic microRNAs in metabolic dysfunction-associated steatotic liver disease (MASLD) patients: an exploratory randomized clinical trial

 

Baseline

End of trial

Changes from baseline

Placebo

Mean ± SD

(CI)

Vitamin D

Mean ± SD

(CI)

P*

Placebo

Mean ± SD

(CI)

Vitamin D

Mean ± SD

(CI)

P$

Placebo

Mean ± SE

(CI)

Vitamin D

Mean ± SE

(CI)

P¶

MiR-21

(Crude)

1.50 ± 1.64

(0.95,2.04)

1.50 ± 0.81

(0.96,2.05)

0.99

3.00 ± 1.80

(2.3,3.7)

1.67 ± 1.60

(0.95,2.4)

0.03

1.49 ± 2.10

(0.78,2.2)

0.16 ± 1.82

(-0.55,0.88)

0.01

(Adjusted)

-

-

-

3.01 ± 1.7

(2.3,3.7)

1.65 ± 1.7

(0.92,2.4)

0.01

1.5 ± 0.36

(0.78,2.2)

0.15 ± 0.36

(-0.58,0.87)

0.01

MiR-122 (Crude)

1.19 ± 1.34

(0.68,1.7)

1.53 ± 1.1

(1.0,2.0)

0.35

2.11 ± 1.75

(1.5,2.7)

0.75 ± 0.67

(0.2,1.3)

< 0.001

0.93 ± 1.26

(0.42,1.3)

-0.77 ± 0.98

(-1.2,-0.26)

< 0.001

(Adjusted)

-

-

-

2.21 ± 1.05

(1.7,2.7)

0.65 ± 1.05

(0.2,1.1)

< 0.001

0.86 ± 0.23

(0.40,1.31)

-0.70 ± 0.23

(-1.1,-0.25)

< 0.001

MiR-34a (Crude)

1.48 ± 1.03

(1.1,1.9)

1.02 ± 0.86

(0.63,1.4)

0.11

1.54 ± 1.00

(1.1,1.9)

1.07 ± 0.94

(0.7,1.5)

0.98

0.05 ± 1.09

(-0.18,0.64)

0.05 ± 1.30

(-0.54,0.28)

0.22

(Adjusted)

-

-

-

1.49 ± 0.96

(1.1,1.9)

1.12 ± 0.96

(0.7,1.5)

0.22

0.24 ± 0.21

(-0.18,0.66)

-0.14 ± 0.21

(-0.56,0.28)

0.22

  1. *Obtained by Independent sample t-test
  2. $ Obtained by Repeated measure ANOVA
  3. ¶ Obtained by ANCOVA