Table 4 Fibrogenic factors of study participants at base line and after 12 weeks trial

Laminin (ng/mL) (Crude)

73.6 ± 20.3

(66.0,81.3)

71.5 ± 15.6

(63.8,79.1)

0.69

78.6 ± 29.3

(68.0,89.1)

60.9 ± 20.1

(50.3,71.5)

0.01

5.1 ± 4.1

(-3.3,13.4)

-10.7 ± 4.1

(-19.1,-2.3)

0.01

(Adjusted)

-

-

-

77.5 ± 20.1

(69.0,86.0)

61.9 ± 20.1

(53.4,70.5)

0.01

4.9 ± 4.2

(-3.6,13.5)

-10.6 ± 4.2

(-19.1,-2.1)

0.01

Hyaluronic acid (ng/mL) (Crude)

106.7 ± 22.7

(96.2,117.2)

121.8 ± 26.9

(111.4,132.3)

0.04

103.2 ± 35.0

(91.0,115.4)

93.1 ± 21.1

(80.9,105.2)

0.005

-3.5 ± 34.5

(-18.7,4.1)

-28.7 ± 22.1

(-36.3,13.5)

0.04

(Adjusted)

-

-

-

107.2 ± 27.3

(95.6,118.8)

89.1 ± 27.3

(77.4,100.7)

0.04

-7.1 ± 5.7

(-18.7,4.6)

-25.2 ± 5.7

(-36.8,13.6)

0.03

Collagen type IV (ng/mL) (Crude)

264.6 ± 34.8

(246.1,283.1)

264.4 ± 51.7

(245.9,282.9)

0.99

256.1 ± 33.4

(236.5,275.6)

237.9 ± 56.7

(218.3,257.4)

0.11

-8.5 ± 38.6

(-23.3,6.3)

-26.5 ± 35.7

(-41.3,11.7)

0.09

(Adjusted)

-

-

-

254.8 ± 35.2

(240.0,269.7)

239.1 ± 35.2

(224.3,254.0)

0.14

-9.7 ± 7.3

(-24.5,5.1)

-25.4 ± 7.3

(-40.2,10.5)

0.14