Association of early dietary fiber intake and mortality in septic patients with mechanical ventilation based on MIMIC IV 2.1 database: a cohort study

Wang, Xiaoyan; Miao, Shuchuan; Yang, Yuanwei; Yang, Qilin; Meng, Dejiao; Liang, Hong

doi:10.1186/s12937-023-00894-1

Table 4 Primary and second outcomes

From: Association of early dietary fiber intake and mortality in septic patients with mechanical ventilation based on MIMIC IV 2.1 database: a cohort study

		Non-adjust Model		Model 1
	N (%)	HR/OR/β(95%CI)	p value	HR/OR/β(95%CI)	P value
Primary outcomes
28-day mortality, n (%)
LFI Group n = 655	199 (30.4)	1(Ref)		1(Ref)
MFI Group n = 194	39(20.1)	0.63 (0.45 ~ 0.89)	0.008	0.64 (0.45 ~ 0.91)	0.011
HFI Group n = 208	69(33.2)	1.1 (0.84 ~ 1.44)	0.502	1.18 (0.87 ~ 1.62)	0.291
60-day mortality, n (%)
LFI Group n = 655	231 (35.3)	1(Ref)		1(Ref)
MFI Group n = 194	50 (25.8)	0.69 (0.51 ~ 0.93)	0.016	0.69(0.51 ~ 0.95)	0.022
HFI Group n = 208	83 (39.9)	1.15 (0.89 ~ 1.47)	0.29	1.24 (0.93 ~ 1.66)	0.137
90-day mortality, n (%)
LFI Group n = 655	251 (38.3)	1(Ref)		1(Ref)
MFI Group n = 194	56 (28.9)	0.7 (0.53 ~ 0.94)	0.017	0.72 (0.54 ~ 0.97)	0.031
HFI Group n = 208	86 (41.3)	1.1 (0.86 ~ 1.4)	0.462	1.18 (0.92 ~ 1.60)	0.18
1-year mortality, n (%)
LFI Group n = 655	298 (45.5)	1(Ref)		1(Ref)
MFI Group n = 194	75 (38.7)	0.79 (0.61 ~ 1.01)	0.065	0.79 (0.61 ~ 1.02)	0.074
HFI Group n = 208	108 (51.9)	1.18 (0.94 ~ 1.47)	0.147	1.26 (0.98 ~ 1.63)	0.066
Second Outcomes
Hospital death
LFI Group n = 655	184 (28.1)	1(Ref)		1(Ref)
MFI Group n = 194	36 (18.6)	0.58 (0.39 ~ 0.87)	0.008	0.60 (0.39 ~ 0.93)	0.022
HFI Group n = 208	59 (28.4)	1.01 (0.72 ~ 1.43)	0.939	1.25 (0.83 ~ 1.87)	0.292
ICU death
LFI Group n = 655	151 (23.1)	1(Ref)		1(Ref)
MFI Group n = 194	31 (16)	0.63 (0.42 ~ 0.97)	0.036	0.67 (0.43 ~ 1.05)	0.080
HFI Group n = 208	47 (22.6)	0.97 (0.67 ~ 1.41)	0.891	1.12 (0.73 ~ 1.72)	0.592
Length of hospital saty
LFI Group n = 655		0(Ref)		0(Ref)
MFI Group n = 194		-2.18 (-4.59 ~ 0.22)	0.076	-0.96 (-3.33 ~ 1.40)	0.425
HFI Group n = 208		-3.09 (-5.43 ~ -0.75)	0.01	-1.36 (-3.82 ~ 1.10)	0.281
Length of ICU saty
LFI Group n = 655		0(Ref)		0(Ref)
MFI Group n = 194		-1.52 (-2.77 ~ -0.27)	0.017	-0.84 (-2.06 ~ 0.38)	0.176
HFI Group n = 208		-1.84 (-3.05 ~ -0.62)	0.003	-0.95 (-2.22 ~ 0.31)	0.14
Length of Mechanical Ventilation
LFI Group n = 655		0(Ref)		0(Ref)
MFI Group n = 194		-0.93 (-1.74 ~ -0.13)	0.023	-0.47 (-1.26 ~ 0.32)	0.247
HFI Group n = 208		-0.77 (-1.56 ~ 0.01)	0.053	-0.16 (-0.99 ~ 0.66)	0.695
Ventilator-associated pneumonia
LFI Group n = 655	140 (21.4)	1(Ref)		1(Ref)
MFI Group n = 194	38 (19.6)	0.9 (0.6 ~ 1.34)	0.591	0.98 (0.65 ~ 1.49)	0.939
HFI Group n = 208	43 (20.7)	0.96 (0.65 ~ 1.41)	0.829	1.04 (0.68 ~ 1.60)	0.841
Early Nosocomial infections
LFI Group n = 655	246 (37.6)	1(Ref)		1(Ref)
MFI Group n = 194	66 (34)	0.86 (0.61 ~ 1.2)	0.37	0.92 (0.65 ~ 1.31)	0.655
HFI Group n = 208	67 (32.2)	0.79 (0.57 ~ 1.1)	0.163	0.89 (0.62 ~ 1.27)	0.51
Late Nosocomial infections
LFI Group n = 655	335 (51.1)	1(Ref)		1(Ref)
MFI Group n = 194	80 (41.2)	0.67 (0.48 ~ 0.93)	0.016	0.75 (0.53 ~ 1.05)	0.090
HFI Group n = 208	90 (43.3)	0.73 (0.53 ~ 1)	0.048	0.87 (0.61 ~ 1.23)	0.421
Clostridium difficile infection
LFI Group n = 655	25 (3.8)	1(Ref)		1(Ref)
MFI Group n = 194	5 (2.6)	0.67 (0.25 ~ 1.77)	0.414	0.74 (0.27 ~ 2.00)	0.553
HFI Group n = 208	10 (4.8)	1.27 (0.6 ~ 2.7)	0.529	1.62 (0.70 ~ 3.78)	0.262

Model 1: Adjust for age, BMI, SOFA, SAPSII, CCI, Vasoactive agents, Norepinephrine equivalents, feeding route, Early enteral nutrition and actual energy intake. Actual energy intake includes PN, EN and non-nutrient energy intake (dextrose and propofol)
Abbreviations: HR Hazard ratio, OR Odds ratio, CI Confidence interval, BMI Body Mass Index, SOFA Sequential Organ Failure Assessment, SASPII Simplified Acute Physiology Score II, CCI Charlson comorbidity index

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