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Table 2 Prospective association between vitamin K status and echocardiographic measurements in 405 participants

From: High vitamin K status is prospectively associated with decreased left ventricular mass in women: the Hoorn Study

 

Quartiles of dp-ucMGP (pmol/L)

 

Quartile 1

Quartile 2

Quartile 3

Quartile 4a

P-trend

LVMI (g/m2.7)b

 Men n=206

40.9±9.2

40.7±10.4

43.6±13.3

45.2±11.7

 

 Model 1

-1.8 (-6.6; 3.0)

-0.7 (-5.4; 4.0)

2.1 (-2.9; 7.1)

Ref

0.353

 Model 2

-1.3 (-6.4; 3.7)

-0.5 (-5.2; -4.1)

1.8 (-3.1; 6.8)

Ref

0.611

 Women n=199

35.6±9.3

38.9±7.7

45.1±12.5

46.7±15.6

 

 Model 1

-6.5 (-11.2;-1.8)

-7.2 (-11.9; -2.6)

-0.3 (-4.8; 4.2)

Ref

<0.001

 Model 2

-5.0 (-10.5; 0.4)

-6.8 (-11.8; -1.8)

0.4 (-2.9; 3.7)

Ref

<0.001

LVEF (%)b

53.4±9.2

53.3±9.8

52.0±11.2

52.3±10.2

 

 Model 1

1.3 (-1.9; 4.5)

1.0 (-2.1; 4.1)

1.3 (-1.9; 4.4)

Ref

0.48

 Model 2

1.1 (-2.4; 4.5)

0.8 (-2.4; 3.9)

1.1 (-2.1; 4.3)

Ref

0.61

LAVI (mL/m2)b

24.0±9.4

25.2±10.1

26.0±10.6

28.0 ±18.0

 

 Model 1

-1.8 (-5.1; 1.4)

0.50 (-2.6; 3.6)

-0.8 (-4.0; 2.3)

Ref

0.43

 Model 2

-0.1 (-3.3; 3.3)

0.9 (-2.2; 3.9)

-0.4 (-3.5; 2.6)

Ref

0.79

  1. Model 1: Adjusted for baseline echo value (i.e. LVMI at follow-up adjusted for baseline LVMI), follow-up duration, age, sex and glycemic status
  2. Model 2: Adjusted for model 1 and physical activity, smoking, BMI, systolic blood pressure, total cholesterol, HbA1c, education, prior CVD, BNP and eGFR
  3. Abbreviations: LVMI left ventricle mass index, LVEF left ventricular ejection fraction, LAVI left atrium volume index
  4. aQuartile 4 indicates the highest dp-ucMGP concentration and therefore reflects the lowest vitamin K status
  5. bMean echocardiographic measures at follow-up
  6. P-for interaction vitamin K status and LVMI by sex=0.07
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Nutrition Journal

ISSN: 1475-2891

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