Table 5 Association analysis of composite gene score of vitamin D SNPs (GC, CYP2R1 and DHCR7) used as a genetic Instrument for their association with T2D
VitD_T2D | N | OR | LCI | UCI | P_Val | Z score | Direction |
|---|---|---|---|---|---|---|---|
AIDHS/SDS | 2388 | 1.004 | 1.00 | 1.01 | 2.30E-02 | ||
SIKH REPLICATION | 1846 | 1.002 | 1.00 | 1.01 | 4.11E-01 | ||
SOUTH ASIAN META | 4234 | 1.003 | 1.00 | 1.01 | 2.90E-02 | 2.19 | + + |
Twins UK | 3679 | 0.89 | 0.56 | 1.42 | 6.26E-01 | ||
1958 BC | 4993 | 1.00 | 0.99 | 1.05 | 7.92E-01 | ||
CCHS/CGPS/CIHDS | 28,372 | 1.00 | 0.99 | 1.004 | 6.19E-01 | ||
PREVEND | 3649 | 1.00 | 0.98 | 1.03 | 6.79E-01 | ||
Meta-Analysis | 44,927 | 1.002 | 1.001 | 1.005 | 1.20E-01 | 1.54 | + + – + + + |