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Table 2 HR (95% CIs) of pancreatic cancer, by quartile of each fatty acid

From: Dietary intake of fatty acids and risk of pancreatic cancer: Golestan cohort study

Fat intake Quartiles of fat intakes P-Trend Continuous
Q1 Q2 Q3 Q4
Total fat      0.62 1.004(0.98-1.02)
 Range (gday-1) 7.46-60.03 60.03-73.57 73.57-88.02 88.02-304.73   
 Median (gday-1) 50.46 67.25 80.19 99.88
 Cases/controls 20/11722 18/11732 14/11730 22/11720
 Multivariate HR (95% CI) 1 0.91(0.48-1.71) 0.54(0.24-1.21) 1.07(0.44-2.59)
SFAa
 4:0      0.35 0.91 (0.76-1.10)
  Range (gday-1) 0.00-0.25 0.25-0.39 0.39-0.63 0.63-9.99   
  Median (gday-1) 0.17 0.31 0.49 1.03
  Cases/controls 20/11720 13/11732 23/11724 18/11727
  Multivariate HR (95% CI) 1 0.70(0.34-1.44) 1.001(0.51-1.92) 0.73(0.36-1.46)
 6:0      0.04 0.82 (0.68-0.99) *
  Range (gday-1) 0.00-0.19 0.19-0.30 0.30-0.52 0.52-9.99   
  Median (gday-1) 0.14 0.24 0.38 3.74
  Cases/controls 23/11719 14/11727 25/11733 12/11732
  Multivariate HR (95% CI) 1 0.64(0.32-1.28) 0.81(0.43-1.53) 0.51(0.24-1.04)
 8:0      0.01 0.84(0.74-0.96) *
  Range (gday-1) 0.00-0.18 0.18-0.27 0.27-0.55 0.55-10.00   
  Median (gday-1) 0.13 0.22 0.35 5.72
  Cases/controls 23/11709 17/11736 23/11725 11/11734
  Multivariate HR (95% CI) 1 0.70(0.37-1.32) 0.65(0.34-1.24) 0.38(0.18-0.79)*
 10:0      0.55 0.93 (0.75-1.16)
  Range (gday-1) 0.00-0.36 0.36-0.59 0.59-0.90 0.90-9.99   
  Median (gday-1) 0.24 0.47 0.72 1.25
  Cases/controls 19/11722 14/11727 20/11731 21/11724
  Multivariate HR (95% CI) 1 0.82(0.40-1.68) 1.09(0.56-2.13) 0.82(0.40-1.65)
 12:0      0.37 0.89 (0.69-1.14)
  Range (gday-1) 0.00-0.29 0.29-0.46 0.46-0.69 0.69-9.99   
  Median (gday-1) 0.21 0.37 0.55 0.94
  Cases/controls 20/11722 10/11733 22/11724 22/11725
  Multivariate HR (95% CI) 1 0.55(0.25-1.19) 1.13(0.58-2.18) 0.81(0.40-1.64)
 14:0      0.78 1.04 (0.77-1.41)
  Range (gday-1) 0.10-0.85 0.85-1.32 1.32-1.93 1.93-9.91   
  Median (gday-1) 0.57 1.08 1.59 2.47
  Cases/controls 17/11726 13/11732 19/11726 25/11720
  Multivariate HR (95% CI) 1 0.88(0.41-1.85) 1.17(0.57-2.43) 1.06(0.47-2.37)
 16:0      0.30 0.91 (0.77-1.08)
  Range (gday-1) 1.09-8.20 8.20-10.26 10.26-12.67 12.67-54.39   
  Median (gday-1) 6.84 9.27 11.34 14.73
  Cases/controls 19/11725 13/11732 19/11726 23/11721
  Multivariate HR (95% CI) 1 0.53(0.24-1.18) 0.72(0.32-1.63) 0.68(0.21-2.12)
 18:0      0.01 1.03(1.01-1.07)
  Range (gday-1) 0.61-18.17 18.17-24.65 24.65-30.90 30.90-234.84   
  Median (gday-1) 12.58 21.68 27.68 35.78
  Cases/controls 16/11728 18/11726 14/11732 26/11718
  Multivariate HR (95% CI) 1 1.21(0.58-2.54) 1.24(0.54-2.87) 2.57(1.03-6.41)*
 20:0      0.33 -
  Range (gday-1) 0.00-0.09 0.09-0.14 0.14-0.18 0.18-1.08   
  Median (gday-1) 0.06 0.12 0.16 0.21
  Cases/controls 21/11722 10/11712 20/11738 23/11732
  Multivariate HR (95% CI) 1 0.53(0.24-1.18) 0.97(0.47-2.01) 1.25(0.53-2.92)
 22:0      0.01 -
  Range (gday-1) 0.00-0.08 0.08-0.11 0.11-0.15 0.15-1.08   
  Median (gday-1) 0.05 0.10 0.13 0.17
  Cases/controls 18/11719 13/11726 20/11738 23/11721
  Multivariate HR (95% CI) 1 0.74(0.34-1.59) 1.47(0.70-3.08) 1.80(0.76-4.28)
 24:0      <0.001 0.69(0.60-0.80) *
  Range (gday-1) 0.00-2.60 2.60-3.69 3.69-4.82 4.82-9.99   
  Median (gday-1) 1.90 3.17 4.20 5.80
  Cases/controls 36/11704 8/11737 13/11731 17/11726
  Multivariate HR (95% CI) 1 0.24(0.11-0.52) * 0.36(0.18-0.69)* 0.42(0.22-0.81)*
 Odd carbon Fatty acids (13:0,15:0,17:0)      <0.001 0.76(0.67-0.85) *
  Range (gday-1) 0.00-1.65 1.65-3.07 3.07-5.85 5.85-10.00   
  Median (gday-1) 1.24 2.22 4.29 7.78
  Cases/controls 32/11713 19/11725 15/11729 8/11737
  Multivariate HR (95% CI) 1 0.72(0.40-1.28) 0.49(0.26-0.91)* 0.27(0.12-0.61)*
 Long Chain fatty acids (>20C)      <0.001 0.71(0.61-0.82) *
  Range (gday-1) 0.00-2.79 2.79-3.95 3.95-5.15 5.15-10.80   
  Median (gday-1) 2.05 3.41 4.50 6.18
  Cases/controls 36/11709 8/11733 13/11730 17/11726
  Multivariate HR (95% CI) 1 0.24(0.11-0.52) * 0.36(0.18-0.69)* 0.42(0.22-0.81)*
Total SFA      0.01 1.05 (1.01-1.09) *
 Range (gday-1) 1.78-30.28 30.28-39.22 39.22-47.94 47.94-270.28   
 Median (gday-1) 23.72 35.12 43.29 54.77
 Cases/controls 19/11725 18/11725 11/11736 26/11718
 Multivariate HR (95% CI) 1 0.95(0.46-1.96) 0.73(0.29-1.82) 1.63(0.56-4.75)
MUFAa:
 16:1 undifferentiated      0.06 0.50(0.24-1.03)
  Range (gday-1) 0.026-0.54 0.54-0.76 0.76-1.03 1.03-7.53   
  Median (gday-1) 0.41 0.65 0.88 1.28
  Cases/controls 23/11718 14/11731 15/11730 22/11725
  Multivariate HR (95% CI) 1 0.54(0.27-1.08) 0.50(0.25-1.03) 0.42(0.20-0.90)*
 18:1 undifferentiated      0.04 0.92(0.85-0.99) *
  Range (gday-1) 1.38-13.57 13.57-17.16 17.16-21.33 21.33-80.80   
  Median (gday-1) 11.22 15.39 19.04 24.89
  Cases/controls 19/11725 20/11724 19/11727 16/11728
  Multivariate HR (95% CI) 1 0.65(0.32-1.32) 0.54(0.23-1.25) 0.34(0.11-1.05)
 20:1      0.91 1.00(0.91-1.10)
  Range (gday-1) 0.00-0.16 0.16-.020 0.20-0.29 0.29-9.99   
  Median (gday-1) 0.12 0.17 0.23 4.14
  Cases/controls 16/11566 17/11575 21/11573 20/11580
  Multivariate HR (95% CI) 1 0.84(0.41-1.71) 1.39(0.69-2.79) 1.12(0.57-2.20)
Total MUFA      0.036 0.92(0.86-0.99) *
 Range (gday-1) 1.58-14.59 14.59-18.46 18.46-22.94 22.94-89.58   
 Median (gday-1) 12.09 16.55 20.47 26.74
 Cases/controls 19/11725 20/11724 19/11726 16/11729
 Multivariate HR (95% CI) 1 0.68(0.34-1.36) 0.50(0.22-1.16) 0.32(0.10.0.99)*
PUFA n-6:
 20:2n-6      0.81 -
  Range (gday-1) 0.00-0.003 0.003-0.006 0.006-0.009 0.009-0.096   
  Median (gday-1) 0.00 0.00 0.01 0.01
  Cases/controls 17/11214 19/12240 20/11671 18/11779
  Multivariate HR (95% CI) 1 1.67(0.84-3.32) 1.90(0.95-3.80) 1.60(0.76-3.39)
 18:2n-6      0.78 0.97(0.83-1.14)
  Range (gday-1) 0.00-0.79 0.79-1.67 1.67-2.66 2.66-37.93   
  Median (gday-1) 0.18 1.23 2.12 3.61
  Cases/controls 22/11685 18/11762 19/11729 15/11728
  Multivariate HR (95% CI) 1 1.24(0.65-2.37) 1.26(0.66-2.41) 0.95(0.46-1.96)
 18:2 n-6 (CLA)      0.39 -
  Range (gday-1) 0.00-0.00 0.00-0.00 0.00-0.00 0.00-0.20   
  Median (gday-1) 0.00 0.00 0.00 0.01
  Cases/controls 40/22510 1/928 14/10440 19/13026
  Multivariate HR (95% CI) 1 0.66(0.09-4.83) 0.94(0.50-1.75) 0.95(0.52-1.70)
18:2 Undifferentiated      0.08 0.92(0.84-1.01)
  Range (gday-1) 0.47-5.71 5.71-7.41 7.41-9.76 9.76-123.04   
  Median (gday-1) 4.68 6.56 8.39 12.56
  Cases/controls 23/11721 22/11723 13/11732 16/11728
  Multivariate HR (95% CI) 1 0.61(0.32-1.17) 0.40(0.18-0.88)* 0.47(0.19-1.15)
18:3 Undifferentiated      0.14 0.31(0.06-1.48)
  Range (gday-1) 0.09-0.56 0.56-0.72 0.72-0.91 0.91-6.08   
  Median (gday-1) 0.46 0.64 0.80 1.06
  Cases/controls 20/11715 18/11734 16/11722 20/11733
  Multivariate HR (95% CI) 1 0.82(0.40-1.69) 0.63(0.27-1.47) 0.68(0.24-1.89)
20:4 Undifferentiated      0.73 0.98(0.88-1.08)
  Range (gday-1) 0.00-0.17 0.17-0.25 0.25-0.44 0.44-9.99   
  Median (gday-1) 0.13 0.21 0.31 4.77
  Cases/controls 23/11464 20/11486 17/11482 13/11486
  Multivariate HR (95% CI) 1 0.87(0.47-1.59) 0.66(0.34-1.27) 0.38(0.18-0.78)*
PUFA n-3:
 20:5n-3(EPA)      0.74 -
  Range (gday-1) 0.00-0.01 0.01-0.02 0.02-0.04 0.04-1.59   
  Median (gday-1) 0.00 0.01 0.02 0.06
  Cases/controls 19/11686 21/11696 17/11791 17/11731
  Multivariate HR (95% CI) 1 1.19(0.63-2.23) 0.95(0.48-1.90) 0.84(0.40-1.75)
 22:5n-3(DPA)      0.12 -
  Range (gday-1) 0.00-0.01 0.01-0.03 0.03-0.05 0.05-0.55   
  Median (gday-1) 0.01 0.02 0.04 0.06
  Cases/controls 20/11689 19/11744 17/11699 18/11772
  Multivariate HR (95% CI) 1 1.00(0.53-1.88) 0.95(0.49-1.84) 0.66(0.33-1.35)
 18:3n-3(ALA)      0.45 1.88(0.35-9.90)
  Range (gday-1) 0.00-0.02 0.02-0.03 0.03-0.05 0.05-4.71   
  Median (gday-1) 0.02 0.03 0.04 0.08
  Cases/controls 19/11712 14/11692 19/11764 22/11736
  Multivariate HR (95% CI) 1 0.76(0.36-1.59) 1.18(0.57-2.41) 1.64(0.77-3.48)
 22:6n-3(DHA)      0.28 0.09(0.001-7.25)
  Range (gday-1) 0.00-0.03 0.03-0.06 0.06-0.09 0.09-1.62   
  Median (gday-1) 0.02 0.04 0.07 0.13
  Cases/controls 20/11688 20/11738 15/11750 19/11728
  Multivariate HR (95% CI) 1 1.05(0.56-1.97) 0.81(0.41-1.63) 0.69(0.34-1.39)
Total PUFAa      0.05 0.91(0.84-1.00)
 Range (gday-1) 0.66-6.67 6.67-8.62 8.62-11.29 11.29-125.45   
 Median (gday-1) 5.49 7.64 9.74 14.38
 Cases/controls 23/11721 22/11722 11/11734 18/11727
 Multivariate HR (95% CI) 1 0.72(0.38-1.35) 0.24(0.10-0.57) * 0.48(0.19-1.17)
Total n-3a      0.52 0.52(0.07-3.76)
 Range (gday-1) 0.00-0.10 0.10-0.16 0.16-0.24 0.24-4.90   
 Median (gday-1) 0.07 0.13 0.19 0.33
 Cases/controls 17/11716 23/11717 17/11738 17/11733
 Multivariate HR (95% CI) 1 1.42(0.75-2.69) 1.11(0.54-2.25) 0.70(0.32-1.53)
Total n-6a      0.77 0.97(0.83-1.14)
 Range (gday-1) 0.00-0.79 0.79-1.68 1.68-2.68 2.68-37.93   
 Median (gday-1) 0.19 1.24 2.12 3.61
 Cases/controls 22/11721 18/11727 19/11722 15/11734
 Multivariate HR (95% CI) 1 1.24(0.65-2.39) 1.26(0.66-2.42) 0.95(0.46-1.96)
Total trans      0.05 1.09(0.99-1.20)
 Range (gday-1) 0.00-4.60 4.60-6.56 6.56-8.35 8.35-70.12   
 Median (gday-1) 3.01 5.67 7.48 9.66
 Cases/controls 20/11725 16/11727 15/11731 25/11721
 Multivariate HR (95% CI) 1 0.89(0.43-1.83) 1.10(0.51-2.39) 1.92(0.84-4.41)
  1. HR (95%CI) for Cox proportional hazards regression model adjusted for energy and total fat intake, BMI, age, gender, marital status, residence, smoking, diabetes, physical activity, opium consumption, family history of cancer, ethnicity, wealth score and education
  2. aSFA Saturated fatty acids, MUFA Mono unsaturated fatty acids, PUFA Poly unsaturated fatty acids, TFA Trans fatty acids, n-3: Omega-3 fatty acids, n-6: Omega-6 fatty acids
  3. *Significant difference between quartiles (P<0.05)