Skip to main content

Table 1 Characteristics of included studies

From: Chitosan modifies glycemic levels in people with metabolic syndrome and related disorders: meta-analysis with trial sequential analysis

Authors (Ref) Publication year Age mean (SD) control/intervention Sample size (control/intervention) Country/population Study design Intervention (name and daily dose) Duration (weeks) Presented data Participant recruitment methods Results
Zhao [41] 2017 67.8 (7.5) / 68.5 (8.0) 50 / 50 China / diabetes Parallel 0.1 g/d 42 weeks Glucose and HbA1c Not stated Decrease
Cornelli-3mon [31] 2017 47.0 (3.75) / 46.4 (4.42) 48 / 49 Italy / obese Parallel 1.6 g/d 13 weeks (3 month) Glucose Not stated Decrease
Cornelli-6mon [31] 2017 47.0 (3.75) / 46.4 (4.42) 48 / 49 Italy / obese Parallel 1.6 g/d 26 weeks (6 month) Glucose Not stated Decrease
Cornelli-9mon [31] 2017 47.0 (3.75) / 46.4 (4.42) 48 / 49 Italy / obese Parallel 1.6 g/d 38 weeks (9 month) Glucose Not stated Decrease
Cornelli-12mon [31] 2017 47.0 (3.75) / 46.4 (4.42) 48 / 49 Italy / obese Parallel 1.6 g/d 51 weeks (12 month) Glucose Not stated No effect
Trivedi-90 day [42] 2016 36.3(10.5)/35.5(11.2) 64/32 India / overweight and obese Parallel 2.5 g/d 12 weeks HbA1c Not stated Decrease
Trivedi-45 day [42] 2016 36.3(10.5)/35.5(11.2) 64/32 India / overweight and obese Parallel 2.5 g/d 6 weeks HbA1c Not stated No effect
Kim [33] 2014 54.4 (2.02) / 57.8 (1.78) 26 / 25 Korea / prediabetes Parallel 1.5 g/d 12 weeks Glucose, Insulin and HbA1c Recruited from Hospital and advertisement in local newspapers Decrease:Glucose and HbAIc;No effect: Insulin
Bays-4.5 g [39] 2013 49.1 (11.2) / 52.0 (11.3) 35 / 33 USA / dyslipidemia Parallel 4.5 g/d 6 weeks Glucose and Insulin Recruited in response to advertisements or from study site databases No effect
Bays-1.5 g [39] 2013 50.9 (10.3) / 52.0 (11.3) 35 / 32 USA / dyslipidemia Parallel 1.5 g/d 6 week Glucose and Insulin Recruited in response to advertisements or from study site databases No effect
Hernández-González [32] 2010 46.1 (6.3) /41.6 (6.3) 6月6日 Mexico / obese Parallel 2.25 g/d 13 weeks Glucose Not stated No effect
Lehtimäki-carrier [29] 2005 43.5 (8.8) / 43.9 (8.9) 29 / 29 Finn / hypercholesterolaemic Crossover 2.4 g/d 13 weeks Glucose Invitation letters No effect
Lehtimäki-noncarrier [29] 2005 44.8 (7.7) / 45.0 (7.8) 55 / 55 Finn/hypercholesterolaemic Crossover 2.4 g/d 13 weeks Glucose Invitation letters No effect
Mhurchu [34] 2004 47 (11.7) / 48 (11.5) 116 / 118 New Zealand / overweight and obese Parallel 3 g/d 24 weeks Glucose Recruited using newspaper advertisements Decrease
Metso [40] 2003 46 (8) 90 / 93 Finland / hypercholesterolaemic Crossover 1.2 g/d 13 weeks Glucose Invitation letters No effect
Ho [43] 2001 43.3(7.7) / 42.6(6.7) 32/36 Singapore/Obesity Parallel 0.25 g/d 16 weeks Insulin Recruited from the general public by advertisement No effect
Jeong [37] 2019 28.6(1.49)/28.6(1.49) 19/19 Korea/prediabetes Crossover 0.25 g/d 2 weeks Glucose Recruited from the Clinical Nutrigenetics/Nutrigenomics Laboratory at Yonsei University Decrease