Table 3 Association between dietary flavonoids intake and CVD mortality

  No. of deaths

370

337

351

380

393

  Age-adjusted HR (95% CI) ^a

1

0.94 (0.81–1.09)

0.97 (0.84–1.12)

1.01 (0.87–1.16)

1.08 (0.94–1.25)

  Multivariate-adjusted HR (95% CI) ^b

1

0.96 (0.82–1.11)

0.97 (0.84–1.13)

1.02 (0.88–1.18)

1.06 (0.91–1.23)

   < 60 years

  HR (95% CI) ^b

1

1.05 (0.86–1.31)

0.96 (0.76–1.20)

1.00 (0.80–1.25)

1.22 (0.98–1.51)

   > 60 years

  HR (95% CI) ^b

1

0.86 (0.70–1.05)

0.91 (0.74–1.11)

0.94 (0.78–1.15)

0.79 (0.63–0.97)

   < 30

  HR (95% CI) ^b

1

0.97 (0.82–1.15)

0.95 (0.81–1.13)

0.98 (0.83–1.16)

1.03 (0.87–1.22)

   > 30

  HR (95% CI) ^b

1

0.84 (0.61–1.15)

0.93 (0.68–1.28)

0.98 (0.72–1.34)

0.86 (0.61–1.21)

  No. of deaths

174

145

147

182

187

  Age-adjusted HR (95% CI) ^a

1

0.85 (0.68–1.06)

0.85 (0.68–1.06)

0.83 (0.83–1.25)

0.88 (0.88–1.33)

  Multivariate-adjusted HR (95% CI) ^b

1

0.84 (0.67–1.05)

0.84 (0.67–1.05)

0.99 (0.80–1.23)

1.01 (0.83–1.26)

   < 60 years

  HR (95% CI) ^b

1

0.83 (0.62–1.12)

0.79 (0.59–1.07)

0.67 (0.49–0.91)

0.87 (0.66–1.15)

> 60 years

HR (95% CI) ^b

1

0.71 (0.52–0.99)

0.81 (0.59–1.10)

0.87 (0.64–1.17)

0.70 (0.51–0.98)

   < 30

  HR (95% CI) ^b

1

0.80 (0.62–1.04)

0.84 (0.65–1.08)

0.92 (0.72–1.17)

0.95 (0.74–1.21)

   > 30

  HR (95% CI) ^b

1

0.92 (0.58–1.44)

0.72 (0.44–1.19)

1.07 (0.68–1.68)

0.94 (0.58–1.53)

  No. of deaths

132

117

122

120

129

  Age-adjusted HR (95% CI) ^a

1

0.93 (0.72–1.19)

0.97 (0.76–1.24)

0.91 (0.71–1.16)

1.02 (0.80–1.30)

  Multivariate-adjusted HR (95% CI) ^b

1

0.98 (0.76–1.27)

1.01 (0.79–1.30)

0.95 (0.74–1.23)

1.05 (0.81–1.36)

   < 60 years

  HR (95% CI) ^b

1

1.26 (0.84–1.91)

1.18 (0.78–1.80)

1.02 (0.65–1.58)

1.42 (0.93–2.1)

   > 60 years

  HR (95% CI) ^b

1

0.83 (0.60–1.15)

0.86 (0.62–1.18)

0.86 (0.63–1.18)

0.79 (0.56–1.11)

   < 30

  HR (95% CI) ^b

1.05 (0.79–1.40)

1.02 (0.77–1.36)

0.89 (0.66–1.19)

1.02 (0.76–1.37)

   > 30

HR (95% CI) ^b

0.73 (0.41–1.27)

0.91 (0.53–1.56)

0.67 (0.67–1.87)

0.58 (0.58–1.77)

  No. of deaths

379

338

337

378

399

  Age-adjusted HR (95% CI) ^a

1

0.91 (0.79–1.06)

0.90 (0.78–1.04)

0.96 (0.83–1.11)

1.06 (0.92–1.22)

  Multivariate-adjusted HR (95% CI) ^b

1

0.93 (0.80–1.08)

0.91 (0.79–1.06)

0.98 (0.85–1.14)

1.05 (0.91–1.23)

   < 60 years

  HR (95% CI) ^b

1

1.03 (0.83–1.29)

0.92 (0.74–1.16)

0.99 (79–1.24)

1.22 (0.98–1.52)

   > 60 years

  HR (95% CI) ^b

1

0.82 (0.67–1.01)

0.85 (0.70–1.04)

0.90 (0.74–1.09)

0.78 (0.63–0.96)

   < 30

  HR (95% CI) ^b

1

0.97 (0.82–1.15)

0.87 (0.60–1.01)

0.96 (0.81–1.14)

1.02 (0.86–1.21)

   > 30

  HR (95% CI) ^b

1

0.75 (0.55–1.04)

1.00 (0.74–1.35)

0.87 (0.63–1.20)

0.88 (0.63–1.24)

  No. of deaths

177

142

145

182

189

  Age-adjusted HR (95% CI) ^a

1

0.81 (0.65–1.01)

0.82 (0.66–1.02)

0.99 (0.80–1.22)

1.07 (0.87–1.31)

  Multivariate-adjusted HR (95% CI) ^b

1

0.81 (0.65–1.01)

0.80 (0.64–1.00)

0.97 (0.81–1.25)

1.00 (0.81–1.25)

   < 60 years

  HR (95% CI) ^b

1

0.84 (0.61–1.15)

0.77 (0.56–1.06)

1.00 (0.74–1.35)

1.13 (0.84–1.53)

   > 60 years

  HR (95% CI) ^b

1

0.76 (0.55–1.04)

0.79 (0.58–1.08)

0.87 (0.64–1.18)

0.73 (0.52–1.02)

   < 30

  HR (95% CI) ^b

1

0.82 (0.63–1.05)

0.78 (0.60–1.01)

0.93 (0.73–1.19)

0.94 (0.73–1.20)

   > 30

  HR (95% CI) ^b

1

0.74 (0.46–1.18)

0.81 (0.51–1.29)

0.93 (0.58–1.47)

0.94 (0.58–1.53)

  No. of deaths

133

123

117

116

131

  Age-adjusted HR (95% CI) ^a

1

0.96 (0.75–1.23)

0.91 (0.71–1.17)

0.85 (0.66–1.09)

1.01 (0.79–1.29)

  Multivariate-adjusted HR (95% CI) ^b

1

1.02 (0.79–1.30)

0.97 (0.75–1.24)

0.90 (0.70–1.17)

1.07 (0.82–1.38)

   < 60 years

  HR (95% CI) ^b

1

1.47 (0.98–2.20)

1.02 (0.66–1.58)

1.03 (0.66–1.61)

1.48 (0.97–2.26)

   > 60 years

  HR (95% CI) ^b

1

0.78 (0.56–1.08)

0.89 (0.65–1.22)

0.79 (0.57–1.08)

0.78 (0.56–1.10)

   < 30

  HR (95% CI) ^b

1

1.10 (0.83–1.46)

0.94 (0.70–1.25)

0.86 (0.64–1.16)

1.04 (0.77–1.40)

   > 30

  HR (95% CI) ^b

1

0.71 (0.40–1.25)

1.05 (0.63–1.75)

0.98 (0.58–1.67)

1.02 (0.58–1.80)

  No. of deaths

371

330

353

384

393

  Age-adjusted HR (95% CI) ^a

1

0.90 (0.77–1.04)

0.98 (0.84–1.13)

0.99 (0/92–1.14)

1.06 (0.92–1.23)

  Multivariate-adjusted HR (95% CI) ^b

1

0.92 (0.79–1.07)

0.97 (0.83–1.12)

1.00 (0.86–1.15)

1.04 (0.89–1.21)

   < 60 years

  HR (95% CI) ^b

1

1.01 (0.81–1.26)

0.92 (0.73–1.15)

1.00 (0.80–1.25)

1.20 (0.97–1.48)

   > 60 years

  HR (95% CI) ^b

1

0.83 (0.67–1.02)

0.93 (0.76–1.13)

0.92 (0.75–1.12)

0.76 (0.62–0.95)

   < 30

  HR (95% CI) ^b

1

0.95 (0.81–1.13)

0.95 (0.80–1.13)

0.97 (0.82–1.14)

1.01 (0.85–1.20)

   > 30

  HR (95% CI) ^b

1

0.75 (0.54–1.03)

0.92 (0.67–1.25)

0.95 (0.69–1.29)

0.84 (0.60–1.17)

  No. of deaths

177

137

153

179

189

  Age-adjusted HR (95% CI) ^a

1

0.77 (0.62–0.97)

0.88 (0.70–1/09)

0.96 (0.78–1.19)

1.06 (0.86–1.31)

  Multivariate-adjusted HR (95% CI) ^b

1

0.77 (0.61–0.96)

0.86 (0.69–1.07)

0.94 (0.76–1.16)

0.99 (0.80–1.23)

   < 60 years

  HR (95% CI) ^b

1

0.89 (0.65–1.22)

0.78 (0.57–1.08)

1.04 (0.77–1.41)

1.18 (0.88–1.58)

   > 60 years

  HR (95% CI) ^b

1

0.66 (0.46–0.89)

0.87 (0.64–1.17)

0.79 (0.58–1.06)

0.69 (0.49–0.95)

   < 30

  HR (95% CI) ^b

1

0.76 (0.59–0.99)

0.87 (0.68–1.12)

0.87 (0.68–1.11)

0.93 (0.73–1.19)

   > 30

  HR (95% CI) ^b

1

0.74 (0.46–1.17)

0.70 (0.43–1.14)

1.04 (0.67–1.61)

0.91 (0.57–1.47)

  No. of deaths

129

119

122

123

127

  Age-adjusted HR (95% CI) ^a

1

0.94 (0.73–1.21)

1.00 (0.78–1.28)

0.92 (0.72–1.18)

1.00 (0.79–1.29)

  Multivariate-adjusted HR (95% CI) ^b

1

1.01 (0.78–1.29)

1.01 (0.78–1.30)

0.97 (0.75–1.25)

1.03 (0.80–1.34)

   < 60 years

  HR (95% CI) ^b

1

1.35 (090–2.05)

1.18 (0.77–1.81)

1.06 (0.68–1.66)

1.42 (0.93–2.16)

   > 60 years

  HR (95% CI) ^b

1

0.83 (0.60–1.15)

0.86 (0.63–1.19)

0.86 (0.63–1.18)

0.77 (0.55–1.08)

   < 30

  HR (95% CI) ^b

1

1.09 (0.82–1.45)

1.01 (0.76–1.35)

0.94 (0.70–1.26)

1.01 (0.75–1.36)

   > 30

  HR (95% CI) ^b

1

0.71 (0.41–1.24)

0.96 (0.57–1.62)

1.00 (0.59–1.69)

0.97 (0.56–1.69)

  No. of deaths

460

388

333

328

322

  Age-adjusted HR (95% CI) ^a

1

0.92 (0.80–1.05)

0.82 (0.71–1.05)

0.82 (0.71–0.94)

0.82 (0.71–0.95)

  Multivariate-adjusted HR (95% CI) ^b

1

0.90 (0.78–1.03)

0.82 (0.71–0.94)

0.83 (0.72–0.86)

0.86 (0.73–1.00)

   < 60 years

  HR (95% CI) ^b

1

0.87 (0.71–1.11)

0.85 (0.69–1.05)

0.75 (0.60–0.94)

0.84 (0.67–1.05)

   > 60 years

  HR (95% CI) ^b

1

0.92 (0.76–1.11)

0.77 (0.63–0.95)

0.98 (0.80–1.20)

0.94 (0.76–1.17)

   < 30

  HR (95% CI) ^b

1

0.87 (0.74–1.01)

0.79 (0.68–0.93)

0.82 (0.70–0.97)

0.86 (0.72–1.03)

  > 30

HR (95% CI) ^b

1

1.08 (0.77–1.52)

0.89 (0.63–1.26)

0.94 (0.67–1.32)

0.93 (0.66–1.32)

  No. of deaths

195

176

161

143

160

  Age-adjusted HR (95% CI) ^a

1

0.97 (0.79–1.19)

0.92 (0.74–1.13)

0.84 (0.67–1.04)

0.95 (0.77–1.17)

  Multivariate-adjusted HR (95% CI) ^b

1

0.95 (0.77–1.16)

0.88 (0.71–1.10)

0.82 (0.65–1.02)

0.92 (0.73–1.16)

   < 60 years

  HR (95% CI) ^b

1

0.94 (0.70–1.27)

1.02 (0.76–1.37)

0.81 (0.59–1.12)

1.05 (0.77–1.43)

   > 60 years

  HR (95% CI) ^b

1

0.97 (0.72–1.29)

0.76 (0.55–1.05)

0.89 (0.65–1.22)

0.86 (0.61–1.20)

   < 30

  HR (95% CI) ^b

1

0.98 (0.78–1.23)

0.89 (0.70–1.13)

0.91 (0.71–1.16)

0.98 (0.75–1.26)

   > 30

  HR (95% CI) ^b

1

0.82 (0.50–1.35)

0.86 (0.53–1.37)

0.56 (0.34–0.94)

0.78 (0.48–1.27)

  No. of deaths

158

139

109

115

99

  Age-adjusted HR (95% CI) ^a

1

0.98 (0.78–1.23)

0.80 (0.63–1.03)

0.86 (0.68–1.10)

0.76 (0.58–0.98)

  Multivariate-adjusted HR (95% CI) ^b

1

0.94 (0.74–1.18)

0.78 (0.61–1.00)

0.87 (0.68–1.11)

0.80 (0.61–1.06)

   < 60 years

  HR (95% CI) ^b

1

0.72 (0.49–1.05)

0.67 (0.45–0.99)

0.79 (0.54–1.16)

0.68 (0.44–1.04)

   > 60 years

  HR (95% CI) ^b

1

1.10 (0.82–1.48)

0.88 (0.63–1.21)

0.98 (0.70–1.36)

0.96 (0.68–1.36)

   < 30

  HR (95% CI) ^b

1

0.84 (0.65–1.08)

0.76 (0.58–1.00)

0.76 (0.57–1.01)

0.74 (0.55–1.01)

   > 30

  HR (95% CI) ^b

1

1.80 (0.98–3.31)

1.09 (0.56–2.13)

1.69 (0.92–3.08)

1.37 (0.72–2.59)

  No. of deaths

466

359

349

332

325

  Age-adjusted HR (95% CI) ^a

1

0.84 (0.73–0.97)

0.86 (0.75–0.99)

0.82 (0.71–0.94)

0.81 (0.70–0.93)

  Multivariate-adjusted HR (95% CI) ^b

1

0.87 (0.76–1.00)

0.89 (0.77–1.03)

0.84 (0.72–0.98)

0.85 (0.72–1.00)

   < 60 years

  HR (95% CI) ^b

1

0.76 (0.61–0.94)

0.82 (0.66–1.01)

0.87 (0.70–1.08)

0.82 (0.65–1.03)

   > 60 years

  HR (95% CI) ^b

1

0.95 (0.79–1.14)

0.95 (0.78–1.16)

0.80 (0.64–0.99)

0.92 (0.73–1.14)

   < 30

  HR (95% CI) ^b

1

0.89 (0.76–1.04)

0.85 (0.81–1.12)

0.88 (0.74–1.04)

0.86 (0.72–1.03)

   > 30

  HR (95% CI) ^b

1

0.79 (0.57–1.10)

0.70 (0.50–0.99)

0.75 (0.53–1.04)

0.83 (0.59–1.15)

  No. of deaths

186

160

159

171

159

  Age-adjusted HR (95% CI) ^a

1

0.93 (0.75–1.15)

0.97 (0.78–1.19)

1.03 (0.84–1.28)

0.97 (0.78–1.20)

  Multivariate-adjusted HR (95% CI) ^b

1

0.96 (0.77–1.19)

0.97 (0.77–1.21)

1.04 (0.83–1.29)

0.97 (0.76–1.23)

   < 60 years

  HR (95% CI) ^b

1

0.84 (0.61–1.14)

0.86 (0.63–1.17)

1.05 (0.77–1.42)

0.95 (0.68–1.31)

   > 60 years

  HR (95% CI) ^b

1

1.06 (0.79–1.44)

1.11 (0.81–1.52)

1.00 (0.71–1.39)

1.02 (0.72–1.46)

   < 30

  HR (95% CI) ^b

1

0.90 (0.71–1.15)

0.99 (0.78–1.24)

1.09 (0.85–1.39)

0.82 (0.71–1.22)

   > 30

  HR (95% CI) ^b

1

1.22 (0.75–1.99)

0.93 (0.55–1.57)

0.91 (0.54–1.54)

1.15 (0.69–1.91)

  No. of deaths

171

127

121

101

100

  Age-adjusted HR (95% CI) ^a

1

0.83 (0.66–1.05)

0.85 (0.67–1.08)

0.71 (0.55–0.91)

0.70 (0.55–0.90)

  Multivariate-adjusted HR (95% CI) ^b

1

0.84 (0.67–1.07)

0.86 (0.67–1.10)

0.71 (0.55–0.93)

0.74 (0.56–0.98)

   < 60 years

  HR (95% CI) ^b

1

0.63 (0.42–0.94)

0.77 (0.52–1.13)

0.66 (0.44–0.99)

0.63 (0.41–0.98)

   > 60 years

  HR (95% CI) ^b

1

0.97 (0.72–1.30)

0.90 (0.66–1.24)

0.74 (0.52–1.05)

0.84 (0.59–1.21)

   < 30

  HR (95% CI) ^b

1

0.92 (0.71–1.20)

0.96 (0.73–1.26)

0.75 (0.56–1.02)

0.74 (0.54–1.03)

   > 30

  HR (95% CI) ^b

1

0.58 (0.33–1.01)

0.59 (0.34–1.03)

0.60 (0.34–1.04)

0.70 (0.40–1.20)

  No. of deaths

438

396

350

326

321

  Age-adjusted HR (95% CI) ^a

1

0.96 (0.84–1.10)

0.89 (0.77–1.03)

0.88 (0.76–1.01)

0.89 (0.77–1.03)

  Multivariate-adjusted HR (95% CI) ^b

1

0.96 (0.84–1.10)

0.91 (0.79–1.05)

0.91 (0.79–1.06)

0.96 (0.82–1.11)

   < 60 years

  HR (95% CI) ^b

1

1.06 (0.87–1.31)

0.96 (0.77–1.19)

0.90 (0.72–1.12)

0.95 (0.76–1.19)

   > 60 years

  HR (95% CI) ^b

1

0.86 (0.72–1.04)

0.86 (0.71–1.05)

0.95 (0.77–1.16)

0.95 (0.77–1.16)

   < 30

  HR (95% CI) ^b

1

0.89 (0.77–1.04)

0.88 (0.75–1.04)

0.90 (0.77–1.07)

0.94 (0.80–1.12)

   > 30

  HR (95% CI) ^b

1

1.27 (0.92–1.74)

1.05 (0.76–1.46)

0.98 (0.70–1.37)

1.03 (0.72–1.47)

  No. of deaths

186

179

174

155

141

  Age-adjusted HR (95% CI) ^a

1

1.01 (0.82–1.24)

1.03 (0.83–1.27)

0.96 (0.78–1.19)

0.90 (0.72–1.12)

  Multivariate-adjusted HR (95% CI) ^b

1

1.00 (0.81–1.23)

1.02 (0.82–1.26)

0.95 (0.76–1.19)

0.90 (0.72–1.13)

   < 60 years

  HR (95% CI) ^b

1

1.08 (0.81–1.45)

1.01 (0.74–1.36)

0.88 (0.65–1.21)

0.94 (0.69–1.29)

   > 60 years

  HR (95% CI) ^b

1

0.90 (0.67–1.22)

1.02 (0.75–1.38)

1.05 (0.76–1.43)

0.82 (0.59–1.16)

   < 30

  HR (95% CI) ^b

1

0.96 (0.76–1.21)

1.01 (0.80–1.28)

0.93 (0.73–1.20)

0.87 (0.68–1.13)

   > 30

  HR (95% CI) ^b

1

1.20 (0.74–1.94)

1.09 (0.67–1.78)

1.05 (0.65–1.72)

1.03 (0.60–1.73)

  No. of deaths

155

144

104

105

112

  Age-adjusted HR (95% CI) ^a

1

1.01 (0.80–1.27)

0.77 (0.60–0.99)

0.83 (0.65–1.06)

0.92 (0.72–1.18)

  Multivariate-adjusted HR (95% CI) ^b

1

0.99 (0.79–1.25)

0.78 (0.61–1.01)

0.88 (0.68–1.14)

1.04 (0.81–1.34)

   < 60 years

  HR (95% CI) ^b

1

1.22 (0.83–1.80)

1.03 (0.68–1.50)

1.04 (0.69–1.57)

0.96 (0.62–1.48)

   > 60 years

  HR (95% CI) ^b

1

0.87 (0.65–1.17)

0.65 (0.47–0.91)

0.80 (0.58–1.12)

1.10 (0.81–1.51)

   < 30

  HR (95% CI) ^b

1

0.87 (0.67–1.13)

0.75 (0.56–1.00)

0.84 (0.63–1.12)

1.00 (0.76–1.33)

   > 30

  HR (95% CI) ^b

1

1.69 (1.00–2.86)

1.01 (0.56–1.82)

1.18 (0.66–2.10)

1.31 (0.71–2.44)

  No. of deaths

403

326

350

362

390

  Age-adjusted HR (95% CI) ^a

1

0.85 (0.73–0.98)

0.90 (0.78–1.04)

0.91 (0.79–1.05)

1.02 (0.88–1.17)

  Multivariate-adjusted HR (95% CI) ^b

1

0.86 (0.75–1.00)

0.92 (0.79–1.06)

0.92 (0.79–1.06)

1.01 (0.87–1.17)

   < 60 years

  HR (95% CI) ^b

1

0.90 (0.73–1.11)

0.76 (0.61–0.94)

0.79 (0.64–0.97)

0.76 (0.62–0.93)

   > 60 years

  HR (95% CI) ^b

1

0.84 (0.68–1.02)

0.89 (0.73–1.09)

0.89 (0.73–1.08)

0.77 (0.62–0.95)

   < 30

  HR (95% CI) ^b

1

0.89 (0.75–1.05)

0.91 (0.77–1.07)

0.87 (0.74–1.03)

0.99 (0.84–1.17)

   > 30

  HR (95% CI) ^b

1

0.74 (0.53–1.01)

0.86 (0.63–1.17)

0.93 (0.68–1.27)

0.79 (0.56–1.10)

  No. of deaths

192

133

159

169

182

  Age-adjusted HR (95% CI) ^a

1

0.72 (0.57–0.89)

0.85 (0.69–1.05)

0.88 (0.72–1.09)

0.98 (0.80–1.20)

  Multivariate-adjusted HR (95% CI) ^b

1

0.71 (0.57–0.89)

0.83 (0.67–1.03)

0.85 (0.69–1.05)

0.92 (0.74–1.14)

   < 60 years

  HR (95% CI) ^b

1

0.72 (0.53–0.99)

0.82 (0.60–1.11)

0.90 (0.67–1.22)

1.02 (0.76–1.37)

   > 60 years

  HR (95% CI) ^b

1

0.66 (0.48–0.92)

0.80 (0.59–1.09)

0.72 (0.53–0.98)

0.68 (0.49–0.94)

   < 30

  HR (95% CI) ^b

1

0.72 (0.56–0.93)

0.85 (0.67–1.09)

0.79 (0.62–1.01)

0.86 (0.67–1.09)

   > 30

  HR (95% CI) ^b

1

0.65 (0.40–1.04)

0.68 (0.42–1.09)

0.94 (0.60–1.47)

0.87 (0.55–1.40)

  No. of deaths

142

120

115

113

130

  Age-adjusted HR (95% CI) ^a

1

0.91 (0.71–1.16)

0.86 (0.67–1.11)

0.83 (0.64–1.16)

0.99 (0.78–1.26)

  Multivariate-adjusted HR (95% CI) ^b

1

0.96 (0.75–1.22)

0.91 (0.71–1.17)

0.86 (0.66–1.11)

1.-04 (0.81–1.34)

   < 60 years

  HR (95% CI) ^b

1

1.02 (0.69–1.50)

0.89 (0.59–1.34)

0.71 (0.45–1.10)

1.21 (0.81–1.80)

   > 60 years

  HR (95% CI) ^b

1

0.88 (0.64–1.21)

0.87 (0.63–1.19)

0.88 (0.64–1.21)

0.83 (0.59–1.17)

   < 30

  HR (95% CI) ^b

1

1.04 (0.79–1.37)

0.88 (0.66–1.17)

0.78 (0.58–1.05)

1.04 (0.78–1.39)

   > 30

  HR (95% CI) ^b

1

0.64 (0.36–1.14)

0.98 (0.59–1.64)

1.08 (0.65–1.80)

0.89 (0.51–1.56)

  No. of deaths

374

381

314

  Age-adjusted HR (95% CI) ^a

1.01 (0.89–1.14)

1.00 (0.88–1.13)

0.83 (0.73–0.95)

  Multivariate-adjusted HR (95% CI) ^b

1.01 (0.89–1.14)

0.83 (0.73–0.95)

0.86 (0.75–0.99)

   < 60 years

  HR (95% CI) ^b

0.95 (0.79–1.14)

1.08 (0.90–1.29)

0.96 (0.80–1.17)

   > 60 years

  HR (95% CI) ^b

1.05 (0.88–1.24)

0.99 (0.83–1.18)

0.81 (0.67–0.98)

   < 30

  HR (95% CI) ^b

1.04 (0.91–1.20)

1.05 (0.91–1.20)

0.87 (0.74–1.02)

   > 30

  HR (95% CI) ^b

0.82 (0.61–1.10)

0.91 (0.69–1.20)

0.79 (0.60–1.04)

  No. of deaths

159

187

154

  Age-adjusted HR (95% CI) ^a

0.97 (0.93–1.33)

1.11 (0.93–1.33)

0.93 (0.77–1.12)

  Multivariate-adjusted HR (95% CI) ^b

0.96 (0.80–1.17)

1.11 (0.92–1.33)

0.93 (0.76–1.13)

   < 60 years

  HR (95% CI) ^b

0.95 (0.72–1.23)

1.16 (0.90–1.49)

1.09 (0.84–1.42)

   > 60 years

  HR (95% CI) ^b

0.98 (0.74–1.28)

1.11 (0.85–1.45)

0.79 (0.58–1.07)

   < 30

  HR (95% CI) ^b

1.03 (0.84–1.27)

1.16 (0.95–1.42)

0.88 (0.70–1.10)

   > 30

  HR (95% CI) ^b

0.67 (0.42–1.07)

0.96 (0.64–1.44)

1.02 (0.69–1.49)

  No. of deaths

139

130

91

  Age-adjusted HR (95% CI) ^a

0.99 (0.80–1.23)

0.97 (0.78–1.19)

0.68 (0.54–0.87)

  Multivariate-adjusted HR (95% CI) ^b

0.98 (0.79–1.21)

0.96 (0.78–1.19)

0.71 (0.56–0.91)

   < 60 years

  HR (95% CI) ^b

0.81 (0.57–1.16)

1.14 (0.83–1.57)

0.76 (0.52–1.12)

   > 60 years

  HR (95% CI) ^b

1.09 (0.84–1.42)

0.88 (0.66–1.17)

0.71 (0.52–0.98)

   < 30

  HR (95% CI) ^b

0.88 (0.71–1.00)

0.95 (0.75–1.21)

0.70 (0.53–0.93)

   > 30

  HR (95% CI) ^b

1.38 (0.88–1.53)

1.10 (0.69–1.76)

0.76 (0.45–1.27)