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Table 2 Regression coefficients (95% CI) for cognitive function by quartiles of iron related dietary pattern among Chinese adults aged ≥55 years old attending China Health and Nutrition Survey (N = 4852) between 1997 and 2006

From: Iron-related dietary pattern increases the risk of poor cognition

 

Dietary pattern quartiles

 

Q1 (low intake)

Q2

Q3

Q4 (high intake)

p for trend

Global cognitive function

Coef. (95% CI)

 

 Model 1a

0.00

−0.06 (−0.42–0.30)

−0.53 (−0.92--0.15)

−1.23 (−1.65--0.81)

< 0.001

 Model 2b

0.00

0.00 (− 0.39–0.38)

− 0.32 (− 0.73–0.08)

− 0.74 (−1.19--0.28)

< 0.001

 Model 3c

0.00

− 0.11 (− 0.50–0.28)

− 0.42 (− 0.84–0.00)

− 0.79 (− 1.25--0.32)

< 0.001

Model 3+ carbohydrate (quartiles)

0.00

0.15 (− 0.26–0.55)

0.05 (− 0.40–0.50)

− 0.19 (− 0.70–0.32)

0.373

Model 3 + lead (quartiles)

0.00

−0.01 (− 0.45–0.42)

−0.24 (− 0.74–0.27)

−0.57 (− 1.16–0.02)

0.035

Model 3 + iron (quartiles)

0.00

0.05 (−0.37–0.47)

−0.16 (− 0.63–0.31)

−0.41 (− 0.95–0.13)

0.080

Sensitivity analysis d

0.00

0.01 (− 0.36–0.38)

−0.30 (− 0.69–0.09)

−0.52 (− 0.96--0.09)

0.006

Verbal memory score

 Model 1a

0.00

−0.13 (− 0.38–0.13)

−0.44 (− 0.71--0.17)

−0.71 (− 1.00--0.41)

< 0.001

 Model 2b

0.00

−0.09 (− 0.37–0.18)

−0.25 (− 0.55–0.04)

−0.33 (− 0.66--0.01)

0.026

 Model 3c

0.00

−0.15 (− 0.43–0.13)

−0.31 (− 0.61--0.02)

−0.37 (− 0.70--0.04)

0.020

Model 3+ carbohydrate (quartiles)

0.00

0.01 (−0.29–0.30)

− 0.07 (− 0.39–0.26)

−0.10 (− 0.47–0.26)

0.509

Model 3 + lead (quartiles)

0.00

−0.09 (− 0.41–0.22)

−0.17 (− 0.54–0.19)

−0.19 (− 0.61–0.24)

0.376

Model 3 + iron (quartiles)

0.00

−0.01 (− 0.31–0.29)

−0.09 (− 0.42–0.25)

−0.06 (− 0.45–0.33)

0.688

Sensitivity analysisd

0.00

−0.10 (− 0.38–0.17)

−0.23 (− 0.52–0.06)

−0.22 (− 0.55–0.10)

0.131

  1. Regression coefficients and 95% CI were estimated with mixed effect regression models with different levels of adjustment
  2. a Model 1 adjusted for age, gender and energy intake
  3. b Model 2 further adjusted for intake of fat, smoking, alcohol drinking, income, urbanicity, education, and physical activity
  4. c Model 3 further adjusted for BMI and hypertension
  5. d Sensitivity analysis model 3 further adjusted for diabetes and stroke after excluding those with a global cognitive function score ≤ 4
  6. All the adjusted variables are treated as time-varying covariates. Bold font represents p<0.05