Placebo | Nutraceutical | Difference of changes between arms | |||
---|---|---|---|---|---|
Baseline | 12 weeks | Baseline | 12 weeks | P-value | |
Weight (kg) | 65 (64, 79) | 66 (63, 80) | 63 (59, 75) | 64 (58, 74) | 0.57 |
BMI (kg/m2) | 24 (21, 27) | 24 (21, 27) | 24 (22, 27) | 24 (22, 27) | 0.72 |
WC (cm) | 88 (84, 94) | 87 (82, 91) | 86 (83, 94) | 91 (82, 96) | 0.74 |
BIA (%) | 31 (26, 41) | 31 (27, 40) | 32 (27, 37) | 30 (26, 38) | 0.12 |
VFR (%) | 10 (7, 12) | 11 (8, 13) | 11 (8, 12) | 11 (8, 12) | 0.83 |
SBP (mmHg) | 125 (110, 130) | 120 (110, 128) | 120 (120, 130) | 120 (115, 130) | 0.95 |
DBP (mmHg) | 80 (80, 80) | 80 (70, 80) | 80 (80, 80) | 80 (80, 83) | 0.46 |
HR (bpm) | 65 (64, 68) | 64 (60, 67) | 64 (60, 68) | 65 (62, 71) | 0.23 |
TC (mg/mL) | 271 (256, 289) | 267 (259, 293) | 271 (239, 285) | 208 (201, 263) | <.0001 |
LDL-C (mg/mL) | 189 (174, 198) | 183 (171, 202) | 177 (167, 193) | 136.5 (118, 151.5) | <.0001 |
HDL-C (mg/mL) | 56 (48, 65) | 58.5 (50, 68) | 71 (43, 81) | 71 (48, 88) | 0.97 |
Non-HDL-C (mg/mL) | 215 (198, 232) | 217 (199, 232) | 206 (189, 214) | 198 (182, 208) | <.0001 |
TG (mg/mL) | 113 (94, 127) | 112 (99, 148) | 127 (93, 156) | 106 (80, 124) | 0.66 |
apoAI (mg/dL) | 113.5 (97.5, 126.5) | 110 (94.5, 120) | 128 (93, 139) | 128 (100, 151) | 0.24 |
apoB (mg/dL) | 143.5 (134, 148) | 135 (133, 151) | 155 (137, 158) | 118 (112, 131) | 0.003 |
oxLDL (U/L) | 71.2 (66.7, 84.0) | 76.4 (71.1, 99.5) | 78.3 (74.6, 129.0) | 81.0 (64.5, 114.1) | 0.014 |
Lp(a) (mg/dL) | 4.5 (2, 15.5) | 4 (2, 17.5) | 7 (4.5, 12) | 9 (4, 14.5) | 0.20 |
PCSK9 (ng/dL) | 341 (294, 375) | 324 (259, 360) | 341 (294, 375) | 346 (302, 366) | 0.38 |
FPG (mg/dL) | 95 (90, 97) | 93 (87, 101) | 93 (89, 101) | 95 (92, 103) | 0.20 |
Insulin (mUI/L) | 3.23 (2.64, 5.24) | 3.04 (2.31, 6.51) | 3.38 (2.24, 4.92) | 3.01 (2.38, 5.12) | 0.78 |
HOMA-IR | 0.73 (0.59, 1.23) | 0.69 (0.51, 1.64) | 0.77 (0.52, 1.15) | 0.77 (0.49, 1.24) | 0.92 |
FGF19 (pg/mL) | 233 (166, 337) | 261 (164, 305) | 218 (177, 299) | 221 (183, 374) | 0.98 |
FGF21 (pg/mL) | 185 (72, 227) | 148 (77, 263) | 179 (158, 364) | 161 (66, 309) | 0.11 |