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Table 4 Male:female rate ratio of NTDs by folic acid supplementation in northern China, 1993–1995

From: Periconceptional folic acid supplementation and sex difference in prevention of neural tube defects and their subtypes in China: results from a large prospective cohort study

Folic acid N Open NTDs Anencephaly Spina bifida Encephalocele Total NTDs
RR 95% CI RR 95% CI RR 95% CI RR 95% CI RR 95% CI
Yes 18,201 1.00 0.69–1.46 0.46 0.02–8.62 1.14 0.73–1.77 1.82 0.10–34.48 1.08 0.77–1.50
No 12,664 0.43 0.39–0.49 0.33 0.26–0.42 0.58 0.46–0.72 2.71 0.20–37.04 0.48 0.43–0.53
Total 30,801 0.53 0.48–0.57 0.34 0.27–0.43 0.73 0.63–0.84 2.27 0.58–8.59 0.58 0.54–0.63
  1. NTD neural tube defect, RR rate ratio, 95%CI, 95% confidence interval