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Table 1 Characteristics of 16 randomized controlled trials included in analysisa

From: Lack of efficacy of pomegranate supplementation for glucose management, insulin levels and sensitivity: evidence from a systematic review and meta-analysis

Author, publication year

Sample Size

Study design

Details of participants selection

Sex (M/F)

Age (years)b

BMI (kg/m2)b

Intervention group

Control group

Duration (weeks)

Location

FBG at baseline (T vs. C)b

Outcomes of measures

Sumner, 2005

45

R, DB, P

Patients with coronary heart disease

40/5

69.0 ± 10.0

28.5 ± 5.6

PJ consumption; 240 ml/day

Placebo (modified sports beverage)

12

USA

T: 113.0 ± 30.0

C: 116.0 ± 51.0

FBG, HbA1C

Cerda, 2006

30

R, DB, P

Patients with stable chronic obstructive pulmonary disease

NA

61.7 ± 10.0

31.0 ± 5.4

PJ consumption; 400 ml/day

Placebo

5

Spain

T: 114.5 ± 25.5

C: 113.7 ± 51.5

FBG,

Heber, 2007a

42

R, DB, P

Overweight individuals with increased waist size

NA

40–70

33.5 ± 8.5

PE extract; 710 mg/day

Placebo

4

USA

T1: 95.3 ± 10.4

T2: 89.2 ± 7.6

FBG,

Heber, 2007b

41

R, DB, P

Overweight individuals with increased waist size

NA

40–70

33.5 ± 8.5

PE extract; 1420 mg/day

Placebo

4

USA

T: 89.2 ± 7.6

C: 97.8 ± 9.0

FBG,

Mirmiran, 2010

45

R, DB, P

Subjects with hyperlipidaemic

NA

53.0 ± 9.0

27.7 ± 3.4

PSO consumption; 400 mg/day

Placebo

4

Iran

NA

FBI, HOMA-IR

González-Ortiz, 2011

20

R, DB, P

Patients with obesity

NA

37.3 ± 9.5

34.5 ± 3.7

PJ consumption; 120 ml/day

Placebo

4

Mexico

T: 84.6 ± 5.4

C: 84.6 ± 9.0

FBG, FBI

Tsang, 2012

28

R, DB, C

Healthy volunteers

12/16

50.4 ± 6.1

26.8 ± 3.4

PJ consumption; 500 ml/day

Placebo (water plus the equivalent carbohydrates)

4

UK

T: 88.0 ± 6.7

C: 83.7 ± 8.6

FBG, FBI, HOMA-IR

Asgary, 2014

21

R, SB, P

Subjects with hypertension

6/15

52.9 ± 10.8

27.4 ± 3.8

PJ consumption; 150 ml/day

Placebo (water)

2

Iran

T: 90.1 ± 6.1

C: 87.8 ± 10.9

FBG, FBI

Park, 2014

77

R, DB, P

Overweight women

0/77

41.5 ± 12.5

28.4 ± 2.2

PJ consumption; 200 ml/day

Placebo (beverage)

8

Korea

T: 98.5 ± 8.2

C: 97.1 ± 9.4

FBG, FBI, HOMA-IR

Sohrab, 2014

44

R, DB, P

Patients with T2DM

NA

55.9 ± 6.7

29.0 ± 4.0

PJ consumption; 250 ml/day

Placebo

12

Iran

T: 160.3 ± 47.8

C: 148.7 ± 42.1

FBG, FBI, HOMA-IR, HbA1C

Hosseini, 2016

42

R, DB, P

Overweight and obese individuals

NA

30–60

31.8 ± 4.5

PE supplementation; 1000 mg/day

Placebo

4

Australia

T: 98.6 ± 10.4

C: 99.6 ± 14.9

FBG, FBI, HOMA-IR

Faghihimani, 2016

74

R, DB, P

Patients with T2DM

26/52

50.0 ± 6.8

26.5 ± 2.6

PSO capsules consumption; 2000 mg/day

Placebo(medium chain triacylglycerol)

8

Iran

T: 149.0 ± 39.0

C: 156.0 ± 56.0

FBG, FBI, HOMA-IR, HbA1C

Sohrab, 2016

60

R, SB, P

Patients with T2DM

NA

54.7 ± 8.4

27.3 ± 3.7

PJ consumption; 200 ml/day

Placebo

6

Iran

T: 158.1 ± 41.1

C: 193.0 ± 63.3

FBG,

Fuster-Munoz, 2016a

14

R, DB, P

Endurance-based athletes

14/0

35.3 ± 8.8

NA

PJ consumption; 200 ml/day

seasonal fruit

3

Spain

T: 79.0 ± 8.0

C: 74.4 ± 9.5

FBG,

Fuster-Munoz, 2016b

14

R, DB, P

Endurance-based athletes

14/0

35.3 ± 10.4

NA

PJ diluted 1:1 with water consumption; 200 ml/day

seasonal fruit

3

Spain

T: 73.3 ± 8.0

C: 74.4 ± 9.5

FBG,

Moazzen, 2017

30

R, DB, C

Patients with metabolic syndrome

13/17

51.57 ± 10.0

NA

PJ consumption; 500 ml/day

Placebo

1

Iran

T: 144.6 ± 11.9

C: 144.7 ± 12.3

FBG, FBI, HOMA-IR

  1. a R randomized, DB double-blind, SB single-blind, C crossover, P paralle, F female, M male, NA not available, BMI body mass index, PE pomegranate ellagitannin, PJ pomegranate juice, PSO pomegranate seed oil, T Treatment group, T2DM type 2 diabetes mellitus, C control group, FBG fasting blood glucose, FBI fasting blood insulin, HbA1c glycated hemoglobin, HOMA-IR homeostatic model assessment of insulin resistance
  2. bValues are provided as mean ± SD, except the studies conducted by Heber et al. and Hosseini et al. The values in these studies were