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Table 6 Effects of lactose malabsorption on gastrointestinal symptoms

From: Effects of cow’s milk beta-casein variants on symptoms of milk intolerance in Chinese adults: a multicentre, randomised controlled study

1 h Absorbers (n=170) Malabsorbers (n=430)
  A1 A2 GEE estimate A1 A2 GEE estimate
  Median Range Median Range Estimate SE P Median Range Median Range Estimate SE P
Borborygmus 3 0–6 2 0–6 1.562 0.218 <0.0001 3 0–6 2 0–5 1.244 0.116 <0.0001
Flatulence 3 0–6 2 0–5 1.826 0.212 <0.0001 2 0–6 1 0–5 1.395 0.119 <0.0001
Bloating 2 0–6 1 0–5 1.698 0.201 <0.0001 2 0–6 1 0–6 1.406 0.12 <0.0001
Abdominal Pain 1 0–5 0 0–4 1.552 0.206 <0.0001 0 0–5 0 0–5 0.396 0.107 0.0002
Stool Frequency 1 0–5 0 0–4 1.328 0.212 <0.0001 0 0–5 0 0–3 0.518 0.121 <0.0001
Stool Consistency 1 0–5 0 0–4 1.339 0.207 <0.0001 0 0–5 0 0–4 0.566 0.128 <0.0001
3 h Absorbers (n=170) Malabsorbers (n=430)
  A1 A2 GEE estimate A1 A2 GEE estimate
  Median Range Median Range Estimate SE P Median Range Median Range Estimate SE P
Borborygmus 3 0–5 2 0–5 1.701 0.206 <0.0001 3 0–6 2 0–6 2.022 0.124 <0.0001
Flatulence 3 0–5 2 0–5 1.424 0.199 <0.0001 3 0–6 2 0–5 2.079 0.133 <0.0001
Bloating 3 0–5 2 0–5 1.617 0.196 <0.0001 3 0–6 2 0–4 2.066 0.125 <0.0001
Abdominal Pain 2 0–6 0 0–4 1.375 0.204 <0.0001 2 0–6 0 0–4 2.149 0.134 <0.0001
Stool Frequency 1 0–5 0 0–3 1.866 0.222 <0.0001 2 0–5 0 0–3 2.454 0.136 <0.0001
Stool Consistency 1 0–5 0 0–4 1.904 0.216 <0.0001 2 0–5 0 0–3 2.586 0.146 <0.0001
12 ha Absorbers (n=117) Malabsorbers (n=283)
  A1 A2 GEE estimate A1 A2 GEE estimate
  Median Range Median Range Estimate SE P Median Range Median Range Estimate SE P
Borborygmus 0 0–2 0 0–2 –0.479 0.375 0.202 0 0–2 0 0–2 0.317 0.211 0.133
Flatulence 1 0–3 0 0–3 0.165 0.251 0.509 0 0–3 0 0–2 0.297 0.159 0.062
Bloating 2 0–4 1 0–4 1.074 0.242 <0.0001 2 0–5 1 0–4 0.812 0.15 <0.0001
Abdominal Pain 2 0–3 1 0–3 2.239 0.253 <0.0001 2 0–5 1 0–3 1.793 0.156 <0.0001
Stool Frequency 1 0–3 0 0–2 1.618 0.282 <0.0001 1 0–2 0 0–2 1.854 0.192 <0.0001
Stool Consistency 1 0–2 0 0–1 1.988 0.291 <0.0001 1 0–3 0 0–2 2.077 0.183 <0.0001
  1. A1 conventional milk containing A1 and A2 β-casein, A2 milk containing A2 β-casein
  2. aThe VAS was not assessed at 12 h in Shanghai