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Table 2 Results of vitamin D treatment on biochemical parameters in patients with advanced chronic heart failure (NYHA functional class ≥ II)

From: Randomized supplementation of 4000 IU vitamin D3 daily vs placebo on the prevalence of anemia in advanced heart failure: the EVITA trial

Characteristics Vitamin D group (n = 85) Placebo group (n = 87)
Baseline Follow-up (36- month) Mean change from baselinea Baseline Follow-up (36- month) Mean change from baselinea Mean change difference between groupsa P-valueb
Vitamin D metabolites
 25OHD (nmol/l) 30.7 (22.0–46.6) 92.1 (65.6–128.0) 65.6 (55.0 to 76.3) 34.4 (26.7–45.9) 40.2 (30.5–57.9) 9.9 (4.3 to 15.5) 55.3 (43.5 to 67.1) < 0.001
 1,25(OH)2D (pmol/l) 81.6 (60.8–100.9) 90.0 (68.3–121.8) 12.3 (3.1 to 21.4) 87.7 (65.2–104.8) 76.1 (60.5–105.1) −7.8 (−15.5 to 0.0) 17.1 (6.2 to 27.9) 0.004
Hematological parameters
 Hemoglobin (g/dL) 14.2 ± 1.6 13.7 ± 1.8 −0.5 (−0.9 to −0.2) 14.2 ± 1.5 13.8 ± 1.9 −0.5 (−0.9 to −0.1) −0.04 (−0.53 to 0.45) 0.87
 Hematocrit (%) 42.2 ± 4.9 41.6 ± 5.7 −0.6 (−1.7 to 0.4) 42.2 ± 4.2 40.9 ± 5.6 −1.3 (−2.5 to −0.1) 0.7 (−0.8 to 2.2) 0.36
 Leukocytes (109/L) 8.1 (6.8–9.6) 8.2 (6.4–9.4) −0.3 (−0.7 to 0.1) 7.7 (6.2–9.6) 7.2 (5.7–9.2) −0.3 (−0.8 to 0.2) 0.2 (−0.4 to 0.7) 0.60
 Erythrocytes (1012/L) 4.7 (4.4–5.0) 4.7 (4.3–5.1) 0.0 (−0.1 to 0.1) 4.6 (4.3–4.9) 4.6 (4.1–5.0) −0.5 (−1.5 to 0.5) 0.15 (−0.04 to 0.33) 0.10
 MCV (μm3) 90.6 (88.1–93.4) 88.7 (84.8–94.0) −1.6 (−3.0 to −0.2) 92.9 (90.1–95.6) 90.6 (87.1–93.1) −1.9 (−3.6 to 0.1) 0.5 (−2.4 to 1.4) 0.33
 MCH (pg Hb/red blood cell) 30.7 ± 2.0 29.4 ± 2.7 −1.3 (−1.7 to 0.8) 31.2 ± 2.5 30.3 ± 2.2 −0.9 (−1.4 to 0.4) 0.6 (−1.3 to 0.0) 0.05
 MCHC (g/L) 33.6 (33.0–34.8) 32.9 (31.9–34.9) −0.8 (−1.2 to −0.4) 33.9 (33.0–34.7) 33.7 (32.8–34.5) −0.0 (−0.4 to 0.4) −0.7 (−1.2 to −0.3) 0.001
 RDW (%) 12.7 (11.9–13.5) 13.8 (12.5–15.0) 1.0 (0.6 to 1.4) 12.5 (11.9–13.2) 13.0 (12.4–14.5) 0.8 (0.4 to 1.2) 0.2 (−0.3 to 0.8) 0.37
Additional parameters
 eGFR (mL/min/1.73 m2) 71.7 ± 22.5 61.9 ± 25.3 −9.7 (−13.7 to 5.8) 75.8 ± 23.4 69.9 ± 26.0 −5.9 (−10.0 to −1.8) −4.7 (−10.2 to 0.8) 0.09
 CRP (mg/dL) 0.24 (0.10–0.69) 0.27 (0.14–0.73) 0.04 (−0.12 to 0.19) 0.21 (0.09–0.40) 0.23 (0.11–0.57) 0.02 (0.0 to 0.03) −0.08 (−0.29 to 0.13) 0.86
 Calcium (mmol/L) 2.39 (2.37 to 2.39) 2.47 (2.46 to 2.48) 0.08 (0.05 to 0.11) 2.38 (2.37 to 2.39) 2.41 (2.40 to 2.42) 0.03 (0.00 to 0.06) 0.05 (0.01 to 0.10) 0.001
  1. 1,25(OH) 2 D 1,25-dihydroxyvitamin D, 25OHD 25-hydroxyvitamin D, CRP C-reactive protein, eGFR estimated globular filtration rate, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, MCV mean corpuscular volume, RDW red blood cell distribution width
  2. aResults are presented as means and 95% confidence interval; bprobability of group differences in mean change differences between groups