Skip to main content

Table 2 Changes in the levels of coenzyme Q10, vitamin E, oxidative stress, antioxidant enzymes activities, and inflammation in HCC patients after supplementation

From: Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial

  Placebo (n = 19) Q10-300 (n = 20)
Week 0 Week 12 Week 12-0b Week 0 Week 12 Week 12-0
 coenzyme Q10 (μM) 0.32 ± 0.14 (0.33)a 0.38 ± 0.09 (0.37) 0.11 ± 0.15 (0.09) 0.27 ± 0.08 (0.27) 1.47 ± 0.82 (1.58)e,d 1.19 ± 0.84 (1.35)d
 vitamin E (μM) 11.84 ± 2.98 (11.66) 12.04 ± 4.13 (11.47) 0.20 ± 2.79 (0.51) 11.16 ± 2.20 (12.10) 11.52 ± 3.28 (10.54) 0.43 ± 2.29 (0.54)
Oxidative stress
 MDA (μM) 1.37 ± 0.34 (1.42) 1.41 ± 0.30 (1.37) 0.08 ± 0.35 (0.11) 1.48 ± 0.58 (1.33) 1.22 ± 0.31 (1.10)e,d −0.27 ± 0.68 (−0.33)d
Antioxidant enzymes activity
 SOD (U/mg protein) 16.94 ± 8.78 (13.10) 17.12 ± 5.79 (16.90) 0.73 ± 11.37 (3.00) 13.93 ± 4.35 (13.16) 21.26 ± 7.86 (22.02)e,d 7.96 ± 7.15 (7.50)d
 CAT (U/mg protein) 16.36 ± 7.97 (12.00) 15.24 ± 6.62 (12.80) −1.71 ± 6.25 (0.29) 14.74 ± 7.63 (11.75) 18.00 ± 6.82 (16.76)e,d 3.28 ± 7.76 (4.80)d
 GPx (U/mg protein) 15.22 ± 5.76 (14.66) 12.73 ± 5.46 (12.20) −1.10 ± 7.26 (−0.60) 15.94 ± 4.77 (17.46) 19.40 ± 8.34 (22.08)e,d 4.08 ± 7.67 (4.70)d
Inflammatory markers
 hs-CRP (mg/L) 3.5 ± 3.6 (1.6) 2.1 ± 3.9 (0.8) −1.5 ± 4.2 (−0.8) 4.2 ± 4.2 (2.8) 2.6 ± 4.2 (1.0)e −1.7 ± 4.8 (−1.3)
 TNF-α (pg/mL) 0.89 ± 0.71 (1.16) 1.77 ± 4.38 (0.73) 0.88 ± 4.59 (−0.10) 0.84 ± 0.78 (0.73) 1.06 ± 1.02 (0.86) 0.30 ± 1.19 (0.02)
 IL-6 (pg/mL) 3.76 ± 2.30 (3.44) 2.83 ± 3.64 (1.34) −1.05 ± 3.72 (−1.65) 3.07 ± 2.03 (1.98) 1.62 ± 0.75 (1.70)e −0.49 ± 2.96 (−0.70)
  1. CAT Catalase activity, GPx glutathione peroxidase, HCC hepatocellular carcinoma, hs-CRP high sensitivity C-reactive protein, IL-6 interleukin-6, MDA Malondialdehyde, SOD superoxide dismutase, TNF-α tumor necrosis factor-α
  2. ameans ± SD (medians)
  3. bDifference between week 12 and week 0
  4. dvalues are significantly different between the two groups
  5. evalues are significantly different within each group