Table 2 Effect of vitamin D supplementation combined (10 μg or 25 μg)a on serum ferritin, hemoglobin, serum iron, Transferrin Saturation, folic acid and vitamin B12
Baselined | After 16 weeks | Change from baseline to 16 weeks | Difference (95 % CI) compared to placebob | P-valuee | |
|---|---|---|---|---|---|
S-25(OHD) (nmol/l) | |||||
Intervention (n = 143) | 28.7 (18.6) | 48.8 (19.6) | 20.1 (21.7) | 21.3 (16.7, 26.0) | <0.0001 |
Placebo (n = 71) | 29.2 (15.6) | 27.5 (13.7) | -1.5 (11.3) | ||
Hemoglobin (g/dL)c | |||||
Intervention (n = 136) | 13.7 (1.5) | 13.5 (1.6) | -0.21 (0.6) | -0.02 (-0.12, 0.09) | NS |
Placebo (n = 69) | 13.5 (1.4) | 13.3 (1.4) | -0.27 (0.7) | ||
Serum ferritin (μg/L) | |||||
Intervention (n = 143) | 68.4 (77.3) | 68.0 (85.5) | -0.3 (35.7) | 1.9 (-3.2, 7.0) | NS |
Placebo (n = 71) | 54.4 (63.2) | 51.0 (57.8) | -3.4 (19.1) | ||
Serum iron (μg/L) | |||||
Intervention (n = 143) | 14.4 (5.8) | 14.1 (6.1) | -0.4 (5.9) | 0.4 (-0.5, 1.3) | NS |
Placebo (n = 71) | 13.0 (5.9) | 13.5 (6.7) | 0.5 (5.9) | ||
Transferrin saturation (%) | |||||
Intervention (n = 143) | 21.3 (9.4) | 20.6 (9.7) | 0.5 (8.5) | 0.7 (-0.6, 2.0) | NS |
Placebo (n = 71) | 18.3 (8.7) | 18.7 (9.5) | -0.7 (8.6) | ||
S-Total iron binding capacity (nmol/L) | |||||
Intervention (n = 143) | 70.3 (11.5) | 70.8 (11.5) | 0.5 (5.5) | -0.08 (-1.0, 0.8) | NS |
Placebo (n = 71) | 73.2 (10.8) | 73.5 (11.1) | 0.4 (6.1) | ||
S-Folic acid (nmol/L) | |||||
Intervention (n = 143) | 15.6 (6.9) | 15.0 (7.2) | -0.5 (5.1) | -0.1 (-1.0, 0.7) | NS |
Placebo (n = 71) | 15.8 (5.7) | 15.7 (6.0) | -0.1 (6.1) | ||
S-Vitamin B12 (pmol/L) | |||||
Intervention (n = 143) | 334.9 (105)) | 323.3 (112.9) | -9.1 (64.9) | -5.4 (-16.1, 5.3) | NS |
Placebo (n = 71) | 339.9 (105) | 337.2 (118.9) | -2.7 (67.7) | ||