Table 5 Results from assessment of precipitation in TPNaq
TPNaq | Drug | Time after mixing h | Light obscuration | Visible particles and/or Tyndall effect (+/−) | Turbidity (FNU) | pH | |||
|---|---|---|---|---|---|---|---|---|---|
Particles | Particles | Particles | Particles | ||||||
≥0.5 μm/ml | ≥5 μm/ml | ≥10 μm/ml | ≥25 μm/ml | ||||||
None | Acyclovir alone | - | 238 ± 58 | 3 ± 1 | 1 ± 0 | 0 ± 0 | - | 0.07 ± 0.00 | 10.03 |
Ampicillin alone | - | 144 ± 50 | 1 ± 1 | 0 ± 0 | 0 ± 0 | c+ | 0.94 ± 0.06 | 8.87 | |
Ondansetron alone | - | n.d. | n.d. | n.d. | n.d. | - | 0.08 ± 0.01 | 4.21 | |
Paracetamol alonea | - | n.d. | n.d. | n.d. | n.d. | c+ | 0.59 ± 0.01 | 5.33 | |
Paracetamol aloneb | - | n.d. | n.d. | n.d. | n.d. | - | 0.08 ± 0.00 | 5.42 | |
Olimel® N5E | Fresh without drug | - | 119 ± 63 | 2 ± 2 | 1 ± 1 | 0 ± 1 | d+ | 0.10 ± 0.03 | 6.30 |
Acyclovir | 0 | 810 ± 190 | 37 ± 17 | 6 ± 3 | 0 ± 0 | ++ | 0.38 ± 0.37 | 7.80 | |
4 | 6763 ± 1148 | 4051 ± 1578 | 2513 ± 1470 | 691 ± 679 | +++ | 138.09 ± 211.14 | 7.63 | ||
Ampicillin | 0 | 485 ± 412 | 4 ± 2 | 1 ± 0 | 0 ± 0 | e+ | 0.43 ± 0.12 | 7.93 | |
4 | 9550 ± 2285 | 1 ± 1 | 0 ± 0 | 0 ± 0 | e+ | 0.49 ± 0.18 | 7.81 | ||
Ondansetron | 0 | 246 ± 102 | 1 ± 1 | 0 ± 0 | 0 ± 0 | - | 0.08 ± 0.02 | 6.22 | |
4 | 287 ± 84 | 2 ± 2 | 0 ± 0 | 0 ± 0 | - | 0.08 ± 0.01 | 6.15 | ||
Paracetamol | 0 | 242 ± 104 | 9 ± 3 | 1 ± 2 | 0 ± 0 | - | 0.10 ± 0.00 | 6.19 | |
4 | 153 ± 75 | 11 ± 6 | 2 ± 1 | 0 ± 0 | - | 0.09 ± 0.01 | 6.17 | ||
Kabiven® | Fresh without drug | - | 16 ± 2 | 0 ± 0 | 0 ± 0 | 0 ± 0 | d+ | 0.13 ± 0.03 | 5.59 |
Acyclovir | 0 | 3271 ± 2421 | 410 ± 361 | 128 ± 98 | 22 ± 16 | ++ | 2.16 ± 1.80 | 7.18 | |
4 | 7520 ± 229 | 6432 ± 211 | 5163 ± 171 | 2540 ± 33 | +++ | 683.50 ± 135.06 | 7.10 | ||
Ampicillin | 0 | 157 ± 101 | 2 ± 1 | 1 ± 1 | 0 ± 0 | e+ | 0.61 ± 0.22 | 7.77 | |
4 | 3851 ± 2300 | 2 ± 1 | 1 ± 1 | 0 ± 0 | e+ | 0.64 ± 0.18 | 7.67 | ||
Ondansetron | 0 | 103 ± 57 | 5 ± 1 | 2 ± 1 | 0 ± 0 | - | 0.11 ± 0.01 | 5.55 | |
4 | 88 ± 2 | 2 ± 2 | 1 ± 2 | 0 ± 0 | - | 0.12 ± 0.02 | 5.55 | ||
Paracetamol | 0 | 128 ± 125 | 1 ± 0 | 0 ± 0 | 0 ± 0 | - | 0.10 ± 0.02 | 5.56 | |
4 | 36 ± 23 | 0 ± 0 | 0 ± 0 | 0 ± 0 | - | 0.10 ± 0.01 | 5.56 | ||
SmofKabiven® | Fresh without drug | - | 171 ± 100 | 5 ± 5 | 3 ± 3 | 1 ± 1 | d+ | 0.11 ± 0.03 | 5.50 |
Acyclovir | 0 | 650 ± 278 | 23 ± 8 | 4 ± 1 | 0 ± 0 | ++ | 0.11 ± 0.02 | 6.48 | |
4 | 7088 ± 456 | 4043 ± 745 | 2177 ± 697 | 290 ± 139 | +++ | 86.83 ± 36.60 | 6.47 | ||
Ampicillin | 0 | 505 ± 185 | 7 ± 6 | 2 ± 2 | 0 ± 0 | e+ | 0.26 ± 0.04 | 7.64 | |
4 | 2531 ± 1196 | 3 ± 2 | 1 ± 1 | 0 ± 0 | e+ | 0.27 ± 0.04 | 7.48 | ||
Ondansetron | 0 | 172 ± 73 | 1 ± 1 | 0 ± 0 | 0 ± 0 | - | 0.09 ± 0.01 | 5.47 | |
4 | 231 ± 110 | 1 ± 0 | 1 ± 0 | 0 ± 0 | - | 0.09 ± 0.01 | 5.49 | ||
Paracetamol | 0 | 325 ± 73 | 2 ± 0 | 1 ± 0 | 0 ± 0 | f+ | 0.32 ± 0.01 | 5.38 | |
4 | 341 ± 182 | 1 ± 0 | 1 ± 0 | 0 ± 0 | f+ | 0.33 ± 0.01 | 5.38 | ||