Bacillus coagulans MTCC 5856 supplementation in the management of diarrhea predominant Irritable Bowel Syndrome: a double blind randomized placebo controlled pilot clinical study

Majeed, Muhammed; Nagabhushanam, Kalyanam; Natarajan, Sankaran; Sivakumar, Arumugam; Ali, Furqan; Pande, Anurag; Majeed, Shaheen; Karri, Suresh Kumar

doi:10.1186/s12937-016-0140-6

Table 3 Biochemistry and haematology values between two treatment groups

From: Bacillus coagulans MTCC 5856 supplementation in the management of diarrhea predominant Irritable Bowel Syndrome: a double blind randomized placebo controlled pilot clinical study

Lab parameter (Units)	Visit	Placebo	Active	Normal range
Alanine aminotransferase (IU L⁻¹)	Baseline	23.5 ± 6.44	22.8 ± 5.64	0 to 41
Alanine aminotransferase (IU L⁻¹)	Final Visit	23.4 ± 4.81	28.4 ± 11.20	0 to 41
Albumin (g dL⁻¹)	Baseline	4.2 ± 0.36	4.2 ± 0.70	3.5 to 5.2
Albumin (g dL⁻¹)	Final Visit	4.4 ± 0.28	4.1 ± 0.45	3.5 to 5.2
Alkaline phosphatase (U L⁻¹)	Baseline	76.6 ± 8.73	86.0 ± 5.98	53 to 128
Alkaline phosphatase (U L⁻¹)	Final Visit	75.9 ± 8.76	82.8 ± 3.44	53 to 128
Aspartate aminotransferase (IU L⁻¹)	Baseline	24.9 ± 5.79	25.1 ± 5.63	0 to 40
Aspartate aminotransferase (IU L⁻¹)	Final Visit	24.9 ± 6.56	27.4 ± 8.47	0 to 40
Blood urea nitrogen (mg dL⁻¹)	Baseline	12.3 ± 3.38	10.7 ± 1.66	5.0 to 24
Blood urea nitrogen (mg dL⁻¹)	Final Visit	11.1 ± 2.69	10.9 ± 1.85	5.0 to 24
Fasting blood sugar (mg dL⁻¹)	Baseline	99.1 ± 2.54	106.2 ± 3.89	70 to 110
Fasting blood sugar (mg dL⁻¹)	Final Visit	104.2 ± 2.99	120.4 ± 9.48	70 to 110
LDL Cholesterol (mg dL⁻¹)	Baseline	105.4 ± 5.08	109.2 ± 5.69	Up to 140
LDL Cholesterol (mg dL⁻¹)	Final Visit	110.1 ± 4.30	91.3 ± 3.92	Up to 140
Potassium (mEq L⁻¹)	Baseline	4.1 ± 0.19	4.1 ± 0.33	3.5 to 5.2
Potassium (mEq L⁻¹)	Final Visit	4.2 ± 0.18	4.1 ± 0.34	3.5 to 5.2
Serum creatinine (mg %)	Baseline	0.9 ± 0.12	0.9 ± 0.13	0.6 to 1.4
Serum creatinine (mg %)	Final Visit	0.9 ± 0.09	0.9 ± 0.15	0.6 to 1.4
Sodium (mEq L⁻¹)	Baseline	139.8 ± 1.76	139.3 ± 3.30	136 to 145
Sodium (mEq L⁻¹)	Final Visit	140.7 ± 2.58	139.6 ± 4.36	136 to 145
Total bilirubin (mg dL⁻¹)	Baseline	1.2 ± 1.54	0.8 ± 0.27	0.1 to 1.2
Total bilirubin (mg dL⁻¹)	Final Visit	0.8 ± 0.23	0.8 ± 0.23	0.1 to 1.2
Total protein (g dL⁻¹)	Baseline	7.1 ± 0.56	7.2 ± 0.34	6.22 to 8.0
Total protein (g dL⁻¹)	Final Visit	7.5 ± 0.31	7.3 ± 0.50	6.22 to 8.0
Erythrocyte Count (*10⁶ cells)	Baseline	4.9 ± 0.78	5.0 ± 0.53	4.0 to 6.5
Erythrocyte Count (*10⁶ cells)	Final Visit	4.5 ± 0.70	4.6 ± 0.61	4.0 to 6.5
Haematocrit (%)	Baseline	40 ± 0.06	40 ± 0.05	40 to 50
Haematocrit (%)	Final Visit	40 ± 0.06	40 ± 0.06	40 to 50
Haemoglobin (gm %)	Baseline	12.8 ± 2.77	12.9 ± 1.87	11 to 16
Haemoglobin (gm %)	Final Visit	13.8 ± 2.31	13.0 ± 2.39	11 to 16
Leukocyte Count (Cells cu. mm⁻¹)	Baseline	6383.3 ± 16.92	6309.4 ± 16.32	4000 to 11,000
Leukocyte Count (Cells cu. mm⁻¹)	Final Visit	7328.6 ± 18.95	6788.2 ± 16.74	4000 to 11,000
Lymphocytes (%)	Baseline	30 ± 0.06	31 ± 0.06	25 to 40
Lymphocytes (%)	Final Visit	30 ± 0.06	30 ± 0.06	25 to 40
Monocytes (%)	Baseline	0.0 ± 0.01	0.0 ± 0.02	0 to 10
Monocytes (%)	Final Visit	0.0 ± 0.01	0.0 ± 0.01	0 to 10
Neutrophils (%)	Baseline	60 ± 0.05	60 ± 0.06	40 to 75
Neutrophils (%)	Final Visit	60 ± 0.06	60 ± 0.07	40 to 75
Basophils (%)	Baseline	0.0 ± 0.00	0.0 ± 0.00	0 to 1
Basophils (%)	Final Visit	0.0 ± 0.00	0.0 ± 0.00	0 to 1
Eosinpophils (%)	Baseline	0.0 ± 0.01	0.0 ± 0.01	0 to 7
Eosinpophils (%)	Final Visit	0.0 ± 0.01	0.0 ± 0.01	0 to 7
Platelet Count (*10⁵ per cu. mm)	Baseline	2.9 ± 0.67	2.7 ± 0.72	1.5 to 4.5
	Final Visit	3.2 ± 0.78	3.0 ± 0.66	1.5 to 4.5

Values expressed as mean ± S.D

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