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Table 7 Change from baseline to day 180 in serum and synovial fluid biomarkers
| Matrix | Parameter reduction | Day | Placebo (n) | GC (n) | UC-II (n) |
|---|---|---|---|---|---|
| Serum | COMP (ng/mL) | 180 | −51.2 ± 31.3 (53) | −56.5 ± 36.0 (56) | −69.6 ± 40.8 (53) |
| CRP (mg/L) | 180 | 15.1 ± 6.33 (26) | 9.09 ± 5.36 (28) | 13.0 ± 4.64 (28) | |
| Synovial | IL-6 (ng/mL) | 180 | −9.54 ± 4.83 (23) | −9.72 ± 5.28 (24) | −11.8 ± 5.37 (21) |
| MMP-3 (μg/mL) | 180 | −2.24 ± 1.26 (25) | −0.93 ± 0.79 (27) | −2.67 ± 1.85 (23) |
