Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study

Table 6 Reduction in mean WOMAC subscores in placebo, GC and UC-II groups over 180 days

Parameter reduction	Day	Placebo (n = 53)	GC (n = 57)	UC-II (n = 54)	p value
					Overall^a	GC vs PBO	UC-II vs PBO^b	UC-II vs GC^c
WOMAC pain	7	3.21 ± 0.58	4.57 ± 0.54	3.88 ± 0.55	-	-	-	-
	30	6.61 ± 1.04	7.89 ± 1.00	9.18 ± 1.01	-	-	-	-
	60	8.17 ± 1.10	10.1 ± 1.07	12.7 ± 1.09	0.0149	-	0.011	-
	90	11.2 ± 1.17	12.7 ± 1.14	16.4 ± 1.16	0.0063	-	0.0059	-
	120	12.9 ± 1.28	15.6 ± 1.22	19.9 ± 1.26	0.0005	-	0.0004	0.040
	150	15.0 ± 1.21	17.5 ± 1.16	21.5 ± 1.20	0.0007	-	0.0006	0.047
	180	17.0 ± 1.25	19.2 ± 1.20	24.0 ± 1.23	0.0003	-	0.0003	0.016
WOMAC stiffness	7	3.47 ± 0.64	4.22 ± 0.61	4.24 ± 0.62	-	-	-	-
	30	6.81 ± 1.10	8.76 ± 1.05	9.28 ± 1.07	-	-	-	-
	60	9.36 ± 1.28	11.5 ± 1.25	13.1 ± 1.27	-	-	-	-
	90	11.3 ± 1.36	13.8 ± 1.32	17.0 ± 1.35	0.0158	-	0.010	-
	120	13.6 ± 1.40	15.0 ± 1.34	20.0 ± 1.39	0.0035	-	0.0039	0.029
	150	15.5 ± 1.32	17.7 ± 1.26	21.3 ± 1.31	0.0079	-	0.0058	-
	180	17.8 ± 1.31	19.4 ± 1.27	23.8 ± 1.30	0.0043	-	0.004	0.044
WOMAC physical function	7	3.17 ± 0.56	4.14 ± 0.53	3.91 ± 0.53	-	-	-	-
	30	6.30 ± 1.00	7.80 ± 0.96	9.26 ± 0.98	-	-	-	-
	60	7.75 ± 1.08	9.50 ± 1.05	11.9 ± 1.07	0.0278	-	0.020	-
	90	10.4 ± 1.17	12.1 ± 1.14	15.1 ± 1.16	0.0182	-	0.0136	-
	120	12.7 ± 1.20	14.5 ± 1.15	17.9 ± 1.19	0.0083	-	0.0064	-
	150	14.8 ± 1.19	16.9 ± 1.14	20.0 ± 1.18	0.0078	-	0.006	-
	180	17.3 ± 1.21	18.8 ± 1.16	22.5 ± 1.20	0.0068	-	0.007	-

Values presented as Mean ± SE
^aOverall p value was obtained by comparing the mean changes among the three groups using ANCOVA
^bSignificant difference between the UC-II and the placebo groups using Tukey-Kramer test
^cSignificant difference between the UC-II and the GC groups using Tukey-Kramer test. ‘-’denotes a non-significant statistical outcome

ISSN: 1475-2891