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Table 10 Summary of analysis of adverse events in all subjects

From: Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study

  Study group
Placebo (n = 58) GC (n = 65) UCII (n = 63)
Severity    
 Mild 7 21 5
 Moderate 2 7 3
 Severe 0 0 0
Relationship to Test Article    
 Not related 8 14 8
 Possible 1 13 0
 Definite 0 1 0
Body System and AEs    
 Gastrointestinal    
  Acidity 2 3 2
  Acute peptic disorder 1 0 1
  Diarrhea 1 1 0
  Epigastric burning 0 1 0
  Febrile Enteritis 0 1 0
  Heart burn 0 1 0
  Vomiting 0 1 0
  Nausea 0 1 0
 Pain    
  Arthralgia 0 1 0
  Body pain 0 1 0
  Low back pain 1 1 0
  Neck Pain 0 1 1
  Headache 2 4 0
  Myalgia 0 1 0
 Dermatology    
  Itching 0 2 0
  Xerotic skin 0 0 1
 Pulmonary/Upper Respiratory    
  Lower respiratory tract infection 0 0 2
  Upper respiratory tract infection 0 1 0
  Cough 0 2 0
 Genitourinary    
  Burning micturition 1 0 0
  Burning sensation 0 0 1
 Cardiovascular    
  Palpitation 0 2 0
 Constitutional Symptoms    
  Fever 1 2 0
  Insomnia 0 1 0
Total Number of Adverse Events Experienced During Study 9 28 8
Total Number of Subjects Experiencing Adverse Events: n (%) 7/58 (12 %) 20/65 (31 %) 8/63 (13 %)