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Table 1 Clinical characteristics of all patients stratified by age

From: Reduced ratio of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid is associated with early onset of acute coronary syndrome

Variables Total 35–50 y 51–74 y ≥75 y P-value
Number of patients 102 11 57 34
 Male, n (%) 73 (71.6 %) 11 (100 %) 46 (80.7 %) 16 (47.1 %) <0.001
 Age (years) 69 (56–77) 42 (38–49) 64 (56–70) 79 (77–84) <0.001
 Body mass index (kg/m2) 24 (22–25) 26 (25–29)*,†† 24 (21–26) 22 (20–24) <0.01
 Triglycerides (mg/dL) 111 (67–171) 143 (132–194) 110 (63–177) 95 (66–129) 0.09
 HDL-C (mg/dL) 45 (39–59) 42 (34–43)* 47 (40–60) 45 (38–60) 0.04
 LDL-C (mg/dL) 114 (92–137) 133 (101–185) 113 (90–132) 117 (84–148) 0.09
 HbA1c (%) 5.9 (5.6–6.4) 5.8 (5.4–6.7) 6.0 (5.5–6.6) 5.9 (5.6–6.4) 0.53
Fatty acid concentrations
 EPA (μg/mL) 43 (29–65) 28 (21–55)*,† 43 (34–65) 46 (30–69) 0.12
 DHA (μg/mL) 119 (97–149) 102 (94–140) 118 (97–150) 125 (97–163) 0.36
 AA (μg/mL) 165 (141–206) 193 (164–234) 167 (152–203) 143 (126–211) 0.09
 EPA/AA 0.25 (0.17–0.37) 0.17 (0.07–0.23)*,† 0.26 (0.18–0.37) 0.29 (0.19–0.42) 0.03
 DHA/AA 0.75 (0.59–0.96) 0.70 (0.47–0.89) 0.67 (0.56–0.95) 0.83 (0.70–1.00) 0.05
Complications
 Dyslipidemia, n (%) 38 (37 %) 6 (55 %) 22 (39 %) 10 (29 %) 0.31
 Hypertension, n (%) 63 (62 %) 5 (45 %) 34 (60 %) 24 (71 %) 0.29
 Diabetes mellitus, n (%) 29 (28 %) 2 (18 %) 19 (33 %) 8 (24 %) 0.44
 Current smoking, n (%) 44 (43 %) 9 (82 %) 28 (49 %) 7 (21 %) <0.01
Drugs
 ACEI/ARB, n (%) 27 (26 %) 1 (9 %) 11 (19 %) 15 (44 %) 0.01
 β-blockers, n (%) 10 (10 %) 1 (9 %) 4 (7 %) 5 (15 %) 0.49
 Calcium channel blockers, n (%) 27 (26 %) 1 (9 %) 15 (26 %) 11 (32 %) 0.31
 Statins, n (%) 15 (15 %) 2 (18 %) 11 (19 %) 2 (6 %) 0.20
 Aspirin, n (%) 16 (16 %) 2 (18 %) 8 (14 %) 6 (18 %) 0.28
  1. Unless indicated otherwise, data are presented as median and quartiles
  2. Abbreviations: AA arachidonic acid, ACEI angiotensin converting enzyme inhibitors, ARB angiotensin II receptor blockers, DHA docosahexaenoic acid, EPA eicosapentaenoic acid, HbA1c glycated hemoglobin, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol
  3. *P <0.05 (vs. age 51–74)
  4. P <0.05 (vs. age ≥75)
  5. ††P <0.01 (vs. age ≥75)