Table 3 Maximum voluntary muscle strength (Newton [N]). Baseline data and percentage change after 12 months of treatment according to group allocation. Median with interquartile range (25–75 % percentiles)
Muscle group | P-value | P-value* | ||
|---|---|---|---|---|
Baseline (Newton) | Change after 12 months (%) | |||
Hand grip | 0.79 | 0.58 | ||
Placebo | 287 (257;311) | −0.18 (−7.02;6.78) | ||
Melatonin | 281 (244;333) | −0.75 (−10.40;7.59) | ||
Elbow extension | 0.23 | 0.74 | ||
Placebo | 116 (98;138) | 6.21 (1.23;12.85) | ||
Melatonin | 111 (92;121) | 5.20 (−3.51;15.28) | ||
Elbow flexion | 0.18 | 0.37 | ||
Placebo | 178 (156;192) | 1.95 (−6.77;10.75) | ||
Melatonin | 165 (152;185) | −1.45 (−9.12;6.91) | ||
Knee extension 90° | 0.67 | 0.99 | ||
Placebo | 309 (278;377) | 0.33 (−2.68;5.44) | ||
Melatonin | 312 (275;357) | 0.55 (−6.66;11.26) | ||
Knee flexion 90° | 0.40 | 0.93 | ||
Placebo | 160 (137;177) | 0.26 (−7.13;16.89) | ||
Melatonin | 153 (121;177) | 0.00 (−6.09;13.79) | ||
Knee extension 60° | 0.26 | 0.33 | ||
Placebo | 384 (326;433) | 0.76 (−4.08;4.16) | ||
Melatonin | 370 (313;410) | 1.73 (−5.94;10.49) | ||
Knee flexion 60° | 0.44 | 0.54 | ||
Placebo | 169 (139;203) | 4.31 (−9.61;22.58) | ||
Melatonin | 163 (138;182) | 0.99 (−2.53;9.66) | ||