From: Salacia reticulata (Kothala himbutu) revisited; a missed opportunity to treat diabetes and obesity?
Shimoda et al. 1998 [19] | Kajimoto et al. 2000 [28] | Jayawardena et al. 2005 [29] | Shivaprasad et al. 2013 [30] | Ofner et al. 2013 [31] | |
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Study design | Single point Sucrose tolerance test | Placebo controlled cross-over trial | Double blind randomized placebo controlled cross-over trial | Double blind randomized placebo controlled trial | Randomized open label study |
Study duration | Single point intervention | 6 weeks | 3 months | 6 weeks | 4 weeks |
Study population | Healthy Adults | Type 2 diabetes patients | Type 2 diabetes patients | Prediabetes (IFG & IGT) | Healthy adults |
Number of participants | 7 | 20 | 51 | 29 | 40 |
Source of SRE | Stem | Stem | Patented product | Leaves Root bark | Root powder (Exadipin) |
Dose of SRE | 200 mg (single dose) | 240 mg/day | Not mentioned | 500 mg/day | 600 mg/day |
Background oral hypoglycaemic therapy | None | None | Metformin Glibemclamide | None | None |
End point(s) | Postprandial glucose value | FBS HbA1C BMI | HbA1C | 1. FBS | |
2. Improvement in LDL-C |