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Table 3 Treatment effect in hemoglobin, ferritin and total iron concentrations of children

From: Efficacy of different strategies to treat anemia in children: a randomized clinical trial

Evaluation IS IFS MMS FW FCF p
Hemoglobin
(g/dL)
     
N 40 42 36 48 51  
Baseline 10.45 (10.18, 10.72) 10.72 (10.49, 10.95) 10.73 (10.52, 10.94) 10.55 (10.32, 10.78) 10.51 (10.22, 10.80) 0.487
Final 11.94 (11.60, 12.27)1 12.24 (11.90, 12.58)1 12.14 (11.80, 12.48)1 11.62 (11.28, 11.96) 11.38 (11.07, 11.68)2 0.001
Change 1.49 (1.13, 1.84)†1 1.52 (1.13, 1.91)†1 1.41 (1.05, 1.76)†1 1.07 (0.77, 1.36)† 0.86 (0.60, 1.13)†2 0.012
Adjusted change * 1.43 (1.05, 1.80) 1.58 (1.26, 1.89)1 1.46 (1.08, 1.83)1 1.25 (0.89, 1.62) 0.94 (0.65, 1.22)2 0.034
Ferritin
(μg/dL)
     
N‡ 29 32 23 38 46  
Baseline 30.04 (9.90, 50.18) 72.18 (41.64, 102.71) 22.83 (2.97, 42.69) 60.93 (36.55, 85.31) 57.95 (31.18, 84.72) 0.073
Final 55.50 (26.79, 84.22) 51.24 (26.83, 75.64) 20.53 (4.12, 36.94) 48.16 (21.33, 74.98) 60.45 (32.26, 88.63) 0.366
Change 25.47 (3.97, 46.96)†1 -20.94 (-44.78, 2.89)2 -2.30 (-10.61, 6.01) -12.77 (-35.49, 9.95)2 2.49 (-17.90, 22.89) 0.042
Adjusted change * 21.43 (-4.05, 46.91) 0.94 (-19.50, 21.38) 0.67 (-24.96, 26.30) -4.06 (-26.80, 18.69) 20.29 (2.97, 37.62) 0.200
Total Iron
(μg/dL)
     
N‡ 26 30 21 33 46  
Baseline 1.05 (0.90, 1.20) 1.01 (0.86, 1.16) 1.04 (0.88, 1.19) 1.17 (0.99, 1.34) 1.04 (0.90, 1.17) 0.822
Final 1.26 (1.08, 1.45) 1.16 (1.03, 1.29) 1.26 (1.02, 1.50) 1.35 (1.17, 1.53) 1.23 (1.09, 1.38) 0.604
Change 0.21 (0.08, 0.35)† 0.15 (0.04, 0.26)† 0.23 (0.04, 0.42)† 0.19 (0.06, 0.31)† 0.20 (0.10, 0.29)† 0.932
Adjusted change * 0.16 (0.00, 0.31) 0.13 (0.01, 0.25) 0.16 (0.00, 0.32) 0.25 (0.11, 0.39) 0.16 (0.05, 0.26) 0.771
  1. Treatment abbreviations: Iron supplement (IS), iron plus folic acid supplement (IFS), multiple micronutrients supplement (MMS), micronutrient fortified complementary food as porridge powder (FCF), or zinc, iron and ascorbic acid fortified water (FW).
  2. Values are means (95% CI).
  3. * Estimated changes adjusted for initial value, consumed iron in the treatment (according to formula and adherence to the treatment) and community.
  4. † Change is significant within treatment at p < 0.05 in paired T-Test
  5. ‡ Excludes children with positive C-Reactive Protein from qualitative analysis
  6. 1,2 Different numbers indicate significant difference in the Least Significant Test at p < 0.05.