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Table 3 Meta-analysis, subgrouping by age group. SMD analysis of the effect of iron supplementation on cognitive domains

From: The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis

Cognitive domain

Age group

Standardised mean difference (95% CI)

Number of participants/studies

Heterogeneity - I2 test

Attention & concentration

Children aged 6-18

0.62 (0.26 to 0.98)*

132/2 (4 arms)**

0%

 

Pre-menopausal women

0.53 (-0.06 to 1.12)

47/1

Not relevant

Intelligence

Children aged 6-18

0.02 (-0.22 to 0.27)

2289/4 (9 arms)**

82%

 

Pre-menopausal women

0.62 (0.15 to 1.10)*

76/2

0%

Memory

Children aged 6-18

0.33 (-0.19 to 0.85)

132/2 (4 arms)**

35%

 

Pre-menopausal women

0.09 (-0.31 to 0.50)

123/3

18%

Psychomotor

Children aged 6-18

0.19 (-0.17 to 0.54)

132/2 (4 arms)**

0%

 

Pre-menopausal women

0.09 (-0.32 to 0.50)

123/3

21%

Scholastic aptitude

Children aged 6-18

0.03 (-0.63 to 0.69)

1799/3 (6 arms)**

96%

 

Pre-menopausal women

0.77 (-0.08 to 1.62)

25/1

Not relevant

  1. * p < 0.05
  2. ** Two studies included 3 sets of participants defined by baseline iron status [15, 24], and two further studies included 2 sets of participants defined by baseline iron status [21, 23], these arms were entered separately into the meta-analysis.