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Table 4 Mean ± SDc of urinalysis values of male and female rats administered PGX® for 90 days

From: The safety of PolyGlycopleX® (PGX®) as shown in a 90-day rodent feeding study

Parameter (units) Control 1.25% 2.5% 5.0%
Males     
   Volume (mL) 3.0 ± 1.5 4.0 ± 1.7 6.3 ± 4.6 6.4 ± 3.3a
   Specific Gravity 1.074 ± 0.02 1.060 ± 0.017 1.054 ± 0.025 1.045 ± 0.018b
   pH 6.2 ± 0.3 6.4 ± 0.3 6.6 ± 0.3b 7.1 ± 0.5b
   Urobilinogen (EU/dL) 0.6 ± 0.4 0.4 ± 0.4 0.4 ± 0.3 0.5 ± 0.4
   Total Protein (mg/dL) 876+683 808 ± 279 745 ± 412 457 ± 346
Females     
   Volume (mL) 2.9 ± 3.3 4.0 ± 2.7 1.0 ± 1.0 6.8 ± 2.9a
   Specific Gravity 1.055 ± 0.026 1.042 ± 0.017 1.070 ± 0.011 1.027 ± 0.008b
   pH 6.0 ± 0.0 6.2 ± 0.4 6.1 ± 0.2 6.9 ± 0.2a
   Urobilinogen (EU/dL) 0.3 ± 0.3 0.3 ± 0.3 0.4 ± 0.4 0.2 ± 0.0
   Total Protein (mg/dL) 258 ± 245 196 ± 374 111 ± 66 61 ± 46a
  1. a P ≤ 0.05 by Dunn's test; b P ≤ 0.05 by Dunnett/Tamhane-Dunnett test; cSD = standard deviation