The safety of PolyGlycopleX® (PGX®) as shown in a 90-day rodent feeding study

Nutrition Journal

Table 4 Mean ± SD^c of urinalysis values of male and female rats administered PGX^® for 90 days

Parameter (units)	Control	1.25%	2.5%	5.0%
Males
Volume (mL)	3.0 ± 1.5	4.0 ± 1.7	6.3 ± 4.6	6.4 ± 3.3^a
Specific Gravity	1.074 ± 0.02	1.060 ± 0.017	1.054 ± 0.025	1.045 ± 0.018^b
pH	6.2 ± 0.3	6.4 ± 0.3	6.6 ± 0.3^b	7.1 ± 0.5^b
Urobilinogen (EU/dL)	0.6 ± 0.4	0.4 ± 0.4	0.4 ± 0.3	0.5 ± 0.4
Total Protein (mg/dL)	876+683	808 ± 279	745 ± 412	457 ± 346
Females
Volume (mL)	2.9 ± 3.3	4.0 ± 2.7	1.0 ± 1.0	6.8 ± 2.9^a
Specific Gravity	1.055 ± 0.026	1.042 ± 0.017	1.070 ± 0.011	1.027 ± 0.008^b
pH	6.0 ± 0.0	6.2 ± 0.4	6.1 ± 0.2	6.9 ± 0.2^a
Urobilinogen (EU/dL)	0.3 ± 0.3	0.3 ± 0.3	0.4 ± 0.4	0.2 ± 0.0
Total Protein (mg/dL)	258 ± 245	196 ± 374	111 ± 66	61 ± 46^a

^a P ≤ 0.05 by Dunn's test; ^b P ≤ 0.05 by Dunnett/Tamhane-Dunnett test; ^cSD = standard deviation

ISSN: 1475-2891