Table 3 Mean clinical biochemistry values of female rats administered PGX® for 90 days
From: The safety of PolyGlycopleX® (PGX®) as shown in a 90-day rodent feeding study
Parameter (units) | Control | 1.25% | 2.5% | 5.0% |
|---|---|---|---|---|
Aspartate Aminotransferase (U/L) | 84 ± 13 | 86 ± 6 | 88 ± 10 | 101 ± 18a |
Alanine Aminotransferase (U/L) | 32 ± 3 | 38 ± 4 | 40 ± 7 | 54 ± 14a |
Sorbitol Dehydrogenase (U/L) | 10.0 ± 2.0 | 9.2 ± 1.7 | 10.3 ± 2.2 | 10.4 ± 2.0 |
Alkaline Phosphatase (U/L) | 87 ± 31 | 97 ± 18 | 89 ± 25 | 103 ± 24 |
Total Bilirubin (mg/dL) | 0.16 ± 0.03 | 0.16 ± 0.02 | 0.16 ± 0.02 | 0.18 ± 0.02 |
Blood Urea Nitrogen (mg/dL) | 18 ± 2 | 17 ± 2 | 19 ± 1 | 18 ± 2 |
Creatinine (mg/dL) | 0.41 ± 0.03 | 0.42 ± 0.04 | 0.44 ± 0.03 | 0.43 ± 0.04 |
Cholesterol (mg/dL) | 98 ± 8 | 106 ± 11 | 102 ± 16 | 111 ± 13 |
Triglycerides (mg/dL) | 25 ± 5 | 31 ± 8 | 29 ± 8 | 34 ± 8a |
Glucose (mg/dL) | 115 ± 8 | 111 ± 7 | 115 ± 10 | 111 ± 7 |
Total Protein (g/dL) | 6.5 ± 0.3 | 6.5 ± 0.2 | 6.5 ± 0.3 | 6.4 ± 0.3 |
Albumin (g/dL) | 3.5 ± 0.2 | 3.5 ± 0.2 | 3.5 ± 0.2 | 3.5 ± 0.2 |
Globulin (g/dL) | 3.0 ± 0.2 | 3.0 ± 0.2 | 3.1 ± 0.2 | 2.9 ± 0.2 |
Calcium (mg/dL) | 10.7 ± 0.4 | 10.6 ± 0.3 | 10.5 ± 0.1 | 10.7 ± 0.4 |
Inorganic Phosphorus (mg/dL) | 5.9 ± 0.5 | 5.5 ± 0.6 | 4.9 ± 0.4b | 5.4 ± 0.7 |
Sodium (mmol/L) | 143.5 ± 5.8 | 141.0 ± 6.9 | 143.4 ± 5.6 | 136.6 ± 5.1b |
Potassium (mmol/L) | 5.02. ± 0.28 | 4.88 ± 0.25 | 4.89 ± 0.25 | 4.71 ± 0.25b |
Chloride (mmol/L) | 104.9 ± 4.0 | 102.3 ± 5.1 | 104.8 ± 3.4 | 100.4 ± 3.b |