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Table 3 Mean clinical biochemistry values of female rats administered PGX® for 90 days

From: The safety of PolyGlycopleX® (PGX®) as shown in a 90-day rodent feeding study

Parameter (units) Control 1.25% 2.5% 5.0%
Aspartate Aminotransferase (U/L) 84 ± 13 86 ± 6 88 ± 10 101 ± 18a
Alanine Aminotransferase (U/L) 32 ± 3 38 ± 4 40 ± 7 54 ± 14a
Sorbitol Dehydrogenase (U/L) 10.0 ± 2.0 9.2 ± 1.7 10.3 ± 2.2 10.4 ± 2.0
Alkaline Phosphatase (U/L) 87 ± 31 97 ± 18 89 ± 25 103 ± 24
Total Bilirubin (mg/dL) 0.16 ± 0.03 0.16 ± 0.02 0.16 ± 0.02 0.18 ± 0.02
Blood Urea Nitrogen (mg/dL) 18 ± 2 17 ± 2 19 ± 1 18 ± 2
Creatinine (mg/dL) 0.41 ± 0.03 0.42 ± 0.04 0.44 ± 0.03 0.43 ± 0.04
Cholesterol (mg/dL) 98 ± 8 106 ± 11 102 ± 16 111 ± 13
Triglycerides (mg/dL) 25 ± 5 31 ± 8 29 ± 8 34 ± 8a
Glucose (mg/dL) 115 ± 8 111 ± 7 115 ± 10 111 ± 7
Total Protein (g/dL) 6.5 ± 0.3 6.5 ± 0.2 6.5 ± 0.3 6.4 ± 0.3
Albumin (g/dL) 3.5 ± 0.2 3.5 ± 0.2 3.5 ± 0.2 3.5 ± 0.2
Globulin (g/dL) 3.0 ± 0.2 3.0 ± 0.2 3.1 ± 0.2 2.9 ± 0.2
Calcium (mg/dL) 10.7 ± 0.4 10.6 ± 0.3 10.5 ± 0.1 10.7 ± 0.4
Inorganic Phosphorus (mg/dL) 5.9 ± 0.5 5.5 ± 0.6 4.9 ± 0.4b 5.4 ± 0.7
Sodium (mmol/L) 143.5 ± 5.8 141.0 ± 6.9 143.4 ± 5.6 136.6 ± 5.1b
Potassium (mmol/L) 5.02. ± 0.28 4.88 ± 0.25 4.89 ± 0.25 4.71 ± 0.25b
Chloride (mmol/L) 104.9 ± 4.0 102.3 ± 5.1 104.8 ± 3.4 100.4 ± 3.b
  1. a Statistically different from control (P ≤ 0.05) by Dunn's test; b Statistically different from control (P≤ 0.05) by Dunnett test