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Table 2 Mean clinical biochemistry values of male rats administered PGX® for 90 days

From: The safety of PolyGlycopleX® (PGX®) as shown in a 90-day rodent feeding study

Parameter (units) Control 1.25% 2.5% 5.0%
Aspartate Aminotransferase (U/L) 107 ± 32 82 ± 7 85 ± 15 92 ± 13
Alanine Aminotransferase (U/L) 50 ± 16 43 ± 7 46 ± 9 48 ± 7
Sorbitol Dehydrogenase (U/L) 8.4 ± 2.7 8.3 ± 3.0 8.2 ± 2.0 8.3 ± 2.0
Alkaline Phosphatase (U/L) 107 ± 30 112 ± 32 96 ± 13 113 ± 25
Total Bilirubin (mg/dL) 0.12 ± 0.01 0.12 ± 0.01 0.12 ± 0.02 0.13 ± 0.02
Blood Urea Nitrogen (mg/dL) 17 ± 2 18 ± 2 16 ± 1 17 ± 2
Creatinine (mg/dL) 0.31 ± 0.04 0.32 ± 0.03 0.32 ± 0.03 0.33 ± 0.03
Cholesterol (mg/dL) 99 ± 19 102 ± 25 100 ± 15 92 ± 11
Triglycerides (mg/dL) 36 ± 11 45 ± 19 44 ± 16 44 ± 10
Glucose (mg/dL) 115 ± 12 113 ± 5 113 ± 8 109 ± 8
Total Protein (g/dL) 6.2 ± 0.2 6.2 ± 0.2 6.2 ± 0.3 6.2 ± 0.2
Albumin (g/dL) 3.1 ± 0.2 3.1 ± 0.1 3.2 ± 0.1 3.3 ± 0.1a
Globulin (g/dL) 3.1 ± 0.2 3.0 ± 0.2 3.0 ± 0.2 2.9 ± 0.2
Calcium (mg/dL) 10.3 ± 0.3 10.3 ± 0.3 10.4 ± 0.3 10.7 ± 0.3
Inorganic Phosphorus (mg/dL) 6.9 ± 0.4 7.0 ± 0.7 7.1 ± 0.6 7.5 ± 1.0
Sodium (mmol/L) 144.2 ± 5.6 145.5 ± 4.8 145.0 ± 4.8 145.6 ± 6.2
Potassium (mmol/L) 5.39 ± 0.28 5.39 ± 0.4 5.44 ± 0.23 5.34 ± 0.46
Chloride (mmol/L) 102.4 ± 4.0 103.4 ± 3.3 102.9 ± 2.9 102.9 ± 4.1
  1. aStatistically different from control (P ≤ 0.05) by Dunn's test