Table 2 Mean clinical biochemistry values of male rats administered PGX® for 90 days
From: The safety of PolyGlycopleX® (PGX®) as shown in a 90-day rodent feeding study
Parameter (units) | Control | 1.25% | 2.5% | 5.0% |
|---|---|---|---|---|
Aspartate Aminotransferase (U/L) | 107 ± 32 | 82 ± 7 | 85 ± 15 | 92 ± 13 |
Alanine Aminotransferase (U/L) | 50 ± 16 | 43 ± 7 | 46 ± 9 | 48 ± 7 |
Sorbitol Dehydrogenase (U/L) | 8.4 ± 2.7 | 8.3 ± 3.0 | 8.2 ± 2.0 | 8.3 ± 2.0 |
Alkaline Phosphatase (U/L) | 107 ± 30 | 112 ± 32 | 96 ± 13 | 113 ± 25 |
Total Bilirubin (mg/dL) | 0.12 ± 0.01 | 0.12 ± 0.01 | 0.12 ± 0.02 | 0.13 ± 0.02 |
Blood Urea Nitrogen (mg/dL) | 17 ± 2 | 18 ± 2 | 16 ± 1 | 17 ± 2 |
Creatinine (mg/dL) | 0.31 ± 0.04 | 0.32 ± 0.03 | 0.32 ± 0.03 | 0.33 ± 0.03 |
Cholesterol (mg/dL) | 99 ± 19 | 102 ± 25 | 100 ± 15 | 92 ± 11 |
Triglycerides (mg/dL) | 36 ± 11 | 45 ± 19 | 44 ± 16 | 44 ± 10 |
Glucose (mg/dL) | 115 ± 12 | 113 ± 5 | 113 ± 8 | 109 ± 8 |
Total Protein (g/dL) | 6.2 ± 0.2 | 6.2 ± 0.2 | 6.2 ± 0.3 | 6.2 ± 0.2 |
Albumin (g/dL) | 3.1 ± 0.2 | 3.1 ± 0.1 | 3.2 ± 0.1 | 3.3 ± 0.1a |
Globulin (g/dL) | 3.1 ± 0.2 | 3.0 ± 0.2 | 3.0 ± 0.2 | 2.9 ± 0.2 |
Calcium (mg/dL) | 10.3 ± 0.3 | 10.3 ± 0.3 | 10.4 ± 0.3 | 10.7 ± 0.3 |
Inorganic Phosphorus (mg/dL) | 6.9 ± 0.4 | 7.0 ± 0.7 | 7.1 ± 0.6 | 7.5 ± 1.0 |
Sodium (mmol/L) | 144.2 ± 5.6 | 145.5 ± 4.8 | 145.0 ± 4.8 | 145.6 ± 6.2 |
Potassium (mmol/L) | 5.39 ± 0.28 | 5.39 ± 0.4 | 5.44 ± 0.23 | 5.34 ± 0.46 |
Chloride (mmol/L) | 102.4 ± 4.0 | 103.4 ± 3.3 | 102.9 ± 2.9 | 102.9 ± 4.1 |