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Table 1 Faecal bifidobacteria and total anaerobe counts (m ± SEM, log cfu/g) in 40 healthy volunteers assigned to a 7-d consumption of short-chain fructo-oligosaccharides (scFOS) at a dose from 2.5 to 10 g/d or a placebo

From: The capacity of short-chain fructo-oligosaccharides to stimulate faecal bifidobacteria: a dose-response relationship study in healthy humans

scFOS dose (g/d) Total anaerobes Bifidobacteria
  d8* d15* Δd15-d8 P** d8* d15* Δ d15-d8 P**
0 (placebo) 12.59 ± 0.17 12.54 ± 0.12 - 0.05 ± 0.16 *** 10.06 ± 0.29 9.57 ± 0.21 - 0.49 ± 0.23 ***
2.5 12.32 ± 0.21 12.55 ± 0.14 + 0.22 ± 0.19 0.29 9.15 ± 0.59 9.39 ± 0.70 + 0.24 ± 0.16 0.02
5.0 12.48 ± 0.18 12.66 ± 0.14 + 0.17 ± 0.28 0.51 10.21 ± 0.21 10.67 ± 0.22 + 0.46 ± 0.31 0.03
7.5 12.45 ± 0.16 12.55 ± 0.13 + 0.09 ± 0.06 0.42 9.28 ± 0.49 9.85 ± 0.35 + 0.57 ± 0.25 0.01
10 11.65 ± 0.37 12.68 ± 0.14 + 1.04 ± 0.41 0.03 9.00 ± 0.81 10.18 ± 0.60 + 1.18 ± 0.42 0.003
  1. *days 1–8 was a run-in period during which no treatment occurred, but subjects excluded from their diet fermented dairy products containing viable bifidobacteria and limited consumption of food products containing high level of non-digestible oligosaccharides.
  2. ** Statistical analyses were performed versus placebo, on the difference d15-d8, using an unpaired t-test
  3. *** As the difference days 15-8 with placebo was the reference, p-values are not reported.