Reference | Condition | n | Protocol | Outcome | Evidence Grade |
---|---|---|---|---|---|
9 | Migraine headaches | 21 | One initial intramuscular injection (IM) followed by a series of 6 or 8 intravenous (IV) treatments (maximum 50 mg), then regular IM injections (25–50 mg) combined with 50–150 mg of oral administration. | 17 of the 21 subjects had a positive response. | C: case-series |
10 | Headaches of different etiologic types | 100 | 100 mg of IV sodium nicotinate or niacin. | 75 of the 100 subjects had complete relief. | C: case-series |
11 | Migraine headaches | 15 | 100 mg of IV niacin, and an additional 50–200 mg if necessary to ensure a flushing response of more than 15-minutes. | 13 of the 15 subjects had a positive response. The headaches were relieved in 27 of the 31 times when niacin was administered by IV administration. | C: case-series |
12 | Tension headaches | 35 | 22 subjects received 100–200 mg of IV niacin for a total of 53 times. | 13 of the 22 subjects had a positive response. The headaches were relieved in 41 of the 53 times when niacin was administered by IV administration. | C: case-series |
14 | Emotional or tension headaches | 5 | 100 mg of IV niacin regularly for 12 weeks combined with a graded schedule of oral dosing, beginning at 300 mg daily, increasing to 900 mg daily, and tapering down to 300 mg daily. | All 5 cases of emotional or tension headaches were very responsive to both IV and oral niacin. | C: case-series |
15 | Tension headaches accompanied with depression | 50 | 100 mg of IV niacin regularly for 23 weeks and then continued once every 2 months and as needed. This was combined with a graded schedule of oral dosing, beginning at 300 mg daily, increasing to 900 mg daily, and tapering down to 300 mg daily. | In 44 of the 50 subjects the results with niacin therapy were very satisfactory or favorable. | C: case-series |
18 | Migraine headaches | 1 | 300–500 mg of niacin were chewed and allowed to slightly dissolve in the mouth. | Resolution of migraine headaches. | C: case-report |
6 | Migraine Headaches | 2 | 500 mg of oral niacin taken at the onset of acute symptoms. | In 2 of the 2 subjects, niacin aborted the acute migraine symptoms. In the first subject, niacin resolved the acute attacks in 4 of 4 occasions. In the other subject, niacin resolved the attack on one occasion. | C: case-report |
7 | Migraine headaches | 1 | 375 mg of oral sustained-release niacin twice daily for 1 month, and 375 mg once daily for 2 months. | Migraine-free for the first month, and a marked reduction in migraine headaches over the next 2 months. | C: Case-report |