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Table 2 levels of liver parameters at baseline after Robusta oil treatment and during follow-up

From: Coffee bean extracts rich and poor in kahweol both give rise to elevation of liver enzymes in healthy volunteers

Parameter Normal limits Baseline Treatment Follow-up1 Follow-up 2
   n = 15 n = 15 n = 14 n = 14
Alanine aminotransferase < 45 IU/l 0.38 [0.36,0.56] 0.67 [0.58,1.27]** 0.49 [0.39,0.72]* 0.39 [0.35,0.53]
Aspartate aminotransferase < 50 IU/l 0.32 [0.26,0.38] 0.44 [0.26,0.56] 0.32 [0.28,0.42] 0.38 [0.28,0.41]
Alkaline phosphatase 40 – 125 U/l 0.45 [0.36,0.58] 0.43 [0.35,0.54] 0.42 [0.34,0.51]* 0.49 [0.37,0.53]
Amylase 35 – 130 U/l 0.50 [0.45,0.61] 0.48 [0.38,0.52] 0.49 [0.46,0.58] 0.47 [0.42,0.57]
Bilirubin < 17 umol/l 0.47 [0.41,0.65] 0.53 [0.35,0.65] 0.65 [0.57,0.82]** 0.53 [0.40,0.74]
γ-glutamyltranspeptidase < 40 U/l for women
< 75 U/l for men
0.29 [0.24,0.38] 0.25 [0.20,0.45] 0.31 [0.27,0.51] 0.34 [0.25,0.46]
Lactate dehydrogenase 230 – 485 IU/l 0.60 [0.56,0.61] 0.61 [0.49,0.65] 0.60 [0.50,0.64] 0.54 [0.52,0.65]
  1. All values are medians in units of times the upper limit of normal with the 25th and 75th percentile between brackets. Treatment values were obtained after 16 days of Robusta oil treatment. Follow-up 1 took place four weeks after termination of the intervention and Follow-up2 eight weeks after termination. * value differs significantly from baseline (p < 0.05) in the Wilcoxon signed-rank test. ** p < 0.01