Table 2 Primary and follow-up outcome measures – unadjusted quartiles (n = 2,182)

103.5 ± 11.1

106.0 ± 9.9

104.3 ± 10.7

102.3 ± 11.6

101.2 ± 11.3

<0.001

101.1 ± 12.4

103.9 ± 11.3

102.4 ± 12.3

99.4 ± 12.7

98.5 ± 12.7

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

48.7 ± 8.9

51.3 ± 7.9

49.4 ± 8.7

47.7 ± 9.3

46.5 ± 9.11

<0.001

46.4 ± 9.7

49.0 ± 8.8

47.4 ± 9.7

45.0 ± 9.7

44.0 ± 10.0

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

54.8 ± 7.5

54.8

54.9

54.6

54.7

0.90

54.7 ± 8.1

54.9 ± 7.5

55.0 ± 7.5

54.4 ± 8.6

54.5 ± 8.9

0.63

0.21

0.71

0.89

0.43

0.23

136.4 ± 67.2

146.9 ± 68.3

139.4 ± 68.2

130.7 ± 67.0

128.8 ± 63.8

<0.001

123.7 ± 64.7

133.1 ± 64.2

125.3 ± 63.5

126.8 ± 68.2

108.4 ± 58.7

<0.001

<0.001

<.001

<0.001

0.01

<0.001

55.3 ± 6.3

56.2 ± 6.3

54.9 ± 6.1

55.0 ± 6.4

54.9 ± 6.3

0.004

80.9 ± 15.3

83.6 ± 15.0

82.3 ± 15.2

79.4 ± 15.2

78.3 ± 15.2

<0.001

172 (10.6)

31 (7.3)

36 (8.9)

42 (10.4)

63 (16.6)

<0.001

1.29 ± 0.21

1.34 ± 0.22

1.32 ± 0.22

1.27 ± 0.20

1.23 ± 0.20

<0.001

1.24 ± 0.21

1.30 ± 0.21

1.25 ± 0.22

1.23 ± 0.19

1.16 ± 0.21

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001