Effect of fenugreek (Trigonella foenum-graecumL.) intake on glycemia: a meta-analysis of clinical trials

Nutrition Journal

Table 1 Characteristics of the 10 trials (11 data points) included in the meta-analysis of the effects of fenugreek seeds on glycemia

Lead author, year and country	Population, medication	Design	Age, y	Male (%)	Sample size, N	Duration, days	Fenugreek, preparation	Daily dose, g	Control	Outcomes	Study quality
Lead author, year and country	Population, medication	Design	Age, y	Male (%)	Sample size, N	Duration, days	Fenugreek, preparation	Daily dose, g	Control	Outcomes	RCT	Blinding	Dropout
Bordia et al., 1997 [42], India	Mild T2DM, NR	PL	NR	NR	40	30	Capsule, PS	5	Placebo	FBG, 2 hr glucose	NR	NR	NR
Bordia et al., 1997 [42], India	Severe T2DM, NR	PL	NR	NR	40	30	Capsule, PS	5	Placebo	FBG, 2 hr glucose	NR	NR	NR
Chevassus et al., 2010 [43], France	Overweight, NR	PL	38.0	100	40	42	Capsule, H	1.176	Placebo	FBG, FSI	Yes	DB	5%
Gupta et al., 2001 [23], India	T2DM, SU, BI	PL	51.0	76	25	56	Capsule, H	1	Placebo	FBG, 2 hr glucose, HbA1c, FSI	Yes	DB	4%
Lu et al., 2008 [9], China	T2DM, SU	PL	54.4	55	69	84	Capsule, PS	6.3	Placebo	FBG, 2 hr glucose, HbA1c	Yes	DB	NR
Alamdari et al., 2009 [17], Iran	T2DM, Diet, OAD	CO	43.1	100	12	56	PS	8	Unspecified	FBG, 2 hr glucose, HbA1c	Yes	NR	25%
Chevassus et al., 2009 [25], France	Healthy, NR	CO	22.0	100	12	14	Capsule, H	1.176	Placebo	FBG, FSI	Yes	DB	0%
Raghuram et al., 1994 [7], India	T2DM, BI	CO	46.6	NR	10	15	Chapati^a, PS	25	Chapati	FBG, 1 hr glucose, HbA1c	Yes	NR	NR
Sharma et al., 1990 [44], India	T1DM, Insulin therapy	CO	22.7	70	10	10	Chapati^a, DPS	100	Chapati	FBG, 2 hr glucose, FSI	Yes	NR	NR
Sharma et al., 1990 [22], India	T2DM, BI/metformin	CO	46.0	67	15	10	Chapati^a, DPS	100	Chapati	FBG, 2 hr glucose, FSI	Yes	NR	NR
Sharma et al., 1990 [22], India	T2DM, NR	CO	42.0	NR	5	20	Chapati^a, DPS	100	Chapati	FBG, 2 hr glucose	Yes	NR	NR

Abbreviations: NR not reported, T1DM type 1 diabetes mellitus, T2DM type 2 diabetes mellitus, SU sulfonylurea, BI biguanides, OAD oral antidiabetic drug, PL parallel, CO crossover trials, Daily dose, g fenugreek total daily dose in grams, PS powdered fenugreek seeds, H Hydro-alcoholic extract of fenugreek seeds, DPS Debitterized fenugreek seed powder, FBG fasting blood glucose, HbA1c % glycosylated hemoglobin, FSI fasting serum insulin, RCT randomized control trial, DB double blinded, ^aFenugreek incorporated into chapati (unleavened bread).

ISSN: 1475-2891