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Table 3 Relationship between changes in plasma apolipoprotein A-V levels and metabolic parameters

From: Effects of a 3-year dietary intervention on age-related changes in triglyceride and apolipoprotein A-V levels in patients with impaired fasting glucose or new-onset type 2 diabetes as a function of the APOA5 -1131 T > C polymorphism

 

Changed apo A-V levels

All subjects

TT allele

C allele (TC and CC)

r 1

p 1

r 2

p 2

r 3

p 3

r 1

p 1

r 2

p 2

r 3

p 3

r 1

p 1

r 2

p 2

r 3

p 3

Baseline levels

                  

  Triglyceride

−0.018

0.809

-

-

-

-

−0.082

0.456

-

-

-

-

0.052

0.608

-

-

-

-

  Apo A-V

−0.543

<0.001

−0.555

<0.001

-

-

−0.535

<0.001

−0.552

<0.001

-

-

−0.613

<0.001

−0.617

<0.001

-

-

  Free fatty acids

−0.159

0.030

−0.158

0.031

−0.047

0.529

−0.086

0.439

−0.066

0.554

−0.050

0.656

−0.237

0.017

−0.233

0.020

−0.036

0.722

  HDL cholesterol

−0.203

0.005

−0.221

0.002

−0.105

0.153

−0.156

0.156

−0.173

0.118

−0.111

0.323

−0.263

0.008

−0.266

0.008

−0.107

0.295

Changed levels

                  

  Free fatty acids

0.275

<0.001

0.275

<0.001

0.247

0.001

0.231

0.035

0.226

0.040

0.292

0.008

0.304

0.002

0.301

0.002

0.190

0.060

  Triglycerides

0.022

0.767

0.019

0.800

−0.084

0.257

−0.166

0.131

−0.195

0.077

−0.299

0.006

0.207

0.038

0.221

0.028

0.151

0.138

  HDL cholesterol

0.366

<0.001

0.365

<0.001

0.354

<0.001

0.411

<0.001

0.405

<0.001

0.412

<0.001

0.313

0.002

0.310

0.002

0.266

0.008

  1. Log-transformed.
  2. Tested by Partial correlation analysis.
  3. r 1 : correlation coefficient after adjusting for age, sex, and changes in body weight.
  4. r 2 : correlation coefficient after adjusting for age, sex, changes in body weight and initial triglyceride levels.
  5. r 3 : correlation coefficient after adjusting for age, sex, changes in body weight, initial triglyceride levels, and initial apo A-V levels.