Reducing occupational stress with a B-vitamin focussed intervention: a randomized clinical trial: study protocol

Nutrition Journal

Table 2 Summary of the secondary outcomes implemented in Executive B across all time points

	Visit 1 (baseline)	Visit 2 (6 months)
Screening	Medical history (ie demographic screen, medication use)	Medical history (ie medication use)
Biochemical	MBA & CRP	MBA & CRP
	Homocysteine	Homocysteine
	B Vitamins (B6, B12)	B Vitamins (B6, B12)
	Folate	Folate
	COMT	COMT
	SLC6A4	SLC6A4
	FKBP5	FKBP5
	NPY	NPY
	ADCYAP1R1	ADCYAP1R1
	MTHFR	MTHFR
	CPS1	CPS1
	CBS and DPEP1	CBS and DPEP1
Health	FFQ	FFQ
	BDI-II	BDI-II
	POMS	POMS
	GHQ	GHQ
	PSS	PSS
Cardiovascular	Brachial BP	Brachial BP
	Aortic BP	Aortic BP
	Carotid-femoral PWV	Carotid-femoral PWV
Neuroimaging	Structural MRI	Structural MRI
	Default mode network activation	Default mode network activation
	Metabolite scan (MRS)	Metabolite scan (MRS)
	N-Back working memory (functional MRI)	N-Back working memory (functional MRI)
Other	NEO PI-R	Estimate of compliance
Other	WASI

COMT = Catechol-O-methyltransferase gene, SLC6A4 = Serotonin-transporter gene-linked polymorphic region, FKBP5 = Glucocorticoid receptor-regulating co-chaperone of stress proteins, NPY = Neuropeptide Y, ADCYAP1R1 = Pituitary adenylate cyclase-activating polypeptide receptor, MTHFR = Methylenetetrahydrofolate reductase, CPSI = Carbamoyl phosphate synthetase 1, CBS and DPEP1 = Cystathionine –β-synthase and Dipeptidase 1, FFQ = Food Frequency Questionnaire, BDI-II = Beck Depression Inventory II, POMS = Profile of Mood States, GHQ = General Health Questionnaire, PSS = Perceived Stress Scale, NEO PI-R = NEO-Personality Inventory Revised, WASI = Wechsler Abbreviated Scale of Intelligence.

ISSN: 1475-2891